The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia

yerrag

@mostlylurking

I've been doing s lot of thinking, and while I have gone into megadose thiamine therapy, I'm still in search for an alternative explanation for my current state of ataxia.

Serendipity stepped in lately, and I find myself going into my 4th week of being bedridden because my cat bit my ankle hard leaving me with a wound that won't heal. To make a long story short, a doctor I consulted (belatedly) told me wounds near bones (in my case the ankle bone) are more difficult to heal and he taught me the way to heal such wounds.

So anyway, I had spent a lot of time lying down all this time because it is painful to walk. While I won't know for sure, it seems all this lying down has made it easier for blood to flow to my brain, and I don't seem to have ataxia anymore.

It may be too good to be true, but maybe, just maybe, a little help from gravity may be all it takes.

Until my wound heals and I can go back to freely walking, there is no telling for sure.

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking

I've been doing s lot of thinking, and while I have gone into megadose thiamine therapy, I'm still in search for an alternative explanation for my current state of ataxia.

Serendipity stepped in lately, and I find myself going into my 4th week of being bedridden because my cat bit my ankle hard leaving me with a wound that won't heal. To make a long story short, a doctor I consulted (belatedly) told me wounds near bones (in my case the ankle bone) are more difficult to heal and he taught me the way to heal such wounds.

So anyway, I had spent a lot of time lying down all this time because it is painful to walk. While I won't know for sure, it seems all this lying down has made it easier for blood to flow to my brain, and I don't seem to have ataxia anymore.

I'm so sorry about your cat bite on your ankle! I've had a few cat bites myself, but they seem to always go for my fatty thighs. So no bones endangered.

It sounds like you've been given a clue all right. About the blood flow to your brain. Dr. Lonsdale talked about the part of dysautonomia that caused people to get dizzy and faint if they stood up too quickly which caused the blood to fall from their brains. Something about the autonomic nervous system controlling the tone of the blood vessels which is supposed to keep the blood flowing at a consistent pressure no matter the posture of the body.

It may be too good to be true, but maybe, just maybe, a little help from gravity may be all it takes.

It would be better if you could stand up and walk around....

Until my wound heals and I can go back to freely walking, there is no telling for sure.

Take a look at Dr. Lonsdale's book about dysautonomia here: https://www.sciencedirect.com/book/9780128103876/thiamine-deficiency-disease-dysautonomia-and-high-calorie-malnutrition

You're taking thiamine, right? What kind are you taking? How much?

DavidPS

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

To make a long story short, a doctor I consulted (belatedly) told me wounds near bones (in my case the ankle bone) are more difficult to heal and he taught me the way to heal such wounds.

Blood flow into the region below the calf and above the ankle is very poor. Older people lose their body hair in this region. Some bioenergetic things that increase blood flow are red and green lights, PEMF and carbon dioxide.

THE ROLE OF LIGHT EMITTING DIODE IN WOUND HEALING: A SYSTEMATIC REVIEW OF EXPERIMENTAL STUDIES

An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healing

AB0577 EFFECT OF TRANSCUTANEOUS CARBON DIOXIDE THERAPY FOR WOUND HEALING AFTER FOREFOOT SURGERY IN RHEUMATOID ARTHRITIS PATIENTS

yerrag

@mostlylurking

Yes, I'm taking thiamine HCl at 1500mg/day, but being in a bedridden position for a while seems to be healing me with blood flow improved going to the brain and fixing me of ataxia.

DavidPS

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

So anyway, I had spent a lot of time lying down all this time because it is painful to walk. While I won't know for sure, it seems all this lying down has made it easier for blood to flow to my brain, and I don't seem to have ataxia anymore.

Movement is very important for healing. Consider finding the minimum dose of time lying down to send your ataxia into remission.

Couch potatoes loose muscle mass and bone mass. Too much inactivity will make you frail very quickly and it is difficult to restore their levels. It is difficult to tell what is happening. I have been using a biometric scale for almost 10 years and my bone weight is higher than when I started recording bone weight.

Using a Biometric scale to infer changes in bone health over time. (N=1)

DavidPS

@mostlylurking - Thanks for the information. I am looking into thiamine and have increased my dosage.

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking

Yes, I'm taking thiamine HCl at 1500mg/day, but being in a bedridden position for a while seems to be healing me with blood flow improved going to the brain and fixing me of ataxia.

@yerrag Can you tell me how much you weigh? I'm following Dr. Costantini's protocol and according to my weight (150 lbs), I need 2 grams/day, divided into 2 doses, taken with water, mid morning, and then again mid afternoon.

I did not achieve my best response until I increased the dose to Dr. Costantini's recommended amount. When I increased from 1500mgs/day up to 2 grams/day I had a most notable improvement within 2 days; my entire digestive tract normalized.

"Finding the Correct Dose

The correct dose varies on the basis of:

Duration of the disease (the longer is the duration of the disease, the higher will be in general the doses;

Severity of the symptoms and rate of progression of the disease; Weight and physical characteristics of the patient sensitivity/responsiveness to the treatment.

In order to determine the right dose, we usually stick to the following protocol:

In case of recent onset of the disease in patients whose weight is between 50 to 65 kg (110 – 145 lbs), we begin the therapy with two grams of thiamine per day, before and after lunch.

In case the patient weighs more, the dose can be three grams per day, always divided into two administrations.

