Vitamin E reverses atherogenesis/CVD, independently of its antioxidant effects
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Mainstream medicine claims that once cardiovascular disease (CVD) is established, there is no way to reverse it. All one can do is try to inhibit further plaque formation in the hope of delaying the inevitable (vessel blockage/rupture, followed by heart attack and/or stroke). I have already found studies demonstrating that aspirin, in doses of 800mg+ daily can reduce already established atheroma (plaque) and prevent future CVD event. The study below found that vitamin E, in a human-equivalent dose of about 5mg/kg daily, also reduces atherogenesis and improves cardiac function, without displaying antioxidant effects. The role of vitamin E as PUFA antagonist is probably the main mechanism of action, together with its role as an inhibitor of the inflammation producing enzyme COX/LOX, and its inhibitory effects on the release of other inflammatory mediators such as TNF-a, IL-1 and IL-6.
https://pubmed.ncbi.nlm.nih.gov/38717284/
“…The impact of α-tocopherol on atherosclerosis is unclear and controversial. While some studies suggest potential benefits, such as antioxidant properties that may reduce oxidative stress, other studies indicate no significant preventive effects. The intricate interplay of various factors, including dosage, individual differences, and study methodologies, contributes to the ongoing uncertainty surrounding α-tocopherol’s role in atherosclerosis. Further research is needed to clarify its impact and establish clearer guidelines. Therefore, we aimed to evaluate the impact of α-tocopherol on atherogenesis in ApoE−/− fibrillin (Fbn)1C1039G/+ mice, which is a unique mouse model of advanced atherosclerosis with typical features, such as large necrotic cores, high levels of inflammation, and intraplaque neovascularization, that resemble the unstable phenotype of human plaques. ApoE−/− Fbn1C1039G+/− mice were fed a western-type diet (WD) supplemented with a high dose of α-tocopherol (500 mg/kg diet), while control mice were fed a WD containing a low dose of α-tocopherol (50 mg/kg diet). The high dose of α-tocopherol reduced plaque thickness and necrotic core area in the right common carotid artery (RCCA) after 24 weeks WD. Moreover, α-tocopherol decreased plaque formation and intraplaque neovascularization in the RCCA. In addition to its antiatherogenic effect, chronic supplementation of α-tocopherol improved cardiac function in ApoE−/− Fbn1C1039G/+ mice. However, chronic supplementation of α-tocopherol did not decrease lipid peroxidation. On the contrary, α-tocopherol acted as a prooxidant by increasing plasma levels of oxidized LDL and plaque malondialdehyde, an end product of lipid peroxidation. Our data indicate that α-tocopherol inhibits atherogenesis and improves cardiac function independent of its antioxidant properties.”
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@haidut thank you
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Too much of a good thing is bad?
There is no real danger with high dose vitamin E.
But high repeated doses of vitamin E inhibit platelet aggregation. Need to be compensate with K1.
If you are bleeding from the nose, it is because you lack vitamin K1. Beyond 800 IU of vitamin E, vitamin E is opposed to the action of vitamin K, probably because the carrier is identical.
Alpha-tocopherol is preferably stocked in the liver. (Kayden and Traber, 1993; Traber et al., 1990).
Every 72 hours would be fine with 400 UI (at least 2 toco). 20-25 UI are needed per day, according to Chris Masterjohn.More info on Vit E
https://mirzoune-ciboulette.forumactif.org/t30-vitamine-e-plus-qu-une-vitamine#60
Excerpt 1 (translator needed, in French):
Most studies show a beginning of preventive efficiency at doses of 100 IU /D in degenerative diseases. Braking of oxidative stress which is underlying the phenomena of senescence and the appearance of all degenerative pathologies: cardiovascular, cancers, osteoarthritis, osteoporosis, presbyacousis, cataract, macular degeneration, Parkinson and Alzheimer's diseases, etc…
Excerpt 2 :- Optimal contribution, without pathology, if under 40 years old: 100 IU per day.
- Contribution in case of supplementation in polyunsaturated fatty acids 100 IU per gram of EPA. - Therapeutic contribution: 400 - 500 IU every 5 days.
Mg/ UI conversion: 100 mg = 150 IU.
Personally, it’s 400 UI mixed toco every 3 days (+/ twice a week). 3x if inflammation.
Now Foods – E 400 – with mixed tocopherols. Softgels. + once a week K1 (mix K1 and K2).
Note: Vit K2 MK7 must be encapsulated (oxidation).
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