ADHD, Severe fatigue, digestion problems etc..

@mostlylurking

That makes sense. Last time I felt good I had been taking 1 gram doses of thiamine every once in a while with b3 and methylene blue.

Might be worth trying that again along with magnesium. I may well need it until I chelate my heavy metals.

@questforhealth said in ADHD, Severe fatigue, digestion problems etc..:

I just took some down the hatch. Lost my scoop so I just put some on the top of a teaspoon.

I HEAVILY suspect heavy metal problems. So probably should be doing thiamine.

I'd like to add that Dr. Costantini advised to take your last dose for the day by 3:00pm. He said that if you take it late in the day that it can disturb your sleep. I think that the reason is that thiamine facilitates the burning of sugar for energy so it will make your blood sugar go down; if your blood sugar gets too low when you're sleeping, it will increase your adrenaline which will wake you up. If that happens and you want to go back to sleep, drink some orange juice with a pinch of salt or drink a glass of milk with a little sugar added (maybe 1 tablespoon to 10-12oz of milk).

Razvan

@questforhealth
Taurine should help for the digestion and also help utilize iron and copper better.
Be carefull with too much B1, it's very good indeed, but can raise acetylcholine too much to the point of making your racing thoughts much worse. Keep in mind what you feel and be aware of your experience even tho it's crazy hard to focus when having low iron and/or low copper.

@Razvan

I might try taurine. Yes the focus is insanely bad. It’s awful. Hopeful iron and thiamine will slowly improve this stuff.

My skin is so pale and sticky recently. What on earth.

@questforhealth said in ADHD, Severe fatigue, digestion problems etc..:

@mostlylurking

That makes sense. Last time I felt good I had been taking 1 gram doses of thiamine every once in a while with b3 and methylene blue.

Might be worth trying that again along with magnesium. I may well need it until I chelate my heavy metals.

The magnesium is a very good idea; I use magnesium glycinate. I get my thiamine hcl from purebulk.com too.

Methylene blue is really an iffy thing to use (in my opinion). If you are thiamine deficient, you can't clear serotonin out of your brain. The effect is like taking an SSRI. Methylene blue acts as an MAO inhibitor and should not be taken if you are taking SSRIs.

Serotonin Syndrome and Thiamine: Is There a Connection?

@mostlylurking

Oh I’ve had weird serotonin stuff before.

If I eat the wrong thing I feel like i’m on an ssri. Serotonin overload.

Razvan

@questforhealth Keep focusing on what we spoke in the other thread and I guarantee you will see improvements. After the focus on iron, its better to focus on copper. There is a trend when raising iron, copper can get even lower and then a period with higher copper foods will be needed.

Razvan

@Razvan Also having good thyroid function and good hormones will store less iron and preferably use it (that's what you need).

@Razvan

On a test my thyroid is good. But I do crave thyroid supplements. However I need to top up my vitamins first I imagine.

Razvan

@questforhealth
What kind of iron supplement are you taking? How much? And how do you feel from it even tho its early to tell?

@Razvan

Floradix.. some german brand with some herbs and berry juice and b vitamins. Not the best but better than having crappy filler. 15mg iron a day.

I do feel a bit better and maybe walking slightly more straight. Slow to tell yet.

@Razvan said in ADHD, Severe fatigue, digestion problems etc..:

@questforhealth
Taurine should help for the digestion and also help utilize iron and copper better.
Be carefull with too much B1, it's very good indeed, but can raise acetylcholine too much to the point of making your racing thoughts much worse. Keep in mind what you feel and be aware of your experience even tho it's crazy hard to focus when having low iron and/or low copper.

Actually, thiamine (B1) modulates acetycholine (I think) so the body is less likely to get overloaded with acetylcholine if your thiamine is adequate for your needs. The action of thiamine is extremely broad and complex. The following article is really above my pay grade; I'll slog through it another day, when I'm not as tired.

Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis
"Our interdisciplinary study shows that thiamin is not only a coenzyme for acetyl-CoA production, but also an allosteric regulator of acetyl-CoA metabolism including regulatory acetylation of proteins and acetylcholine biosynthesis. "

This seems awesome. If I keep taking iron and thiamine and my digestion kicks back in and I can start eating high quality meat and organs... Lots of good stuff can happen surely.

@questforhealth said in ADHD, Severe fatigue, digestion problems etc..:

@Razvan

Floradix.. some german brand with some herbs and berry juice and b vitamins. Not the best but better than having crappy filler. 15mg iron a day.

I do feel a bit better and maybe walking slightly more straight. Slow to tell yet.

I want to voice a word of caution about supplementing with iron. If you are deficient in thiamine, your blood brain barrier can become compromised and the iron can get through it and into your brain and damage it.

@mostlylurking

Aha! So stick to thiamine and magnesium for a start.

I know thiamine can chelate excess iron out of the brain though. so no worries

Razvan

@mostlylurking
The study clearly mentions thiamine also increasing acetylcholine synthesis, but of course thiamine is extremly helpfull and there is even some studies showing that in low dosages increases acetylcholine while in high dosages lowers it due to restoration of the receptor.
I was just making the OP aware of the symptoms.
Thiamine could help ATP and improve hypoxic tendencies when anemic with low oxygenation. Helped with that for me in a similar situation.

@Razvan

Do you feel good eating pork from healthy animals? I am considering trying for the thiamine..

Razvan

@questforhealth
Thiamine can chelate iron, but will not make you more anemic, it's not so strong in doing that as with aspirin and or vitamin E.

Razvan

@Razvan Btw, it's very hard, almost impossible to have high acetylcholine when being anemic and or iron deficient. You are just stuck in a adrenalized, sympathetic and most likely you lack normal vagus nerve function and parasympathetic function which should allow you to relax, that's where acetylcholine could help, most likely you will benefit from stuff like thiamine increasing or regulating acetylcholine.
I did.

@questforhealth said in ADHD, Severe fatigue, digestion problems etc..:

@mostlylurking

Aha! So stick to thiamine and magnesium for a start.

I know thiamine can chelate excess iron out of the brain though. so no worries

It would be a safer plan to just do the thiamine, magnesium glycinate, riboflavin, and niacinamide. I provided the doses that I take earlier. That said, Dr. Costantini preferred for his patients to stop all other supplements for a few weeks in the beginning of taking the high dose thiamine so that he could confirm to his satisfaction that the improvements he saw were indeed due to the thiamine. So I take this to mean that it really isn't necessary to slam yourself with all this stuff all together in the beginning. That said, I didn't stop taking my other supplements when I started taking high dose thiamine. You get to decide; it's your body. Just don't overwhelm yourself with a bunch of new stuff at once or you will have more difficulty discerning which one is doing what.