Oral thiamine should not be taken with juices or any sour beverage, water only.

The equivalent Intramuscular administration of thiamine would be:

For 2 grams/day orally = 1 x 100mg injectable solution per week;
For 3 grams/day orally = 2 x 75mg injectable solution per week;
For 4 grams/day orally = 2 x 100 mg injectable solution per week.

NOTE: When it is administrated through intramuscular injections treatment could lead to allergic reactions (we observed 4 cases in 2,500+ patients). Mainly there are dermatological rushes and allergic phenomena. "

from here: https://highdosethiamine.org/hdt-therapy/

@DavidPS said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking - Thanks for the information. I am looking into thiamine and have increased my dosage.

you're welcome.

yerrag

@DavidPS

I'm still doing some moving and thanks for reminding me. I once was confined to total bedrest after a car accident for a month. My legs had atrophied and I had lost temporarily my walking ability when I was discharged. I WS in my twenties then.My legs became skinny but I was amazed it didn't take long for my very developed calves to gain back its tone and mass. Talk about memory!

yerrag

@mostlylurking

I weigh about 150 lbs.

The reason I am willing to consider lying down as therapeutic was because I had been hypoxic due to my lung issue. Being deprived of oxygen, many red blood cells died as s result and my blood vessels are clogged with sludge from dead red blood cells that is still being cleared by the body. A lymph gland is still swollen as well. My lungs still give out clear or white phlegm and I suspect the lungs is helping clear red dead blood cells, although a lot of gallbladder activity is going on during sleep clearing dead red blood cells.

I am not a doctor definitely but I can observe and don't take lightly these observations. Though you may not take this observation as seriously (who would?), it is a habit I have developed that has served me well over the years.

But if my neurological condition is from blood flow simply not being adequate to the brain, it is possible because I have a lot of of sludge that impedes the flow.

I track my ESR, and my ESR has been much high higher ever since my lung issue began, and I believe it is the sludge causing my ESR to be that high. My ESR was perfect at zero 5 years ago when I began tracking it over the years. So as s thinking man who doesn't restrict oneself to studies made by others I have to entertain this possibility, which In consider more of a probability.

I thought you should also be open even though you have invested a lot on the invincibility of the mega dosing thiamine idea. Time will tell, and when my wound heals, and if I still retain my ataxic condition, then I will retreat on my hunch.

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking

I weigh about 150 lbs.

OK; so your Dr. Costantini recommended dose would be 2 grams/day, same as me. He explained that 2 grams of thiamine hcl, taken orally per day for 7 days, equals the same dose as a single 100mg injection of thiamine hcl. This is because of the poor absorption rate when taking the hcl type orally. I think that this assumes that the person has reasonably OK intestinal function. Some people would need more, but I couldn't tolerate more. I tried a higher dose one time (2.5 grams) in a day; it gave me shooting electrical zapping pains in my thighs that night.

The reason I am willing to consider lying down as therapeutic was because I had been hypoxic due to my lung issue. Being deprived of oxygen, many red blood cells died as s result and my blood vessels are clogged with sludge from dead red blood cells that is still being cleared by the body. A lymph gland is still swollen as well. My lungs still give out clear or white phlegm and I suspect the lungs is helping clear red dead blood cells, although a lot of gallbladder activity is going on during sleep clearing dead red blood cells.

How much time has passed since your hypoxia/lung injury? I'm left with the idea that this has been a longer term situation? Are you seeing slow improvement over all? Or have you plateaued?

I am not a doctor definitely but I can observe and don't take lightly these observations. Though you may not take this observation as seriously (who would?), it is a habit I have developed that has served me well over the years.

You know your body better than anyone. It is wise to take seriously information perceived from your body. I do the same thing.

But if my neurological condition is from blood flow simply not being adequate to the brain, it is possible because I have a lot of of sludge that impedes the flow.

Can you say how long a time this sludge issue has been going on?

Do you believe that your lungs are permanently injured or do you believe that healing/improvement in lung function is possible/happening?

I track my ESR, and my ESR has been much high higher ever since my lung issue began, and I believe it is the sludge causing my ESR to be that high. My ESR was perfect at zero 5 years ago when I began tracking it over the years. So as s thinking man who doesn't restrict oneself to studies made by others I have to entertain this possibility, which In consider more of a probability.

I found this article about clearing dead cells; perhaps you might find it of interest?
Mechanisms and physiology of the clearance of dead cells by efferocytosis

I thought you should also be open even though you have invested a lot on the invincibility of the mega dosing thiamine idea. Time will tell, and when my wound heals, and if I still retain my ataxic condition, then I will retreat on my hunch.

I hope your wound heals quickly and that your improvement continues.

yerrag

@mostlylurking said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking

I weigh about 150 lbs.

OK; so your Dr. Costantini recommended dose would be 2 grams/day, same as me. He explained that 2 grams of thiamine hcl, taken orally per day for 7 days, equals the same dose as a single 100mg injection of thiamine hcl. This is because of the poor absorption rate when taking the hcl type orally. I think that this assumes that the person has reasonably OK intestinal function. Some people would need more, but I couldn't tolerate more. I tried a higher dose one time (2.5 grams) in a day; it gave me shooting electrical zapping pains in my thighs that night.

