Protein and the Randle cycle
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I'm wondering how protein oxidation fits in with the Randle cycle. Haidut has pointed out in some interviews that oxidizing amino acids for fuel produces inflammation by generating too much ammonia, potentially a reason high-protein diets haven't worked well for some. Also Broda Barnes noted that excessive protein consumption had a thyroid-suppressive effect (something I've noticed myself). I'm also wondering if oxidizing protein could interfere with fat and carb oxidation in a similar way to the Randle cycle, and if this could help explain the apparent anti-thyroid effect of high protein diets.
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@herayclitus check out Brad Marshall’s YouTube channel (fireinabottle). He shows how not even only tryptophan/methionine/cysteine slow metabolism as Ray said, but that BCAAs actually increase fat oxidation! Which can be a disaster in excess!!
