Cholesterol, Thyroid and Mortality
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Cholesterol is the precursor to the "youth" hormones such as Progesterone and DHEA, and thyroid is necessary for their synthesis. Hypothyroid people tend to also have a higher cholesterol level. Why is it then that AC-mortality and cholesterol have a U shape relationship? Wouldn't people with a well-functioning thyroid convert cholesterol to the youth hormones and have lower levels, but a better life expectancy as a consequence?
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@FTMarinetti too high = sign of hypothyroid and all the problems that comes with that, too low = immunity & myelin/brain function problems , more people in this group also on statins artificially lowering cholesterol and likely a bunch of other medications that worsen health / or are in worse health in general indicated by being on the medication
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@cs3000 Thank you for the response. In that study high (200-240) cholesterol was associated with lower all-cause mortality. I don't know how much statins lower cholesterol, but I'd assume that people in the 100-200 range aren't on statins. At the same time people at the 240 range should have less protective hormones as they're hypo.
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@FTMarinetti they can lower it a lot like -30% -40% i think, and considering how often theyre thrown at people and with the perspective of "cholesterol = bad" would assume a lot of that group are kept on them to ensure its kept low and away from "high" cholesterol what they see as "healthier", eg in uk for a healthy person they see <200 as good and for an at risk person 150. ironically they see the cutoff point for dropping below good levels by that study as a ceiling level, inverse. i know someone who got prescribed statins with only a mild elevation and no heart problems
then for the people that arent on more medications in that group indicated by the lower cholesterol, whatever other reason is causing their low cholesterol inducing poorer health (e.g cholesterol lowered in sepsis https://pubmed.ncbi.nlm.nih.gov/3940695/)for the other side maybe cholesterol as a protective molecule makes up for some of the effects of lack of thyroid to a point? (e.g preventing cancer and death by infections) , but over that the thyroid / hormones might get too low regardless