I'm taking 2000mg daily thiamine HCl and I could take it. I have not tried increasing the dosage. I am now taking it together with 200mg niacin (no more itches after s period of adjustment), 100mg b6, and 15mg b2 (lowered as I felt weight gain at a higher dosage).

The reason I am willing to consider lying down as therapeutic was because I had been hypoxic due to my lung issue. Being deprived of oxygen, many red blood cells died as a result and my blood vessels are clogged with sludge from dead red blood cells that is still being cleared by the body. A lymph gland is still swollen as well. My lungs still give out clear or white phlegm and I suspect the lungs is helping clear red dead blood cells, although a lot of gallbladder activity is going on during sleep clearing dead red blood cells.

How much time has passed since your hypoxia/lung injury? I'm left with the idea that this has been a longer term situation? Are you seeing slow improvement over all? Or have you plateaued?

My lung injury started Feb last year. It has been resolved since March this year. I am breathing normally now. I used suppositories of essential oils and it healed my lungs, which I don't believe my pulmologist is trained to do.
I am not a doctor definitely but I can observe and don't take lightly these observations. Though you may not take this observation as seriously (who would?), it is a habit I have developed that has served me well over the years.

You know your body better than anyone. It is wise to take seriously information perceived from your body. I do the same thing.
Thanks. It helps as far too often we are told by doctors that they know better.

But if my neurological condition is from blood flow simply not being adequate to the brain, it is possible because I have a lot of of sludge that impedes the flow.

Can you say how long a time this sludge issue has been going on?
I would say since my lungs started breathing poorly and my spO2 levels began to drop to lower levels to not be able to adequately provided oxygen to my tissues. I think the body would prefer to sacrifice my red blood cells than cause my organ tissues to be destroyed, as rbc's can be replenished once the crisis is over. And the crisis is over, and the body is in the process of bouncing back to health.
Do you believe that your lungs are permanently injured or do you believe that healing/improvement in lung function is possible/happening?
Lungs have already healed. I think being better nourished for such an event made my lungs heal much more quickly. I had been eating 4 lbs of beef tendon monthly for a while for its cleaner gelatin content, and this has provides MW with ample glutathione needed as antioxidant protection as well as to make sure I have sufficient sulfhydryl bonds needed to effect clearing of phlegm with the thin mucus enabled by sulfhydryl bonds.

I track my ESR, and my ESR has been much high higher ever since my lung issue began, and I believe it is the sludge causing my ESR to be that high. My ESR was perfect at zero 5 years ago when I began tracking it over the years. So as s thinking man who doesn't restrict oneself to studies made by others I have to entertain this possibility, which In consider more of a probability.

I found this article about clearing dead cells; perhaps you might find it of interest?
Mechanisms and physiology of the clearance of dead cells by efferocytosis

Thank you. I have been looking for such info.

I thought you should also be open even though you have invested a lot on the invincibility of the mega dosing thiamine idea. Time will tell, and when my wound heals, and if I still retain my ataxic condition, then I will retreat on my hunch.

I hope your wound heals quickly and that your improvement continues.
I appreciate very much your concern and support.

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking

I weigh about 150 lbs.

OK; so your Dr. Costantini recommended dose would be 2 grams/day, same as me. He explained that 2 grams of thiamine hcl, taken orally per day for 7 days, equals the same dose as a single 100mg injection of thiamine hcl. This is because of the poor absorption rate when taking the hcl type orally. I think that this assumes that the person has reasonably OK intestinal function. Some people would need more, but I couldn't tolerate more. I tried a higher dose one time (2.5 grams) in a day; it gave me shooting electrical zapping pains in my thighs that night.

I'm taking 2000mg daily thiamine HCl and I could take it. I have not tried increasing the dosage. I am now taking it together with 200mg niacin (no more itches after s period of adjustment), 100mg b6, and 15mg b2 (lowered as I felt weight gain at a higher dosage).

I'll share with you what I am taking; perhaps it will help? (Maybe not; we're all different.)
thiamine hcl, 1 gram, 2 times a day (mid-morning, mid-afternoon)
niacinamide, 100mgs, 4 times a day
riboflavin (b2), 100mgs, 4 times a day
b6, about 25-30mgs, 1 time a day
b5, about 100mgs, 1 time a day
biotin, about 30-45mgs(?) 1 time a day
D3, 10,000iu, 1 time a day
k2, 15mgs, 1 time a day
NAC, about 50-100mgs, 1 time a day
selenium, 200mcgs, every other day
zinc, 15 mgs, 1 time a day
135mgs prescription desiccated thyroid (NP Thyroid by Acella), 1time a day

My eyes have improved on the 400mgs/day of b2. The cataracts have gotten better (I'm 74; was told 10 years ago I'd need cataract surgery "soon"). There's some interesting research about b2. Also, my endocrinologist (80+years old) focused on b2 when he got his doctorate; he told me if I wanted to take it to go ahead as it wouldn't hurt me.

Here's an article or 3 (from my collection) for your consideration:
Riboflavin: The Health Benefits of a Forgotten Natural Vitamin

RIBOFLAVIN, A TESTOSTERONE 5α-REDUCTASE INHIBITOR

A newly discovered anti-senescence function of vitamin B2

The reason I am willing to consider lying down as therapeutic was because I had been hypoxic due to my lung issue. Being deprived of oxygen, many red blood cells died as a result and my blood vessels are clogged with sludge from dead red blood cells that is still being cleared by the body. A lymph gland is still swollen as well. My lungs still give out clear or white phlegm and I suspect the lungs is helping clear red dead blood cells, although a lot of gallbladder activity is going on during sleep clearing dead red blood cells.

