Effect of Aspirin on Male Hormones, Testicular and Epididymal Histology In Mice
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https://nahrainuniv.edu.iq/sites/default/files/Binder1_6.pdf
I'm still fairly new to the ideas expressed here in this forum. I found this study about aspirin in male mice and figured that it warrants discussion. Looking forward to hearing your thoughts on this.
"Conclusions" (copied verbatim) From the results of the present study the following conclusions have been arrived at:
- A significant decrease (P < 0.05) in body weight in experimental group 2 (with experimental group 1 and with control).
- Aspirin administration concerning its effect on the male reproductive system caused a highly significant decrease in testicular and epididymal weight.
- Aspirin administration also caused a significant decrease in seminiferous tubules diameter associated with increase in empty spaces between them and thickness of semeniferous tubules. A similar decrease in epidydimal tubular diameter and height of their cells.
- A significant decrease in serum LH, FSH and testosterone level in both experimental groups.
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@sexpresso69 Not really sure. I didn't read the whole thing, it's 88 pages. First thing I like to do with mice studies is finding out what the HED of the dosages are, just to make sure they're not taking some insanely large dose. If I did the conversion right I don't think either 5mg/kg or 25mg/kg is that large. Maybe someone else can elaborate on it.
There was a study done in humans showing athletes increased their T on aspirin. I also recall a randomized controlled trial done in women, showing the aspirin group had statistically significant reductions in estradiol compared to the placebo. So perhaps in the grand scheme of things a mice study doesn't mean much.
Regardless my personal opinion is not to rely on aspirin as a aromatase inhibitor or T booster. 80-325mgs daily would be good for general anti-cancer protection. Those are safe dosages that can be done indefinitely. The really high dosages are for people who already have diagnosed cancer.
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@Mulloch94 25mg/kg body weight would be 0.75 mg aspirin for a typical lab male mouse. The equivalent for a 90kg human male would be 2.25 grams of aspirin. I will try to find that study, thank you for your reply!
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@sexpresso69 Oh wow, that is kinda high. I royally fucked up how I was converting that then. For some reason I got like 140mgs lmao.
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@Mulloch94 I also see that they injected it into the mice, rather than how we take it through our digestive system. And yea the dosages were give twice per day. If you're around 80kg then those doses would be like 800mg per day or 4000mg per day. Interestingly the 800mg per day had 3x as much testosteroone as the control, but the 4000mg HED had 3x lower than the control.
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@dan-saintdominic That's interesting. 800mgs was the "sweet spot" dose that raised T in the human athletes I was thinking of here. It seems like aspirin's effects on steroids is definitely a U shaped curve. With dosages right under 1 gram being the best.
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A detailed review of Aspirin's positive sides https://testonation.com/2023/05/22/aspirin-on-testosterone-dopamine-and-sexual-function/
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@Mulloch94 Good to know. I've been taking 2-3 grams every day for about a week with no side effects and feel great. But I am going to scale down to 800-1000mg unless I am sick or have a headache. Thank you
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Can we discuss this further please? Here’s another study which shows that aspirin’s inhibition of prostaglandin synthesis inhibition “ablates” Sertoli cells, seminiferous tubules, AND Leydig cells through arteriole constriction and ischemia, causing “degenerative and retrogressive effects on the testes…”
Scary stuff
Ablate
- remove (body tissue) surgically.
- gradually remove material from or erode (a surface or object) by melting, evaporation, frictional action, etc., or erode (material) in this way.
I’m starting to wonder whether the estrogen-lowering effects of aspirin might be due mostly to inhibition of the synthesis of the substrate of estradiol, namely, testosterone…
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@vocedilegno said in Effect of Aspirin on Male Hormones, Testicular and Epididymal Histology In Mice:
I’m starting to wonder whether the estrogen-lowering effects of aspirin might be due mostly to inhibition of the synthesis of the substrate of estradiol, namely, testosterone…
Some time ago Haidut raised his testosterone to above 150% of the norm with Aspirin, so it's hard to believe in the T inhibition hypothesis...
A screenshot from another forum, I won't link to RPF, because of Charlie's crazy copyright restriction...
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The estrogen lowering effect of aspirin is related to it's inhibition of aromatase via COX-2 interactions, not testosterone. There's been RCTs in women with aspirin on estradiol. So we can be fairly certain this is the case.
The amount of sheer data we have available on it's effects of testosterone is limited at best. Even if you include the in-vitro and animal studies, which I don't. I think once human research begins to accumulate the animal and cell culture stuff can be taken with a grain of salt.
All the limited human interventions thus far has shown an increase in T when provided at the right dosages. But we're going to be stuck exactly here until (or if) anyone decides to fund a comprehensive randomized double blind placebo control.
Which is unlikely. That's expensive and the medical establishment has no interest in proving such things, it only serves to hurt them. They're already afraid of aspirin's anti-cancer effects. They didn't like the Harvard "wonder drug" article back in like 2014.
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@Kvirion said in Effect of Aspirin on Male Hormones, Testicular and Epididymal Histology In Mice:
A screenshot from another forum, I won't link to RPF, because of Charlie's crazy copyright restriction...
Hey bro, we should get a coalition together an start archiving all RPF threads that link to scientific studies over on https://archive.org/. There's a lot of good stuff in there I don't want to ever forget, and you know how fascists get, he'll start deleting threads or removing useful information.
At the very least we should back up all of Haidut's threads. Then slowly start getting all the others.
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@Mulloch94 Yes, I think someone has already done a backup/download. I saw such news here or on Twitter.
This https://bioenergetic.forum/post/8643Moreover, as far as I know, Haidut also backed up his threads.
BTW I have my archive/ doc file with useful links from RPF, but not sure how to use https://archive.org/.
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@Kvirion Wow thanks, I didn't know that existed already. As Charlie would say...doing god's work!
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I was looking into this topic as well and found this study
https://medcraveonline.com/PPIJ/aspirin-affect-on-reproduction-of-male-rat-an-overview.html
Summary :
Reproductive health : Aspirin significantly decreases sperm production , motility and increases the number of abnormal sperm cells. Decreases the weight of the testes , Lowers testosterone levels ( Due to its inhibition of prostaglandins and disruption of androgen synthesis). And it impairs the later stages of spermatogenesis.
Testes structure , it causes cytological and nuclear degenerative changes.Decreases the amount of leukocytes in the blood , indicating a compromised immune system. Decreases in cell volume and hemoglobin levels , indicating potential anemia and reduced oxygen carrying capacity of the blood.
However this is from Guangdong Ocean University , it ranked 209th in China and 1524th in the world for biology and it is overall ranked #662 in the world.
The study gave no measurements or data to analyse , not reliable
This study has 0 citations , meaning that it is not a very valued source of information -
@sexpresso69 Watch out because Asprim lowers Ferritin/ Iron stores if taken regularly, some even get Anemia from too much. It’s a good toolkit to have in your arsenal, but no reason to take it daily.
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@GreekDemiGod
So take iron supplements or consume more iron to counteract this? -
@b1 said in Effect of Aspirin on Male Hormones, Testicular and Epididymal Histology In Mice:
@GreekDemiGod
So take iron supplements or consume more iron to counteract this?I personally wouldn't. Iron supplements are dangerous, and it can be a potent oxidizer. Almost as bad as PUFA.
Unless you've got cancer, there's never really a reason to take more than 1,000mg a day. Even less in most cases will work. 500mg is enough to lower stress and free fatty acids.
