The multifaceted nature of the cytokine IL-10
-
After hearing about the ill-effects of the cytokine storm during covid infections, I began to think of cytokines as being unhealthy. This article explains that the cytokine IL-10 has different effects at different times in the infection.
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling pathway. On the other hand, IL-10 can also have immunostimulating functions under certain conditions. Given the pivotal role of IL-10 in immune modulation, this cytokine could have relevant implications in pathologies characterized by hyperinflammatory state, such as cancer, or infectious diseases as in the case of COVID-19 and Post-COVID-19 syndrome. Recent evidence proposed IL-10 as a predictor of severity and mortality for patients with acute or post-acute SARS-CoV-2 infection. In this context, IL-10 can act as an endogenous danger signal, released by tissues undergoing damage in an attempt to protect the organism from harmful hyperinflammation.
-
@DavidPS Interesting IIRC L. Reuteri increases it and the testosterone increase was reliant on IL10 increase.
Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio - Thanks From AI
Effects of Lactobacillus reuteri
Lactobacillus reuteri (L. reuteri) is a well-studied probiotic known for its beneficial effects on gut health and immune function. Research indicates that L. reuteri can influence the production of IL-10 in several ways:
Immune Modulation: L. reuteri has been shown to enhance the production of IL-10, which helps to reduce inflammation and promote a balanced immune response.
Gut Microbiota Interaction: By modulating gut microbiota composition, L. reuteri can create an environment that favors the production of IL-10, contributing to improved gut health and reduced inflammatory conditions.
Clinical Studies: Some studies have reported that supplementation with L. reuteri leads to increased levels of IL-10, suggesting its potential role in managing inflammatory diseases.
How does Lactobacillus reuteri affect immune function beyond IL-10 production?
Lactobacillus reuteri enhances immune function by increasing phagocytic activity in macrophages and boosting the secretion of nitric oxide and prostaglandin E2, which are crucial for immune responses. It also produces antimicrobial molecules like reuterin, which helps inhibit pathogenic microorganisms, contributing to overall immune health.