How much time has passed since your hypoxia/lung injury? I'm left with the idea that this has been a longer term situation? Are you seeing slow improvement over all? Or have you plateaued?

My lung injury started Feb last year. It has been resolved since March this year. I am breathing normally now. I used suppositories of essential oils and it healed my lungs, which I don't believe my pulmologist is trained to do.
I am not a doctor definitely but I can observe and don't take lightly these observations. Though you may not take this observation as seriously (who would?), it is a habit I have developed that has served me well over the years.

You know your body better than anyone. It is wise to take seriously information perceived from your body. I do the same thing.
Thanks. It helps as far too often we are told by doctors that they know better.

Except for my 80+ year old endocrinologist, I don't think doctors know diddly squat. And my poor endocrinologist is so harassed by whatever agency is looking over his shoulder he's afraid to practice medicine like he wants to. Things have gotten pretty sad.

But if my neurological condition is from blood flow simply not being adequate to the brain, it is possible because I have a lot of of sludge that impedes the flow.

Can you say how long a time this sludge issue has been going on?
I would say since my lungs started breathing poorly and my spO2 levels began to drop to lower levels to not be able to adequately provided oxygen to my tissues. I think the body would prefer to sacrifice my red blood cells than cause my organ tissues to be destroyed, as rbc's can be replenished once the crisis is over. And the crisis is over, and the body is in the process of bouncing back to health.
Do you believe that your lungs are permanently injured or do you believe that healing/improvement in lung function is possible/happening?
Lungs have already healed. I think being better nourished for such an event made my lungs heal much more quickly. I had been eating 4 lbs of beef tendon monthly for a while for its cleaner gelatin content, and this has provides MW with ample glutathione needed as antioxidant protection as well as to make sure I have sufficient sulfhydryl bonds needed to effect clearing of phlegm with the thin mucus enabled by sulfhydryl bonds.

Glad to learn your lungs have healed.

I was unable to tolerate taking TTFD thiamine because my glutathione level was very low. TTFD uses glutathione to work (somehow, some way). So I took high dose thiamine hcl instead. After about 4 months of taking 2 grams/day, I got my glutathione tested and it was in the normal range for the first time in decades. Elliot Overton recommended thiamine hcl; he said in a video that it would normalize glutathione levels and he was right about that.

I think my glutathione level was low for so long because of the high oxidative stress that was caused by my mercury toxicity. I think the thiamine resolved the oxidative stress which took the load off of my glutathione.

I track my ESR, and my ESR has been much high higher ever since my lung issue began, and I believe it is the sludge causing my ESR to be that high. My ESR was perfect at zero 5 years ago when I began tracking it over the years. So as s thinking man who doesn't restrict oneself to studies made by others I have to entertain this possibility, which In consider more of a probability.

I found this article about clearing dead cells; perhaps you might find it of interest?
Mechanisms and physiology of the clearance of dead cells by efferocytosis

Thank you. I have been looking for such info.

you're welcome. Do you ever use Google Scholar for researching? I've found it very helpful.

@yerrag Well, oops. I took the time to write down my supplements and I left out the magnesium glycinate: 3500mgs/day = 400 mgs of pure magnesium. I knew I had forgotten something.... And magnesium is important.

yerrag

@mostlylurking

I got to read the article on efferocytosis. It is a good read, though like most of these articles we get, they're a hard read as it's hard to keep up the different names of enzymes and proteins and what not involved. They get too detailed beyond what is practical for us to use. I get to wonder often if doctors actually read to such detail as they hardly find them to read and rather go to Hawaiian resorts for all+expenses paid symposiums. And they get a nice spiel and summary from their med reps. I would prefer they present these things in a black box way, without too much detail. Honestly, I just brush thru these articles because I feel the law of diminishing returns at work when I have to be thorough finishing such articles. Still, I'm disappointed the article leaves out mention of hemolyzed red blood cells and how they are disposed.

One not I have with such publications is that they talk too much unnecessary detail that they lose the forest for the trees. They are heavy on the ABC's and light on the why's and wherefore's that forms a cause and effect narrative on disease. It is mainly useless circumlocution that gets the reader no nowhere. Perhaps that is the intent- to make us go around in an endless circle of meaningless twiddling and twaddling.

Perhaps I have been spoiled by Peat, as he cuts through that wasteland and skims it of its gems and summarizes the studies for us. And I still find it more rewarding to read the articles and books that I have not read. And there's a lot of material left of his I have to read up on.

Thanks for the effort compiling the supplements you take, though I have to admit I have moved on from taking a lot of supplements as it was my intent to seek nutrients from food when I go back to my country. As the nice thing about backward countries is the diversity of the food supply chain which still allows me to get nutrients from food that is typically missing in the US.

The B-vitamins and Vitamin E and C are the only exceptions.

And I have benefited from this strategy. Like you, my eyesight has improved within a 5-yr span from starting to eat beef liver weekly. The retinol it provides is what I consider real vitamin A as opposed to the beta-carotene almost always pushed by supplement companies. A sister of mine who sells and also uses supplements for a well-known supplement marketing company, Shaklee, has been faithfully using its products yet her eyesight is no better that in fact her eye doctor is telling her she would be due for cataract surgery in the near future. No wonder, Shaklee considers beta-carotene to be the only vitamin A in their supplements.

