Rosacea
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What information is out there on improving or even curing rosacea?
There is this RP article on it: https://wiki.chadnet.org/rosacea-inflammation-and-aging-the-inefficiency-of-stress
He suggests it's due to a mitochondrial issue and shows how women with higher amounts of estrogen get rosacea more.
However, I have had rosacea for a long time, and even when I load up on androsterone (powerful AI) while taking pyrucet + niacinamide, all while not being a woman, it doesn't really go away. The only thing that's made it better is a special metronidazole cream from my dermatologist and I cannot find any info on that here or on RPF.
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Have you tried topical niacinamide?
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Try the topical red dicopperoxide. Or better yet, topical Cu(II)-(acetyl salicylate)2.
Association /= causation.
Estrogen is elevated to increase copper availability through enhanced ceruloplasmin synthesis and cellular copper uptake transporter. Women after menopause accumulate iron without being replete in copper to compensate for this wrt to their ferroportin 1 and superoxidedismutase etc.
In lab models rosacea is typically induced by administration of the antimicrobial peptide LL37. LL37 of course is a product of D3 isomerization to 1,25-OH-D3 and IFN-y to tackle infection or as a response to significant endoplasmic reticulum stress. Therefore it may just be a convenient but replacabe means for inducing local inflammation at the intracellular level.Anyhow it's amazing how much nonsense RP blasted out sometimes in a potpourri of the usual keywords and how he was all about the dangers of PUFA and iron and even in that linked article above mentioned that "it can spread the damage to other components of the mitochondria, including the cytochromes and the polyunsaturated fatty acids" but never once pointing to copper which is necessary to control the intracellular iron accumulation, the ferrophagy, the Fenton reaction, the resulting lipoxidation, the conversion to iron's safe and stable Fe3+, the folding and stabilization of the fatty acids for cytochrome c, control blood viscosity through keeping Factor VIII in check and last but not least of course the collagen and elastin crosslinking to maintain sufficiently thick and supple skin.
as for iron overload, impaired mitochondrial function, impaired cytochrome C and the mentioned functional oxygen deficiency enjoy:
from https://ashpublications.org/blood/article-pdf/48/1/77/579793/77.pdf
