The pro-metabolic drug DNP, banned by FDA, may treat most diseases
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The duplicity of public health agencies (and mainstream media) knows no bounds. The chemical 2,4-dinitrophenol (DNP) is one of the oldest (and most successful) weight loss drugs. It works by not only increasing respiration but also by uncoupling the reactions in the electron transport chain from ATP generation, so that a higher proportion of the energy we get from food is released as heat. In other words, DNP drastically increases thermogenesis (and metabolic rate/speed), which allows a significant portion of food to be “wasted” as heat instead of stored in the body (mostly as fat). Thus, DNP can not only prevent the weight gain from an obesogenic diet, but also induce weight loss in an already obese person. These effects made DNP a very popular remedy for weight loss in the first half of the 20th century. However, due to a few deaths as a result of heat strokes caused by overdosing DNP, the FDA stepped in and banned the sales and personal use of DNP in the US. To this day, people get aggressively prosecuted if they attempt to sell DNP online or give it to friends/family. Interestingly, the FDA does not seem to be as strict when it comes to pharma companies toying with such “poison”. Despite the ongoing fearmongering that DNP is “deadly”, behind the scenes multiple pharma companies are running clinical trials with DNP for quite a few serious and truly deadly conditions. In order to limit the fallout with the public due to the double-standard, DNP is no longer called DNP in clinical trials since it has now been patented (another abomination, as generic compounds should be unpatentable), as the pro-mitochondrial drug MP-101 (and its close analog MP-201). A quick look at the list of trials with MP-101 shows that pharma companies are banking on MP-101 treating a wide variety of serious chronic issues including multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Huntington Diasease (HD), Alzheimer Disease (AD), mental illness, obesity, diabetes, immunodeficiency, congenital disorders, etc (see first two links below). In other words, pretty much all major chronic conditions known to medicine. I guess the good news in this entire charade is that if FDA and pharma companies believe DNP….errr..I mean MP-101….can treat all of these conditions then this is an open admission by those entities that all such diseases are metabolic in origin, since DNP…errr…I mean MP-101…has no known mechanism of action other than its uncoupling/pro-metabolic effects. The bad news is that perhaps millions of people worldwide will get poisoned by the newest pharma fad for weight loss known as GLP-1 agonists (Ozempic, anyone?) before the public wisens up to the fact that there are safer, and truly beneficial pharmacological alternative (e.g. uncouplers) for losing weight. Now, since DNP usage does have risks due to its potency as a thermogenic compound, and it is highly illegal to use therapeutically (unless you are a pharma company, rubbing shoulders with the FDA), one could approximate its effects with other uncouplers such as aspirin, caffeine, progesterone, salt, flavones/flavanones, etc.
https://adisinsight.springer.com/drugs/800050437
https://synapse.patsnap.com/drug/7efa6f9581334bb3b18623859ad7835d
EU agency OKs study of therapy to improve mitochondrial function
“…Mitochon Pharmaceuticals is launching a pilot clinical trial to evaluate MP101, its treatment candidate for improving mitochondrial function, in people with multiple sclerosis (MS) and other neurodegenerative diseases. The announcement follows the trial’s clearance by the European Medicines Agency (EMA), which enables Mitochon to begin enrolling patients with neurodegenerative conditions in the biomarker study. The Phase 1/2a trial will enroll people with MS, amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, and Huntington’s disease, each of whom will receive the experimental therapy for 14 days. The goal is to demonstrate whether the therapy is safe in these populations and induces relevant changes in disease-related biomarkers. “We are delighted for the opportunity to explore [the] provocative idea that most, if not all neurodegenerative diseases are rooted in mitochondrial dysfunction,” John G. Geisler, PhD, Mitochon’s co-founder and chief scientific officer, said in a company press release.”
“…Mitochondria are small cellular structures that produce most of the energy cells need to function — including the energy required for nerve cells to transmit electrical signals to other cells. They’re also involved in other essential cell functions. However, research has shown that these cellular organelles are dysfunctional, or don’t work properly, in most neurodegenerative conditions, including in multiple sclerosis. Thus, impaired mitochondrial function is thought to play an important role in neuronal damage and disease progression. MP101 is an investigational, brain-penetrant oral therapy that works as a mitochondrial stimulator, improving the function of these organelles across cells in the brain and spinal cord. This increases the amount of energy produced by cells and also induces the production of neuroprotective factors, which help protect cells from neurodegenerative disease processes.”