But me, I am no longer required to wear glasses to drive and I still easily read the small type from my cellphone. And this is coming from where I had been prescribed bifocals 15 years back.

Which is why I consider the medical system a Rube Goldberg system that I always seek to find an alternate and simpler for. In many ways, health forums such as ours are unavoidably thus infected with the creep from our games medical system. This makes me decide to limit digging to deep into the medical literature wasteland, as it is designed to make us go in circles for a solution.

I'm more focused on connecting the dots from reading and benefiting from disinterested medical tomes from Peat, Long, St Gyorgi et all than from commercially vetted and supported research works that form a larger part of the wasteland.

I sigh with dismay when we continue to talk of cell membranes, and accept the use of HbA1c as a valid marker for blood sugar health when Ray has pointed out how poorly it represent our blood sugar health. And we are so close-minded that we are tribal in the sense that this forum has never wanted to consider the use of urine pH and saliva pH as a proxy marker for metabolic health, still following the beat of the pied piper of mainstream medicine. Just because the pied piper says so.

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking

I got to read the article on efferocytosis. It is a good read, though like most of these articles we get, they're a hard read as it's hard to keep up the different names of enzymes and proteins and what not involved. They get too detailed beyond what is practical for us to use. I get to wonder often if doctors actually read to such detail as they hardly find them to read and rather go to Hawaiian resorts for all+expenses paid symposiums. And they get a nice spiel and summary from their med reps. I would prefer they present these things in a black box way, without too much detail. Honestly, I just brush thru these articles because I feel the law of diminishing returns at work when I have to be thorough finishing such articles. Still, I'm disappointed the article leaves out mention of hemolyzed red blood cells and how they are disposed.

You noticed. I agree with you. But once in a while I stumble upon a gem of an article that is actually insightful and helpful. This happens mainly in articles written for veterinary research, including for the fishing industry. Here's an example: Fatty acid signatures connect thiamine deficiency with the diet of the Atlantic salmon (Salmo salar) feeding in the Baltic Sea Go down to the Conclusions: "As Keinänen et al. (2017) suggested, fatty young sprat specimens, when abundantly preyed on by salmon, easily overload them, particularly with highly unsaturated DHA, thereby predisposing them to oxidative stress, which results in the depletion of thiamine." That right there made it worth it to me to slog through the article. The fisheries solved the die off problem by adding thiamine to the water for the salmon hatchlings.

Research for humans is really horrible. I get sent notifications for new papers released about hypothyroidism; about 99% of them are bought and paid for papers that try to shore up the American Thyroid Association's position that T3 isn't needed (except for very rare occasions) and synthetic T4 alone is the "proper" treatment. The ATA should be RICOed.

One not I have with such publications is that they talk too much unnecessary detail that they lose the forest for the trees. They are heavy on the ABC's and light on the why's and wherefore's that forms a cause and effect narrative on disease. It is mainly useless circumlocution that gets the reader no nowhere. Perhaps that is the intent- to make us go around in an endless circle of meaningless twiddling and twaddling.

I've noticed that they also consistently make erroneous assumptions and then base the rest of the paper on those assumptions. It's really terrible. Also why in the world do they insist on using thousands of initials for thousands of technical words/things? It makes reading the paper impossible. But I think that's the point.

Perhaps I have been spoiled by Peat, as he cuts through that wasteland and skims it of its gems and summarizes the studies for us. And I still find it more rewarding to read the articles and books that I have not read. And there's a lot of material left of his I have to read up on.

Peat's papers were a godsend for me. Although they aren't easy to read, multiple readings made for better understanding. Peat actually had things to say, truths you can sink your teeth into. I'm much better able to discern if someone else's paper is worth struggling through now after studying Ray Peat's work.

Thanks for the effort compiling the supplements you take, though I have to admit I have moved on from taking a lot of supplements as it was my intent to seek nutrients from food when I go back to my country. As the nice thing about backward countries is the diversity of the food supply chain which still allows me to get nutrients from food that is typically missing in the US.

That's good about your country's food supply; I hope you can return to it so that you may benefit from it.

The B-vitamins and Vitamin E and C are the only exceptions.

And I have benefited from this strategy. Like you, my eyesight has improved within a 5-yr span from starting to eat beef liver weekly. The retinol it provides is what I consider real vitamin A as opposed to the beta-carotene almost always pushed by supplement companies. A sister of mine who sells and also uses supplements for a well-known supplement marketing company, Shaklee, has been faithfully using its products yet her eyesight is no better that in fact her eye doctor is telling her she would be due for cataract surgery in the near future. No wonder, Shaklee considers beta-carotene to be the only vitamin A in their supplements.

I was overloaded with beta-carotene when I found Peat's work in 2014. I'm very sensitive to it, not in a good way.

But me, I am no longer required to wear glasses to drive and I still easily read the small type from my cellphone. And this is coming from where I had been prescribed bifocals 15 years back.

My vision history is very similar. I no longer have to wear glasses to drive. but I do need to grab my readers to read small print; I'm 74, after all.

