Inhibition of serotonin biosynthesis suppresses tumor growth in vivo

[Mauritio]

" TPH1 is highly expressed in SBNETs and many cancer types. TPH1 knockdown cells and telotristat treated cells showed similar growth rates as control cells in vitro . However, TPH1 knockdown cells formed smaller tumors in vivo and tumors were less vascularized. Although Tph1 inhibition with telotristat showed no effect on tumor cell growth in vitro , Tph1 inhibition reduced tumor formation in vivo . Serotonin inhibition in combination with other therapies is a promising new avenue for targeting metabolic vulnerabilities in NENs."

• https://pubmed.ncbi.nlm.nih.gov/37066322/

[Regina]

@Mauritio Nice find! Thank you.