Serotonin question

lobotomize-me

@alex155 it seems like it

Serotonergic neurons project widely throughout the CNS and modulate many different brain functions. Particularly important, but controversial, are the contributions of serotonin (5-HT) neurons to respiratory and thermoregulatory control. To better define the roles of 5-HT neurons in breathing and thermoregulation, we took advantage of a unique conditional knock-out mouse in which Lmx1b is genetically deleted in Pet1-expressing cells (Lmx1b(f/f/p)), resulting in near-complete absence of central 5-HT neurons. Here, we show that the hypercapnic ventilatory response in adult Lmx1b(f/f/p) mice was decreased by 50% compared with wild-type mice, whereas baseline ventilation and the hypoxic ventilatory response were normal. In addition, Lmx1b(f/f/p) mice rapidly became hypothermic when exposed to an ambient temperature of 4 degrees C, decreasing core temperature to 30 degrees C within 120 min. This failure of thermoregulation was caused by impaired shivering and nonshivering thermogenesis, whereas thermosensory perception and heat conservation were normal. Finally, intracerebroventricular infusion of 5-HT stimulated baseline ventilation, and rescued the blunted hypercapnic ventilatory response. These data identify a previously unrecognized role of 5-HT neurons in the CO(2) chemoreflex, whereby they enhance the response of the rest of the respiratory network to CO(2). We conclude that the proper function of the 5-HT system is particularly important under conditions of environmental stress and contributes significantly to the hypercapnic ventilatory response and thermoregulatory cold defense.

indeed it is fascinating (i didnt know this), but we as humans can rely on our on metabolism uncoupling and cell processes and brown fat to produce heat without us needed to shiver as much

here is why:
Organism Avg. Weight Avg. Surface Area Surface Area-to-Mass Ratio
Mouse ~20-30 g ~70-100 cm² ~3.5 cm²/g (very high)
Human 🧍‍️ ~70 kg ~18,000 cm² ~0.26 cm²/g (low)

we humans have a lot more cells inside us than cells outside us that absorb the low temperatures. slightly more than 10x then mice

lobotomize-me

@alex155 said in Serotonin question:

for those who are afraid of tryptophan and serotonin, this study about B. subtilis will be interesting, what bacteria should be avoided, but I assure you that you won't even be able to take a shit without serotonin... and for now I will continue to experiment on myself

B.subtilis has shown to be capable of secreting polymyxin, difficidin, subtilin, and mycobacillin.
https://microchemlab.com/microorganisms/bacillus-subtilis/

thus reducing overall unwanted bacteria.