Is Vitamin A Deficiency Real?
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Here's a recent video of mine breaking down Grant Genereux's theory on vitamin A deficiency.
Let me know what you guys think!
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Hi, Miguel. I hope that you're well.
I recall an episode where professor Garrett admitted to be a faddist, adding that such days were finally over now that he found the ultimate culprit of health problems: poison A. Some months afterwards, he was onto the next target, and this time it was bile (then niacin, pyridoxin, methylene blue..).
But the diversion of attention was quite clever. Before waiting for his poison A depletion program to fail and customers to protest, he sneakily recentered his approach on liver and bile, broadening it to the lowering of toxins—an abstract concept, with perpetual exposure and many confounders—guaranteeing for him a safe and sustainable business in a foggy picture.
Grant set the wrong tone, but both are responsible for misleading and the extremism. A group of people already addressed the majority of their arguments in the past.
We have covered a lot in exhaustive discussions on macabrotenoids and poisonoids, with the origin and biosynthesis in plants and microbes (potential suppliers to a host), their differentiation (including colorless ones), occurrence in foods, digestion and release, interactions with meal components, interception by microbiota, absorption factors, conversion efficiency, regulatory controls, transport, storage (inside and outside the liver), their specific distribution in liver, size of organs and capacity, recirculation, historical levels in tissues, population status, conditions associated with lack or excess, metabolic pathways and backup routes, methods of elimination and the clearance rate depending on body load, change in excretion rate for conservation in scarcity, total reserves and estimates of their lasting, transformed and intact excretion, conjugation, nutrients involved in their metabolism and in defending against adverse effects from excess, the criteria for the RDA, the management in livestock and hypomobilization states, lab experiments and their limitations, natural and unnatural isotretinoin levels, nuclear receptors and their (alternative) ligands with respective concentrations and affinities, interaction between receptors, genomic and non-genomic effects, enzymatic and non-enzymatic reactions, anti- and pro-oxidant activity, their relative orientation in lipids of cells and recycling, the undetectable serum levels (that applies to other toxins too, kilcidiol is an example), the idiotic “aposematism” objection (colorful macabrotenoids signal threat, similar to strawberries), response to supplements in varying forms…
It was in vain for the poison A crowd. Their only take-away was to continue to take it away from the plate.
To treat macabrotenoids and poisonoids as poisons helps to be at ease with prolonged avoidance. Why own the intolerance and investigate the internal issue when we can reclassify a nutrient as a toxin? Who worries about a lead shortage? If anything, we have some stored for life.
People who benefit from the avoidance of poisons will continue to dismiss refutations until a practical measure is offered, one with good results that dispenses restriction.
The issue appears immunological in nature, likely involving disturbances at the lining of tissues (in special gut, lungs, and skin), that can be manipulated by limiting the availability of poisons. In Grant's case, he associates his exaggerated immune responses to poison A, as it’s involved in gene expression and not invariably tolerogenic, which is why he suspects that any food that provokes these responses in him has hidden poisonoic acid.
Of course, if we're going to invalidate the interpretation of an experiment by pointing out a dietary factor that was common to both groups, we can't accept adverse reactions to macabrotenoids as a mere consequence of malnutrition or the unintentional elimination of allergens as a satisfactory explanation. After all, we have a lot of malnourished people who tolerate poisons just fine (for example, Ray suggested that the addition of this toxin can have a sparing effect on protein), and exclusion diets that have in common the elimination of one component can be challenged, which they likely were.
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@Amazoniac said in Is Vitamin A Deficiency Real?:
The issue appears immunological in nature, likely involving disturbances at the lining of tissues (in special gut, lungs, and skin), that can be manipulated by limiting the availability of poisons. In Grant's case, he associates his exaggerated immune responses to poison A, as it’s involved in gene expression and not invariably tolerogenic, which is why he suspects that any food that provokes these responses in him has hidden poisonoic acid.
Allegedly the word thymus means "soul" in Greek and some ancient scholars believed it to be the seat. I'm only able to confirm that in fact it's sitting on it.
Love your writing as always Gus. Highly amusing, poetic and informative.
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It's great. Thank you Mike.
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"Well, yes sorry, it can take a long time, but please take up that long timeframe issue with God. I’ve also stated many times that this is not a quick and easy fix. This fact is well documented in the literature too.
More importantly, it’s also documented that the damage caused by vitamin A toxicity is often permanent. I’m hoping that’s not always accurate. But, in some cases it probably is." - GG
Interesting language.
Anyway. Retinaldehyde is amazing.