Which is why I consider the medical system a Rube Goldberg system that I always seek to find an alternate and simpler for. In many ways, health forums such as ours are unavoidably thus infected with the creep from our games medical system. This makes me decide to limit digging to deep into the medical literature wasteland, as it is designed to make us go in circles for a solution.

To me, a Rube Goldberg system implies a lack of sinister purpose and more a cobbling things together in ignorant bliss. The business of still filling people's teeth with mercury in this day and age is inexcusable. Likewise the intentional destruction of treatment for hypothyroidism with desiccated thyroid while banishing food sources of thyroid. Likewise the promotion of PUFA as "heart healthy". I could go on, but I'm sure you get the point. We're not witnessing innocent stupidity.

I'm more focused on connecting the dots from reading and benefiting from disinterested medical tomes from Peat, Long, St Gyorgi et all than from commercially vetted and supported research works that form a larger part of the wasteland.

I agree; it's a much better way to use your time.

I sigh with dismay when we continue to talk of cell membranes, and accept the use of HbA1c as a valid marker for blood sugar health when Ray has pointed out how poorly it represent our blood sugar health. And we are so close-minded that we are tribal in the sense that this forum has never wanted to consider the use of urine pH and saliva pH as a proxy marker for metabolic health, still following the beat of the pied piper of mainstream medicine. Just because the pied piper says so.

I'm hoping that we will get to witness the destruction of Rockefeller medicine, the medical industrial complex, and most especially the pharmaceutical industry. Sooner rather than later would be good. Before the total decimation of the human race is an accomplished fact. Here's a video about our medical complex's problem; set to start at the Rockefeller chapter.

yerrag

@mostlylurking said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking

I got to read the article on efferocytosis. It is a good read, though like most of these articles we get, they're a hard read as it's hard to keep up the different names of enzymes and proteins and what not involved. They get too detailed beyond what is practical for us to use. I get to wonder often if doctors actually read to such detail as they hardly find them to read and rather go to Hawaiian resorts for all+expenses paid symposiums. And they get a nice spiel and summary from their med reps. I would prefer they present these things in a black box way, without too much detail. Honestly, I just brush thru these articles because I feel the law of diminishing returns at work when I have to be thorough finishing such articles. Still, I'm disappointed the article leaves out mention of hemolyzed red blood cells and how they are disposed.

You noticed. I agree with you. But once in a while I stumble upon a gem of an article that is actually insightful and helpful. This happens mainly in articles written for veterinary research, including for the fishing industry. Here's an example: Fatty acid signatures connect thiamine deficiency with the diet of the Atlantic salmon (Salmo salar) feeding in the Baltic Sea Go down to the Conclusions: "As Keinänen et al. (2017) suggested, fatty young sprat specimens, when abundantly preyed on by salmon, easily overload them, particularly with highly unsaturated DHA, thereby predisposing them to oxidative stress, which results in the depletion of thiamine." That right there made it worth it to me to slog through the article. The fisheries solved the die off problem by adding thiamine to the water for the salmon hatchlings.

Yes! I think, with the exception of false rabies shots, vets have been better care of animals than doctors have been taking care of humans.

Research for humans is really horrible. I get sent notifications for new papers released about hypothyroidism; about 99% of them are bought and paid for papers that try to shore up the American Thyroid Association's position that T3 isn't needed (except for very rare occasions) and synthetic T4 alone is the "proper" treatment. The ATA should be RICOed.

It is really a racket. But racketeers are our overlords, so such evident rackets become accepted as the norm.

One nit I have with such publications is that they talk too much unnecessary detail that they lose the forest for the trees. They are heavy on the ABC's and light on the why's and wherefore's that forms a cause and effect narrative on disease. It is mainly useless circumlocution that gets the reader no nowhere. Perhaps that is the intent- to make us go around in an endless circle of meaningless twiddling and twaddling.

I've noticed that they also consistently make erroneous assumptions and then base the rest of the paper on those assumptions. It's really terrible. Also why in the world do they insist on using thousands of initials for thousands of technical words/things? It makes reading the paper impossible. But I think that's the point.

To keep us second-guessing and paralyzed in such a way we become so reliant on their "experts" to save us.

Perhaps I have been spoiled by Peat, as he cuts through that wasteland and skims it of its gems and summarizes the studies for us. And I still find it more rewarding to read the articles and books that I have not read. And there's a lot of material left of his I have to read up on.

Peat's papers were a godsend for me. Although they aren't easy to read, multiple readings made for better understanding. Peat actually had things to say, truths you can sink your teeth into. I'm much better able to discern if someone else's paper is worth struggling through now after studying Ray Peat's work.

I feel as guided as you are by having read and understood his writing. I am not as blind and less given to be led by the pied pipers.

Thanks for the effort compiling the supplements you take, though I have to admit I have moved on from taking a lot of supplements as it was my intent to seek nutrients from food when I go back to my country. As the nice thing about backward countries is the diversity of the food supply chain which still allows me to get nutrients from food that is typically missing in the US.

That's good about your country's food supply; I hope you can return to it so that you may benefit from it.

I have been back to my country for 16 years already. The control of pharma is much much less even if the Philippines is a total tributary state of the Evil Empire. It is much poorer but being poorer makes it less a fertile ground to be fleeced by the racketeers.

The B-vitamins and Vitamin E and C are the only exceptions.

