Glaucoma may be a metabolic condition, vitamin B1 (thiamine) may treat it
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Just a few hours ago I did a post about myopia being metabolic in origin and, as such, pro-metabolic substances such as DHEA may treat it. I also did posts a few years ago showing that other pro-metabolic substances such as niacinamide (vitamin B3) and progesterone may also treat glaucoma, as well as cataracts, dry-eye syndrome, etc. The study below adds more evidence to the claim that glaucoma is a metabolic condition, by showing that vitamin B1 levels are low in glaucoma patients that supplementation with vitamin B1 (and/or agmatine, another pro-metabolic substance) may treat the condition. This suggests that vitamin B1 and B3, being highly water-soluble, may make a good eye-drop product for treating a number of eye conditions, by improving (glucose) metabolism (which is their primary role) both locally in the eye and systemically.
https://pubmed.ncbi.nlm.nih.gov/40402521/
Mizzou researcher discovers natural molecules that may help glaucoma patients
Mizzou researcher discovers natural molecules that may help glaucoma patients
“…In a recent study, his team discovered that glaucoma patients have less of two tiny molecules — agmatine and thiamine — in the clear fluid at the front of the eye, compared to those without glaucoma. Singh has identified that these molecules, known as metabolites, could be potential biomarkers that could be spotted to detect the disease early. “In several cases, people do not find out they have glaucoma until they are older and their eye pressure is elevated,” Singh, an assistant professor in the School of Medicine, said. “Our long-term goal is to see if doctors could one day do a simple blood test to check for these biomarkers. If they can, hopefully they will be able to catch the disease much earlier, before vision loss occurs, so patients can receive treatment sooner.” These two metabolites, agmatine and thiamine, could also make for potential glaucoma treatments. In one of his recent pre-clinical studies, Singh found that agmatine and thiamine have neuroprotective potential and can help protect RGCs from damage and loss of visual function. This means these molecules might help stop or slow down the progression of vision loss, making them possible candidates for future neuroprotective treatment for glaucoma as eye drops or supplements.”
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@haidut said in Glaucoma may be a metabolic condition, vitamin B1 (thiamine) may treat it:
The study below adds more evidence to the claim that glaucoma is a metabolic condition, by showing that vitamin B1 levels are low in glaucoma patients that supplementation with vitamin B1 (and/or agmatine, another pro-metabolic substance) may treat the condition. This suggests that vitamin B1 and B3, being highly water-soluble, may make a good eye-drop product for treating a number of eye conditions, by improving (glucose) metabolism (which is their primary role) both locally in the eye and systemically.
Thank you for the study, Haidut; and glad to see you posting here. Can it be assumed adding agmatine to these drops would be beneficial as well?
If time allows, I would be curious as to your thoughts on recipe ratios, storage, and lifespan when making these drops homemade: all ingredients mixed in water.
