Updated clinical trials of key anti‐aging therapeutics.
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This image shows theraputics that are worthy of costly clinical trials.

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review (2025)
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NMN looks very interesting because its sibling niacinamide is a cheap commodity yet has almost identical pharmacology.
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@DavidPS fisetin for the win !
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@engineer - Niacin looks better to me. It raises HDL and that it important. I lhave started collecting that reasons here:
https://bioenergetic.forum/topic/9082/hdl-and-cognition-in-neurodegenerative-disordersThe niacin flush is blown. It is temporary and if one slowly increases the amount of niacin it will fade to almost nothing. Taking aspirin reduces the flush. Eventually, the flushing stops.
https://www.medicalnewstoday.com/articles/niacin-flush -
@Mauritio - Your not alone the market is with you.

https://www.thebusinessresearchcompany.com/report/fisetin-global-market-reportI think it is over rated. This graph my indicate that the control diet was not very good. I have a very good diet and so I do not expect to get similar results from supplementation.

https://novoslabs.com/novos-anti-aging-longevity-supplement/fisetin-anti-aging-supplement-longevity/