And I have benefited from this strategy. Like you, my eyesight has improved within a 5-yr span from starting to eat beef liver weekly. The retinol it provides is what I consider real vitamin A as opposed to the beta-carotene almost always pushed by supplement companies. A sister of mine who sells and also uses supplements for a well-known supplement marketing company, Shaklee, has been faithfully using its products yet her eyesight is no better that in fact her eye doctor is telling her she would be due for cataract surgery in the near future. No wonder, Shaklee considers beta-carotene to be the only vitamin A in their supplements.

I was overloaded with beta-carotene when I found Peat's work in 2014. I'm very sensitive to it, not in a good way.

But me, I am no longer required to wear glasses to drive and I still easily read the small type from my cellphone. And this is coming from where I had been prescribed bifocals 15 years back.

My vision history is very similar. I no longer have to wear glasses to drive. but I do need to grab my readers to read small print; I'm 74, after all.

It may be that you are sufficient in retinol, but need more endogenous CO2 production. Just a guess.

As CO2 abundance is needed for good vision as well. With optimal sugar metabolism, CO2 abundance is assured.

Two proxies I use to ensure I am optimal metabolically is acid-base balance and good blood sugar requisition. IMHO, all other testing is just superfluous.

Testing for those two can be done at home, at a miniscule fraction of the cost.

Which is why I consider the medical system a Rube Goldberg system that I always seek to find an alternate and simpler for. In many ways, health forums such as ours are unavoidably thus infected with the creep from our games medical system. This makes me decide to limit digging to deep into the medical literature wasteland, as it is designed to make us go in circles for a solution.

To me, a Rube Goldberg system implies a lack of sinister purpose and more a cobbling things together in ignorant bliss. The business of still filling people's teeth with mercury in this day and age is inexcusable. Likewise the intentional destruction of treatment for hypothyroidism with desiccated thyroid while banishing food sources of thyroid. Likewise the promotion of PUFA as "heart healthy". I could go on, but I'm sure you get the point. We're not witnessing innocent stupidity.

Rackets sprockets.

I'm more focused on connecting the dots from reading and benefiting from disinterested medical tomes from Peat, Long, St Gyorgi et all than from commercially vetted and supported research works that form a larger part of the wasteland.

I agree; it's a much better way to use your time.

I sigh with dismay when we continue to talk of cell membranes, and accept the use of HbA1c as a valid marker for blood sugar health when Ray has pointed out how poorly it represent our blood sugar health. And we are so close-minded that we are tribal in the sense that this forum has never wanted to consider the use of urine pH and saliva pH as a proxy marker for metabolic health, still following the beat of the pied piper of mainstream medicine. Just because the pied piper says so.

I'm hoping that we will get to witness the destruction of Rockefeller medicine, the medical industrial complex, and most especially the pharmaceutical industry. Sooner rather than later would be good. Before the total decimation of the human race is an accomplished fact. Here's a video about our medical complex's problem; set to start at the Rockefeller chapter.

That will only happen when the US military is swallowed by the Red Sea.

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@yerrag said in The role of cerebral blood flow in the pathogenesis of Alzheimer's Disease Dementia:

@mostlylurking

I got to read the article on efferocytosis. It is a good read, though like most of these articles we get, they're a hard read as it's hard to keep up the different names of enzymes and proteins and what not involved. They get too detailed beyond what is practical for us to use. I get to wonder often if doctors actually read to such detail as they hardly find them to read and rather go to Hawaiian resorts for all+expenses paid symposiums. And they get a nice spiel and summary from their med reps. I would prefer they present these things in a black box way, without too much detail. Honestly, I just brush thru these articles because I feel the law of diminishing returns at work when I have to be thorough finishing such articles. Still, I'm disappointed the article leaves out mention of hemolyzed red blood cells and how they are disposed.

You noticed. I agree with you. But once in a while I stumble upon a gem of an article that is actually insightful and helpful. This happens mainly in articles written for veterinary research, including for the fishing industry. Here's an example: Fatty acid signatures connect thiamine deficiency with the diet of the Atlantic salmon (Salmo salar) feeding in the Baltic Sea Go down to the Conclusions: "As Keinänen et al. (2017) suggested, fatty young sprat specimens, when abundantly preyed on by salmon, easily overload them, particularly with highly unsaturated DHA, thereby predisposing them to oxidative stress, which results in the depletion of thiamine." That right there made it worth it to me to slog through the article. The fisheries solved the die off problem by adding thiamine to the water for the salmon hatchlings.

Yes! I think, with the exception of false rabies shots, vets have been better care of animals than doctors have been taking care of humans.

I've found that vets (at least the ones I've gotten to know) are decent people who like animals. Modern day doctors, on the other hand, seem to consider people to be something like a commodity to extract money from.

Research for humans is really horrible. I get sent notifications for new papers released about hypothyroidism; about 99% of them are bought and paid for papers that try to shore up the American Thyroid Association's position that T3 isn't needed (except for very rare occasions) and synthetic T4 alone is the "proper" treatment. The ATA should be RICOed.

It is really a racket. But racketeers are our overlords, so such evident rackets become accepted as the norm.

But once you see it, you cannot unsee it. If you see it, you can take steps to defend yourself via learning (for free on the internet).

One nit I have with such publications is that they talk too much unnecessary detail that they lose the forest for the trees. They are heavy on the ABC's and light on the why's and wherefore's that forms a cause and effect narrative on disease. It is mainly useless circumlocution that gets the reader no nowhere. Perhaps that is the intent- to make us go around in an endless circle of meaningless twiddling and twaddling.

