I invented a drug combination to significantly increase free testosterone without any side effects.
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You need 2 drugs for this - dutasteride and proviron. It's quite an elegant combination, because it bypasses all downsides of just using testosterone - conversion of testosterone to DHT and estrogen, need in pinning, and shutdown of HPTA.
Dutasteride is 5-alpha reductase inhibitor, it blocks conversion of testosterone to DHT (paracrine hormone responsible for benign prostatic hyperplasia, androgenic alopecia, and heart hypertrophy) and can lower serum DHT by up to 95%. It also increases testosterone by 20-30%. However, increase in free testosterone is noticeable only first few months, because after prolonged treatment much of it becomes bound testosterone, meaning it's bonded to sex-hormone-binding globulin and albumin and cannot be effectively used by your body.
This increase in testosterone leads to increased estrogen due to aromatization, and it's what actually causes dutasteride's side effects like erectile disfunction and gyno in some people, and why most side effects usually subside after some time.
Proviron is DHT derivative that has highest binding affinity to SHBG of all AAS, far greater than T, and effectively displaces it from SHBG, raising free T. It has significant anti-estrogenic action, possibly due to aromatase inhibition and antagonism of estrogen receptors, and this results in conversion of large proportion of free T to DHT, which causes proviron's side effects.Combination of this drugs will results in increase of total testosterone from dutasteride, which is then will be made free due to displacement from SHBG by proviron, and will not convert to either DHT or E, completely negating side effects of both drugs.
Dosages shall be calculated according to individual measurement of hormones (DHT, SHBG, T, E). 0.2mg of Dutasteride decreases 80% of serum DHT, with doses equating to 6mg in humans causing negative changes in penile morphology in rats. Dutasteride needs time to reach steady state, so if you want to immediately introduce proviron you would need to start with high doses and then decrease them. You can calculate optimal dosing protocol using this software: https://github.com/FuzzyCat444/Dutasteride-Pharmacokinetics-Pharmacodynamics/releases/tag/v1
Proviron dosages shall be in 6-25mg range, in large doses it starts to suppress HPTA and decrease natural testosterone production, possibly because large fraction of it becomes free instead of bound to SHBG and acts systemically. -
I took Avodart for about 10 years. It had some interesting effects some of which I miss, some of which I really don't. Not sure it's something I would want to play around with again.
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this is honestly one of the stupidest most retarded things I have read in a long time, some perverse wet dream of a skinny neurotic reddit-user wannabe pharmaceutical marketing and drug repurposing/patent-seeking psychopath adjacent. I would ask you to post your physiognomy but I believe we would be terrified to see the visage of someone who could come up with something so perverse and weird. a true manifestation of the ahrimanic spirit. I legitimately have to log off here for a week and think about how to detox my aura from what I just read.
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@sunsunsun I agree.
The large reason of why 5 a inhibitors are harmful is because they decrease neurosteroids. None of Proviron's metabolites have proven to be neurosteroids. So this is a BS combination.
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@alfredoolivas Effects of therapeutic doses of dutasteride on neurosteroids aren't clear, because of it's low ability to pass BBB. Some studies suggest it may increase neurosteroids in the brain, including allopregnanolone by decreasing conversion of progesterone into it in the peripheral circulation.
Is Dutasteride a Therapeutic Alternative for Amyotrophic Lateral Sclerosis?
https://www.mdpi.com/2227-9059/10/9/2084/pdf?version=1661512755
Data exists regarding other mechanisms of neuroprotection by dutasteride, such as protection of dopaminergic neurons.
LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent
https://www.mdpi.com/2076-3425/11/11/1411
Peripheral Neuroprotective and Immunomodulatory Effects of 5α-Reductase Inhibitors in Parkinson’s Disease Models
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.898067/full
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@LunaticRed Yes but Neurosteroids cross the BBB. Peripheral reduction will decrease Brain levels. If you reduce progesterone's metabolism, that won't mean substantially more gets into the brain. The brain can't do all the converison.
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@alfredoolivas
In this study, only doses of 2.5mg of dutasteride (which is far more than needed to suppress 90% of DHT) showed significant reduction in serum allopregnenalone, which actually resulted in positive cognitive effects.5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder
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@LunaticRed said in I invented a drug combination to significantly increase free testosterone without any side effects.:
In this study, only doses of 2.5mg of dutasteride (which is far more than needed to suppress 90% of DHT) showed significant reduction in serum allopregnenalone, which actually resulted in positive cognitive effects.
Of course, inhibiting inhibtory hormones like allopregnenolone would increase coginiton. If you inhibit adenosine (an inhibitory molecule) via caffeine you too get increased cognition. That doesn't mean it is good for you.
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@alfredoolivas Depends on your goals.
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@LunaticRed That is true, but a totally different topic. There are much more tested methods to improve coginition via "unhealthy" pathways, such as modafinil and viagra.
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@LunaticRed
What exactly would those goals be?I'm lost on why one would want to increase free test, but have a significant portion of that not convert to DHT.
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@sphagnum So that you can have all the benefits caused by testosterone (anabolism. energy) and none of negatives associated with DHT (benign prostatic hyperplasia, male pattern baldness, cardiac remodeling and fibrosis). The only benefit of DHT is aromatase inhibition, but you will inhibit aromatase by proviron using this combination.
