Thiamine prevents fatty liver
-
Experimentally, you can induce fatty liver by overfeeding fructose/sucrose.
However, animals overfed carbohydrates have a higher metabolic rate and demand more nutrients.
Thiamine (B1) completely prevented fatty liver from developing in sheep overfed sugar.
-
https://pmc.ncbi.nlm.nih.gov/articles/PMC7988776/
Link to the study to save time for anyone that stumbles across this in future. Interesting study, B1 not typically what you see mentioned to combat fatty liver.
The high calorie plus thiamine group actually had less fat in the liver than the low calorie sheep.
"We found that thiamine reduced the hepatic-fat content dramatically, decreased blood glucose levels, and increased the hepatic glycogen content. The weekly dose of thiamine employed here, i.e. 900–1500 mg per animal, is likely to be realistic when investigating its effect in other species of similar body weight, i.e. ∼70 kg (Table S2), such as humans. Yet, clearly additional investigations are required to determine the minimal effective dose, duration and frequency of therapy."
