I invented a drug combination to significantly increase free testosterone without any side effects.
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I took Avodart for about 10 years. It had some interesting effects some of which I miss, some of which I really don't. Not sure it's something I would want to play around with again.
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this is honestly one of the stupidest most retarded things I have read in a long time, some perverse wet dream of a skinny neurotic reddit-user wannabe pharmaceutical marketing and drug repurposing/patent-seeking psychopath adjacent. I would ask you to post your physiognomy but I believe we would be terrified to see the visage of someone who could come up with something so perverse and weird. a true manifestation of the ahrimanic spirit. I legitimately have to log off here for a week and think about how to detox my aura from what I just read.
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@sunsunsun I agree.
The large reason of why 5 a inhibitors are harmful is because they decrease neurosteroids. None of Proviron's metabolites have proven to be neurosteroids. So this is a BS combination.
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@alfredoolivas Effects of therapeutic doses of dutasteride on neurosteroids aren't clear, because of it's low ability to pass BBB. Some studies suggest it may increase neurosteroids in the brain, including allopregnanolone by decreasing conversion of progesterone into it in the peripheral circulation.
Is Dutasteride a Therapeutic Alternative for Amyotrophic Lateral Sclerosis?
https://www.mdpi.com/2227-9059/10/9/2084/pdf?version=1661512755
Data exists regarding other mechanisms of neuroprotection by dutasteride, such as protection of dopaminergic neurons.
LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent
https://www.mdpi.com/2076-3425/11/11/1411
Peripheral Neuroprotective and Immunomodulatory Effects of 5α-Reductase Inhibitors in Parkinson’s Disease Models
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.898067/full
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@LunaticRed Yes but Neurosteroids cross the BBB. Peripheral reduction will decrease Brain levels. If you reduce progesterone's metabolism, that won't mean substantially more gets into the brain. The brain can't do all the converison.
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@alfredoolivas
In this study, only doses of 2.5mg of dutasteride (which is far more than needed to suppress 90% of DHT) showed significant reduction in serum allopregnenalone, which actually resulted in positive cognitive effects.5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder
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@LunaticRed said in I invented a drug combination to significantly increase free testosterone without any side effects.:
In this study, only doses of 2.5mg of dutasteride (which is far more than needed to suppress 90% of DHT) showed significant reduction in serum allopregnenalone, which actually resulted in positive cognitive effects.
Of course, inhibiting inhibtory hormones like allopregnenolone would increase coginiton. If you inhibit adenosine (an inhibitory molecule) via caffeine you too get increased cognition. That doesn't mean it is good for you.
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@alfredoolivas Depends on your goals.
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@LunaticRed That is true, but a totally different topic. There are much more tested methods to improve coginition via "unhealthy" pathways, such as modafinil and viagra.
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@LunaticRed
What exactly would those goals be?I'm lost on why one would want to increase free test, but have a significant portion of that not convert to DHT.
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@sphagnum So that you can have all the benefits caused by testosterone (anabolism. energy) and none of negatives associated with DHT (benign prostatic hyperplasia, male pattern baldness, cardiac remodeling and fibrosis). The only benefit of DHT is aromatase inhibition, but you will inhibit aromatase by proviron using this combination.
