Dietary calcium does not affect pyruvate dehydrogenase?
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2 different AI models seem to agree?
Your body maintains a very strict range of calcium in your blood regardless of how much you eat. Because of this:
Homeostasis: If you eat more calcium, your body simply absorbs less or excretes more rather than letting it flood your cells.
Supplementation: Studies on calcium pyruvate supplements have shown they do not significantly affect PDH activity or exercise performance in humans.
Intracellular Control: PDH is located deep inside the mitochondria. Its activity is triggered by local calcium shifts (like those caused by muscle contraction or insulin) rather than the total amount of calcium in your diet.The only way calcium "affects" PDH is at the cellular level, not the dietary level:
Mitochondrial Activation: Inside the cell, calcium ions (
) activate the PDH phosphatase enzyme. This removes a phosphate group from PDH, switching the enzyme "on" so it can convert pyruvate into energy.
Energy Demand: This process is vital during exercise. When your muscles contract, calcium is released internally, which immediately signals PDH to ramp up energy production. -
@user73636 said in Dietary calcium does not affect pyruvate dehydrogenase?:
Your body maintains a very strict range of calcium in your blood regardless of how much you eat. Because of this:
The quesiton is how does PTH (affected by dietary calcium) affect PDH.
