Separation in Pansterone bottle
-
@engineer It doesn't dissolve in MCT alone. You need pure tocopherol
-
fwiw and maybe this will help you, but I can tell you that micronized DHEA dissolves just fine and stays in solution in straight EVOO at 5mg/ml. micronized progesterone ive dissolved at 30mg/ml in a mix of tocopherols and EVOO. The tocopherols and EVOO is a NOW product
(specifically that one, NOW has various sizes and mixes in different or similar bottle sizes that are all different so you have to carefully read the labels to see what you're getting). For the progesterone, 50mg/ml in the above actually precipitated out even at room temp.I haven't tried pregnenolone but chatgpt says 15-30mg/ml in straight olive oil so I would just do 10mg/ml.
And lastly, I am not a solution mixing expert, but apparently dissolving multiple substances in the same solvent can actually get more in there without a linear effect on max solubility. So i.e. a 5mg/ml DHEA in olive oil solution can still take some progesterone without reaching max solubility capacity for either. l
-
@sunsunsun said in Separation in Pansterone bottle:
fwiw and maybe this will help you, but I can tell you that micronized DHEA dissolves just fine and stays in solution in straight EVOO at 5mg/ml. micronized progesterone ive dissolved at 30mg/ml in a mix of tocopherols and EVOO. The tocopherols and EVOO is a NOW product
(specifically that one, NOW has various sizes and mixes in different or similar bottle sizes that are all different so you have to carefully read the labels to see what you're getting). For the progesterone, 50mg/ml in the above actually precipitated out even at room temp.I haven't tried pregnenolone but chatgpt says 15-30mg/ml in straight olive oil so I would just do 10mg/ml.
And lastly, I am not a solution mixing expert, but apparently dissolving multiple substances in the same solvent can actually get more in there without a linear effect on max solubility. So i.e. a 5mg/ml DHEA in olive oil solution can still take some progesterone without reaching max solubility capacity for either. l
I will try this, but also of note is how my new 6 keto p4 MCT/tocopherol bottles are also filled with crystals. 10s in the microwave and lots of shaking later and they are still not dissolved. Is it possible that there are just always crystals because this is seriously annoying. If even MCT/tocopherol can't do it, maybe EVOO/tocopherol can't either.
-
@engineer apparently 6 keto p4 is quite oil soluble and the range to try is 20-35mg/ml, so I would just do 15mg/ml. if you get a magnetic stirrer and a beaker just dump your idelabs bottle in there, and then dilute it with however much olive oil, and drop in the stirring capsule and set it on low and keep it away from too much natural light and let it run for a few hours. a little heat can speed it up a lot but it isn't really necessary.
apparently keeping dust out of it is important to prevent the solution crashing out into crystals like you're describing, so put a piece of paper on top of the open beaker as it runs and then store with a lid in whatever bottle you use.
if you buy a magnetic stirrer with a heat function be aware that the Chinese one I got has an insane heating function where even the lowest of the low setting is burning hot so maybe look for one with better temp controls. i can't imagine how hot mine would get if I put it on maximum heat.
-
@sunsunsun said in Separation in Pansterone bottle:
Accurate concentrations -
Is the reason why the Idealabs version isn't dissolving because the concentration is too high? The Pansterone is now fully crystal free and that's 2mg/drop so something is clearly different with 6 keto
-
@engineer it's probably because the solution is near the solubility limit before the cold exposure caused it to crystallize, and now without heat and stirring it won't really go back into solution easily. that's why if you are making your own solutions it's better to err on the side of caution and use the lower end of the solubility estimates. haidut probably makes those products at near max solubility.
idealabs lists 6 keto p4 at 1mg a drop, iirc 14-20 drops of an average viscosity liquid is 1ml, so lets just say it's 15mg/ml. Which could be at the lower end of the range of the estimated solubility. I could be totally off though. im doing a lot of guessing.
just to put it in perspective, it takes like an hour minimum of constant stirring at like 25-30c for micronized progesterone to be fully dissolved in the olive oil/vitamin e mix at the 30mg/ml concentration/. so you shaking or a few minutes after warming might not be enough.
-
@engineer btw just found this https://www.ergo-log.com/6-keto-progesterone.html
-
@sunsunsun oh my, if what you're saying is true, then Georgi made a major oversight with how common precipitation seems to be judging by other reports on RPF.
Seems like it might be possible to make some kind of bottle roller or shaker to do all the mixing without having to pour everything into a beaker, I found one by Thermo but it's other-peoples-money priced https://www.thermofisher.com/order/catalog/product/88881003
Cheaper Chinese one https://www.aliexpress.us/item/3256809328945668.html
Turns out it's cheapest on Bezos Mart https://www.amazon.com/Digital-Adjustable-20-80RPM-1min-23h59min-Continuous/dp/B0CFLHMZ6H
Absolutely ridiculous how you need all this extra gear to get what you originally paid for
-
@sunsunsun said in Separation in Pansterone bottle:
@engineer btw just found this https://www.ergo-log.com/6-keto-progesterone.html
Saw that, really interesting how 6 keto has had approximately 0 interest since that 50s study
-
@engineer said in Separation in Pansterone bottle:
Saw that, really interesting how 6 keto has had approximately 0 interest since that 50s study
oh my, if what you're saying is true, then Georgi made a major oversight with how common precipitation seems to be judging by other reports on RPF.
You are coming close to taking the Peat black pill. We welcome you
