Aldosterone inhibits UCP-1, induces insulin resistance in adipocytes

[Mauritio]

I think the's study shows clearly how bad aldosterone is for our metabolism. Now this was only in adipocytes, but I don't see why this wouldn't be the case in other cells or the rest of the body.

Aldosterone inhibited UCP-1 and increased leptin by 5000%! Now leptin and insulin usually go hand in hand. So if the cells need such a large amount of leptin / insulin, they are probaby very leptin/ insulin in-sensitive a.k.a. resistant.
I personally start my day with a pinch of salt, which lowers aldosterone and should thus increase UCP1 and glucose oxidation.

"Aldosterone is a mineralocorticoid hormone that regulates blood pressure and salt/water balance. Increased aldosterone levels are found in states of disturbed energy balance such as the metabolic syndrome. Adipose tissue has been recognized to play a pivotal role in the regulation of energy homeostasis. We investigated direct aldosterone effects on brown adipocyte function. Aldosterone dose-dependently inhibited expression of uncoupling protein-1 (UCP-1) by 30% (p < 0.01). Furthermore, aldosterone dose-dependently impaired insulin-induced glucose uptake by about 25% (p < 0.01). On a transcriptional level, mRNA of the proinflammatory adipokines leptin and monocyte chemoattractant protein-1 (MCP-1) was increased by 5,000% and 40%, respectively, by aldosterone exposure (p < 0.05). This study demonstrates that aldosterone directly impacts on major adipose functions including stimulation of proinflammatory adipokines."

https://pubmed.ncbi.nlm.nih.gov/16034720/