I've noticed that they also consistently make erroneous assumptions and then base the rest of the paper on those assumptions. It's really terrible. Also why in the world do they insist on using thousands of initials for thousands of technical words/things? It makes reading the paper impossible. But I think that's the point.

To keep us second-guessing and paralyzed in such a way we become so reliant on their "experts" to save us.

Once you see the game and "get it" then the wise saying comes into play: "Fool me once, shame on you; fool me twice, shame on me."

Perhaps I have been spoiled by Peat, as he cuts through that wasteland and skims it of its gems and summarizes the studies for us. And I still find it more rewarding to read the articles and books that I have not read. And there's a lot of material left of his I have to read up on.

Peat's papers were a godsend for me. Although they aren't easy to read, multiple readings made for better understanding. Peat actually had things to say, truths you can sink your teeth into. I'm much better able to discern if someone else's paper is worth struggling through now after studying Ray Peat's work.

I feel as guided as you are by having read and understood his writing. I am not as blind and less given to be led by the pied pipers.

Knowledge is power.

Thanks for the effort compiling the supplements you take, though I have to admit I have moved on from taking a lot of supplements as it was my intent to seek nutrients from food when I go back to my country. As the nice thing about backward countries is the diversity of the food supply chain which still allows me to get nutrients from food that is typically missing in the US.

That's good about your country's food supply; I hope you can return to it so that you may benefit from it.

I have been back to my country for 16 years already. The control of pharma is much much less even if the Philippines is a total tributary state of the Evil Empire. It is much poorer but being poorer makes it less a fertile ground to be fleeced by the racketeers.

I misunderstood you before; I thought you had traveled out of the Philippines.

The B-vitamins and Vitamin E and C are the only exceptions.

And I have benefited from this strategy. Like you, my eyesight has improved within a 5-yr span from starting to eat beef liver weekly. The retinol it provides is what I consider real vitamin A as opposed to the beta-carotene almost always pushed by supplement companies. A sister of mine who sells and also uses supplements for a well-known supplement marketing company, Shaklee, has been faithfully using its products yet her eyesight is no better that in fact her eye doctor is telling her she would be due for cataract surgery in the near future. No wonder, Shaklee considers beta-carotene to be the only vitamin A in their supplements.

I was overloaded with beta-carotene when I found Peat's work in 2014. I'm very sensitive to it, not in a good way.

But me, I am no longer required to wear glasses to drive and I still easily read the small type from my cellphone. And this is coming from where I had been prescribed bifocals 15 years back.

My vision history is very similar. I no longer have to wear glasses to drive. but I do need to grab my readers to read small print; I'm 74, after all.

It may be that you are sufficient in retinol, but need more endogenous CO2 production. Just a guess.

As CO2 abundance is needed for good vision as well. With optimal sugar metabolism, CO2 abundance is assured.

Yes about the need for CO2. If you are deficient in thiamine you cannot make CO2 via sugar metabolism; the end product is lactic acid instead of CO2. Thiamine acts as an enzyme cofactor in the process. Supplementing with thiamine hcl has corrected my inefficient oxidative metabolism and thus has restored my level of CO2.

Two proxies I use to ensure I am optimal metabolically is acid-base balance and good blood sugar requisition. IMHO, all other testing is just superfluous.

Testing for those two can be done at home, at a miniscule fraction of the cost.

Which is why I consider the medical system a Rube Goldberg system that I always seek to find an alternate and simpler for. In many ways, health forums such as ours are unavoidably thus infected with the creep from our games medical system. This makes me decide to limit digging to deep into the medical literature wasteland, as it is designed to make us go in circles for a solution.

To me, a Rube Goldberg system implies a lack of sinister purpose and more a cobbling things together in ignorant bliss. The business of still filling people's teeth with mercury in this day and age is inexcusable. Likewise the intentional destruction of treatment for hypothyroidism with desiccated thyroid while banishing food sources of thyroid. Likewise the promotion of PUFA as "heart healthy". I could go on, but I'm sure you get the point. We're not witnessing innocent stupidity.

Rackets sprockets.

I'm more focused on connecting the dots from reading and benefiting from disinterested medical tomes from Peat, Long, St Gyorgi et all than from commercially vetted and supported research works that form a larger part of the wasteland.

I agree; it's a much better way to use your time.

I sigh with dismay when we continue to talk of cell membranes, and accept the use of HbA1c as a valid marker for blood sugar health when Ray has pointed out how poorly it represent our blood sugar health. And we are so close-minded that we are tribal in the sense that this forum has never wanted to consider the use of urine pH and saliva pH as a proxy marker for metabolic health, still following the beat of the pied piper of mainstream medicine. Just because the pied piper says so.

I'm hoping that we will get to witness the destruction of Rockefeller medicine, the medical industrial complex, and most especially the pharmaceutical industry. Sooner rather than later would be good. Before the total decimation of the human race is an accomplished fact. Here's a video about our medical complex's problem; set to start at the Rockefeller chapter.

That will only happen when the US military is swallowed by the Red Sea.

I suspect the situation is on a positive tract; we just are not told all the details. It's a war, after all. An unconventional war with no news coverage. This week should prove interesting.