Reversing Non-Alcoholic Peaty Liver Disease

[HubblyBubbly]

I have a lad in my DMs describing a set of symptoms that he can’t seem to shake no matter what.

Long story short, the only thing that I can guess is that his liver is fatty from all the sugar he’s been memed into consuming. He’ll take a liver enzyme test, but given that it’s positive, what is the treatment plan here?

Will you have to trade a ‘pro-metabolic diet’ to unburden the liver? Cut sugar and fat probably. Anything that spikes insulin. Lots of low impact exercise. Glycine? Milk Thistle?

Any Peaty silver bullets?

[Big_El]

@HubblyBubbly

• Decrease Fat intake
• Use Carrot Salad/Psyllium/Charcoal regularly throughout the day to bind bile and excrete it
• useful supplements: TUDCA, Lactoferrin, Taurine, Glycine, DeFibron, Vitamin K2 MK4, Vitamin D, Vitamin E, B-Vitamins (Energin), Phophatidylcholine (MitoLipin), Aspirin, Niacinamide
• Hot baths with Magnesium Chloride and Baking Soda

[HubblyBubbly]

@Big_El Solid yes. What do you reckon carb intake should look like? Minimal I’m guessing? Any preference for complex vs simple?

[Fructose]

@HubblyBubbly does he have insulin resistance?

[Big_El]

@HubblyBubbly
I personally do not think that carbs should be restricted. However I would make sure to space the intake out throughout the day, so more frequent smaller meals rather than fewer bigger meals. I think combining starch, sugar and a little fiber in every meal is the best approach.

[HubblyBubbly]

@Fructose one of his symptoms is dizziness after lifting weights — despite drinking a Red Bull before and eating enough etc. So insulin resistance might be implicated, or possibly low blood volume.

[HubblyBubbly]

@Big_El Very interesting. He said he doesn’t eat any starch to avoid the insulin spikes.

I understand incorporating fiber and sugar, but keeping starch in the diet with fatty liver is new — could it be that the insulin spike liberating fatty acids from the liver is a way to lower its fattiness?

[Big_El]

@HubblyBubbly
I don’t think the starch will lead to an insulin spike when combined with sugar, fiber and protein. I see starch as a sort of „fiber light“ which can probably bind to and help eliminate some additional bile.

[TexugoDoMel]

Choline deficiency alone can cause fatty liver, so it's important to maintain an adequate intake of choline and methionine.

Chris Masterjohn has a post commenting on it: "Fatty Liver: Why Choline Matters More Than Sugar, Alcohol, or Fat"

"Neither fat nor sugar nor booze are the master criminals here.

Rather, these mischeivous dudes are just the lackeys of the head honcho, choline deficiency. That's right, folks, it's the disappearance of liver and egg yolks from the American diet that takes most of the blame.

Dietary fat, whether saturated or unsaturated, and anything that the liver likes to turn into fat, like fructose and ethanol, will promote the accumulation of fat as long as we don't get enough choline. Once that fat accumulates, the critical factor igniting an inflammatory fire to this fat is the consumption of too much PUFA (seed oils)."

[HubblyBubbly]

@TexugoDoMel Did not know this definitely looking into the choline connection.

[TexugoDoMel]

@HubblyBubbly If I'm not mistaken, a deficiency of choline (phosphatidylcholine) hinders the production of VLDL, so triglycerides accumulate in the liver.

link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1394528/?page=1

[GreekDemiGod]

@HubblyBubbly First, I’d make sure to have a liver ultrasound to confirm a fatty liver.