Sleep apnea cured in 2 months with either progesterone or thyroid (study)
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Here's an intervention study showing progesterone or thyroid hormone at different tests work to fix sleep apnea when hypothyroid is present
https://pubmed.ncbi.nlm.nih.gov/6792957/
(they used a synthetic progestogen which binds more receptors like androgen receptor or cortisol receptor, but progesterone has been shown useful for sleep apnea so effects mediated at least greatly by its progesterone receptor action)
They used T4 for the thyroid hormone.4 weeks of the progestin and almost all symptoms gone or 2 months of thyroid all symptoms gone completely fixed, with a placebo period in between
Medroxyprogesterone acetate (MPA) therapy for 4 wk caused a reduction in awake PaCO2 (38 to 33 mm Hg), and an increase in VE/VCO2 (17%), mouth occlusion pressure (50%), and AVE/VCO2 (23%). During sleep, apneas were completely eliminated and only one episode of oxygen desaturation occurred.
L-thyroxine therapy for 2 months after a placebo period caused an awake isocapnic hyperpnea with no change in PaCO2 and VE/VCO2 despite a 23% increase in VE. Mouth occlusion pressure increased 37% but delta VE/delta VCO2 was unchanged. Obstructive apnea and oxygen desaturation during sleep were completely eliminated with L-thyroxine.
The patient noted completed relief of symptoms with both MPA and L-thyroxine. We concluded that the sleep apnea syndrome was the presenting manifestation of hypothyroidism in this patient and was solely responsible for his symptoms and disability. -
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