“…In preclinical studies, researchers showed that MP101 was able to protect nerve cells from the demyelination that occurs in people with MS. It also reduced disease severity and improved mobility in animal models of the disease. Similar results were obtained with MP201, a similar candidate molecule. The upcoming trial is expected to confirm the benefits of MP101 in neurodegenerative conditions. If positive, these findings are expected to support Phase 2b studies in people with primary progressive MS and secondary progressive MS, as well as ALS, Huntington’s, and Alzheimer’s. “We predict that chronic treatment with this unique platform, at micro-doses, will resolve mitochondrial issues and change important disease specific biomarkers in all four indications similarly,” Geisler said.”
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@haidut Many thanks for all the good info you share with us. One thing that is particularly helpful with these (beneficial) drug studies is how, in the case of expensive and/or prescription drugs, you provide other easily available options. No one else in the health and wellness blogosphere provides this valuable information. I also love that you explain what the studies mean which saves me a lot of time. Hope you're able to keep providing such a valuable service, as well as supplements which are of the highest quality available anywhere.
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@haidut I second S. Holmes sentiments.
Since all such diseases are metabolic in origin, then widespread "MP101" use is likely to increase the population's intelligence.
They aren't scared of an intelligent populace?? -
lost 20 pounds this month running a relatively low dose of DNP and just walking as often as possible in the woods near my house. diet is like 500carbs 200p 130f. supplementing with k2 d3 and progesterone. never felt too hot or out of breath. a fan is helpful for sleeping though. ray peat said cataracts (which to my knowledge is a relatively rare side effect in men) can be alleviated by increasing vitamin C intake. also peripheral neuropathy is a side but ive never gotten it, other than that theres basically no actual side effects other than heat. its fucking awesome.
breakfast for dinner enjoyer
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@Chud said in The pro-metabolic drug DNP, banned by FDA, may treat most diseases:
lost 20 pounds this month running a relatively low dose of DNP and just walking as often as possible in the woods near my house. diet is like 500carbs 200p 130f. supplementing with k2 d3 and progesterone. never felt too hot or out of breath. a fan is helpful for sleeping though. ray peat said cataracts (which to my knowledge are a relatively rare side effect in men) can be alleviated by increasing vitamin C intake. also peripheral neuropathy is a side but ive never gotten it, other than that theres basically no actual side effects other than heat. its fucking awesome.
Do you have a reference for this? Thanks
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@Peatly
yeah sure it was posted to the email exchange thread on RPF https://expulsia.com/health/emailexchanges#DNP -
Any good sources of DNP?
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@Chud Thanks
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@Chud Can you tell us what dose you ran?
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@Chud Did you increase calories when using it?
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@Chud said in The pro-metabolic drug DNP, banned by FDA, may treat most diseases:
lost 20 pounds this month running a relatively low dose of DNP and just walking as often as possible in the woods near my house. diet is like 500carbs 200p 130f. supplementing with k2 d3 and progesterone. never felt too hot or out of breath. a fan is helpful for sleeping though. ray peat said cataracts (which to my knowledge is a relatively rare side effect in men) can be alleviated by increasing vitamin C intake. also peripheral neuropathy is a side but ive never gotten it, other than that theres basically no actual side effects other than heat. its fucking awesome.
Any suggestions (links?) on dosage?
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Have you seen this? Disappointing, but not surprising. https://www.healio.com/news/primary-care/20241010/most-peer-reviewers-for-major-medical-journals-receive-industry-payments
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@Regina Taking Vitamin E is also super important during DNP usage. To protect from the added FFA
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In the bodybuiling comunity its well known to be really damaging to metabolism. It can make you skinny fat really easy, hunge weight loss but also huge loss of tissue.
But i wonder if its because its used in high dose. Saw some post few years back about microdosing it, and how it could help brain health
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@Lordallmighty alot of stuff in the bodybuilding “community” is idiotic
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in the bodybuiling comunity its well known to be really damaging to metabolism. It can make you skinny fat really easy, hunge weight loss but also huge loss of tissue.
If anyone says this they have no idea what they're talking about and clearly never bothered to read any of the early or even recent literature and studies on DNP, Tainter's most notably, almost all of which is available on pubmed. They all think themselves clever and somehow contributing to the discourse by repeating the meme that it's a pesticide and "burns you from the inside out."
In the therapeutic and even higher dosages it has shown to be remarkably if not almost completely muscle sparing. Far more so than even thyroid hormone. It is a fat-burning drug.
There are plenty of reasons to avoid DNP but "damaging to metabolism" is not one of them.
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Where do ppl buy it from?
