Fisetin
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Fisetin lowers weight gain on high fat diet via mtor inhibition.
https://pubmed.ncbi.nlm.nih.gov/23517912/
Fisetin helps with NAFLD and liver steatosis; upregulates Sirt1 and AMPK.
https://pubmed.ncbi.nlm.nih.gov/30235452/
Peat quotes on fisetin:
"I would be inclined to use quinones other than thymoquinone for cancer, along with activated carbonyls such as fisetin., Several of the flavonoids of fruits and vegetables (rutin, naringenin, naringin, hesperetin, apigenin, fisetin, luteolin, quercetin, curcumin) have a catalytic prooxidant effect similar to that of vitamin C and aspirin."
"Among the common inhibitors of carbonic anhydrase are the mildly oxidizing flavonoids such as apigenin and fisetin, some polyphenols, vitamin Bl, vitamin D (Mras, et al., 2012), progesterone (partly by blocking the activation by estrogen and aldosterone ), and emodin."
"All of the effective treatments for
Covid-19 have had antiinflammatory
effects—angiotensin blockers, cinanserin (a
serotonin blocker), antihistamines, naringenin,
hesperidin, fisetin and other flavonoids (Clementi,
et al., 2021;""Choosing foods that contain substances that protect against the many known pro-inflammatory,
age-accelerating processes is relatively
simple—citrus fruits, for example, contain a great
variety of substances related to nobiletin, naringin,
fisetin, and quercetin, that inhibit the formation of
HSP (Hosokawa, et al., 1990; Morino, et al.,1997;
Kim, et al., 2015)."
