Lifespan-Extending Endogenous Metabolites
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The article below discusses the state of the science for several of the lifespan-extending contenders, including:
- Taurine
- Betaine
- α-Ketoglutarate
- Oxaloacetate
- Hydrogen Sulfide
- Myo-Inositol
- NAD+
- Methionine
- Branched Chain Amino Acids
- Trehalose
- Spermidine
- Lipid-Related Metabolites
Lifespan-Extending Endogenous Metabolites (2025)
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Interestingly a lot of the benefits of dietary/protein restriction seem to be due to an endogenous increase inH2S synthesis.
It seems to have some beneficial effects for the ETC.
"H2S can stimulate mitochondrial respiration at sites downstream of common PMD-defective subunits, augmenting energy production, mitochondrial function and reducing cell death. "
https://www.sciencedirect.com/science/article/pii/S1043661824001245Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio said in Lifespan-Extending Endogenous Metabolites:
Interestingly a lot of the benefits of dietary/protein restriction seem to be due to an endogenous increase inH2S synthesis.
I am wondering if the endogenous increase is a compensatory mechanism for the lower protein.
Impact of diet on hydrogen sulfide production: implications for gut health (2023)
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@DavidPS said in Lifespan-Extending Endogenous Metabolites:
I am wondering if the endogenous increase is a compensatory mechanism for the lower protein.
I think it is. A compensation for the low levels of sulfur amino acids to be precise.
