"Adipose tissue retains an epigenetic memory of obesity after weight loss" (New study offers incite into the challenges facing people with a history of obesity - published in Nature)
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https://www.nature.com/articles/s41586-024-08165-7
In summary, it remains unresolved whether individual cells retain a metabolic memory and whether it is conferred through epigenetic mechanisms. Here, we set out to address this by first performing single-nucleus RNA sequencing (snRNA-seq) of AT from individuals living with obesity before and after significant WL, as well as lean, obese and formerly obese mice, confirming the presence of retained transcriptional changes, and, second, by characterizing the epigenome of mouse adipocytes, which revealed the long-term persistence of an epigenetic obesogenic memory.
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