Klotho may lower oxphos increase lactate..
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https://pubmed.ncbi.nlm.nih.gov/29493420/
The study looks at how neuronal Klotho, particularly its soluble form, influences astrocyte metabolism in the brain. Klotho is better known as an anti‑aging factor, but here they focus on its activity‑dependent release from neurons and its paracrine effects on nearby astrocytes.
Neuronal activity increases expression/release of Klotho, which then acts on astrocytes.Soluble Klotho drives astrocytic aerobic glycolysis (Warburg‑like shift) by interfering with pyruvate entry into mitochondria.Functionally, this enhances lactate production from astrocytes
Based on search results, Klotho—particularly soluble
-Klotho—influences cellular metabolism by modulating how cells process pyruvate, often acting to shift metabolism away from mitochondrial oxidation towards glycolysis and lactate production in specific cell types.
Effects on Pyruvate Metabolism
Hindering Mitochondrial Metabolism: In astrocytes, soluble Klotho has been shown to hinder the metabolism of pyruvate through the mitochondria.
Stimulating Lactate Production: Klotho stimulates the processing of pyruvate by lactate dehydrogenase (LDH), promoting aerobic glycolysis and increasing lactate formation/release.Neurons release soluble Klotho during activity, which shifts astrocytes toward aerobic glycolysis by blocking pyruvate entry into mitochondria. This enhances lactate production
This does not seem favorable
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@user73636 thanks for bringing this study to our attention. I don't really have any input here. It just is so complicated, isn't it? I guess there's really no such thing as a gene that just magically makes us live longer and healthier, right?
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But astrocytes are known to be basically glycolytic, so klotho seems to me to be just reinforcing their mode of operation.
Glycolysis is bad when it shouldn't happen there, but sometimes it's a better option than OXPHOS, even if it's inefficient.
Just imagine how quickly oxygen would be depleted if the brain chose to do OXPHOS predominantly with fatty acids, as is the case with the heart, or how much superoxide would be generated...
