vitamin k2 mk4 levels elevated in covid patients, k2 mk7 and k1 depleted
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https://pmc.ncbi.nlm.nih.gov/articles/PMC9312339/
without sounding like im coping, is it because k2 mk7 and k1 are being rapidly converted into k2 mk4 which is then detected at high levels in blood?
also is k2 mk4 reactive like k3 is? because it can react with vitamin e? is k2 mk4 as we take in supplement form in oxidized state?
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@sneedful said in vitamin k2 mk4 levels elevated in covid patients, k2 mk7 and k1 depleted:
is it because k2 mk7 and k1 are being rapidly converted into k2 mk4 which is then detected at high levels in blood?
No, I don't think so. K2 MK7 is preferably used for clotting problems. More soluble and also "reactive". Reactive to ox-agression.
But mind the peremption of K2 MK7: very fragile (3 months) if not well encapsulated and protected by e.g. rosmarinus.Source: Chris Masterjohn
There is reason to think MK-7 would be better at supporting blood clotting.
“MK-7 is not just three times better than K1 at reaching bone; it’s also five times better at supporting blood clotting (Schurgers, 2007). This may be because the greater fat-solubility of MK-7 makes it hold on more tightly to the membranes within liver cells, making it stay active in the liver much longer rather than being released and broken down (Shearer, 2008). The liver is where clotting proteins are made, so more extended activity in the liver would explain why MK-7 could better support blood clotting. If this is correct, other long-chain MKs such as MK-8 and MK-9 probably share this property as well.”
https://chrismasterjohnphd.com/blog/2016/12/09/the-ultimate-vitamin-k2-resource/It's advised not to take vitamin E at the same time as vitamin K when taking high dose.
Since I take 1 mg (1 000) K2 MK4 at breakfast, I never take vit E at the same time. 2x/wk for 400 UI mix toco.
