@djoats Its not a good long term solution, but in a pinch NSAIDs enhance the effects of anti-diuretic hormone, helping to retain water. Theyre commonly used for bedwetters and diabetes insipidus

TLDR: I go into some sort of hypothermic panic, perhaps hypovolemic shock when eating pomegranate or grapefruit

Hello, Ive been trying to fix my longstanding hyperactive adrenals. Symptoms and tests:

• Pregnenolone: high (460, normal 23-237)
• DHEA: high
• cortisol: normal (both instant & 24hr) but on higher end of range
• DHT: high (excessive body hair)
• aldosterone: low
• testosterone: on lower end (450)
• estrogen: normal
• anion gap: low
• bicarbonate: high
• excessive thirst & urination that gets worse at night. I can't quench my thirst no matter how much I drink, and I just piss it right out.
• HBP 135/85 since I was 6
• easily gain muscle mass but also easily gain fat
• very shallow sleep
• early puberty at 6
• feel fatigued and generally unwell 24/7
• bloodwork usually looks like im severely dehydrated, I.E. high RBC, high WBC, high albumin

I started noticing symptoms at 12-13 and its gone downhill since then.

When Im under extreme stress, I feel amazing and most of my symptoms go away, I also lose weight. However this is not a good long term solution. Caffiene and creatine also slightly help. Ibuprofen helps alot, I am able to retain water and sleep with it.

I did an experiment with 12oz of grapefruit juice every morning:
1st day: I felt pretty good actually
2nd day: woke up with a faint heartbeat
3rd day: Woke up feeling weird with very faint heartbeat. My BP was low at 110/70 (normal 135/85). I soon began to have the worst panic attack of my life, almost like shock, and was shivering my ass off, checked my temp was 95f. I was excessively urinating about every 15 minutes, and felt worse when I drank water. My stomach severely bloated as well. This episode subsided after 2 hours, I felt ok and my temp went back up to 98f.

During nighttime I felt awful and had similar symptoms. I ended up having to wait for the sun to break to fall asleep, that or sleep with my lights on to trick my circadian rhythm. These symptoms waned over a period of 2 weeks.

I have very similar symptoms when I eat pomegranate, but its alot less bad.

Anyone know the overlapping hormonal effects of pomegranate and grapefruit that could cause this? I think its pivotal to my health issue, thanks. My current theory is either a hormone "blockage" or screwed up cortisol metabolism, as stress seems to brute force through it.

p.s. I do not take any meds at all, so a drug reaction couldnt have caused this. I also have tried anxiety meds in the past. The first time I take them Ill feel really good, but after a week of taking them I feel like i just drank 10 bangs and have severe insomnia, so I dont think this is psychological.