StressNon dose/route of administration?
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Hi Guys, I'm also moving from the ex RPF
There is an extensive thread over there about the Idea Labs Pregnenolone. However, the more I read, and the more I listen to Georgi videos with Mercola on the topic, the more I scratch my head on dosing, and route of administration.
On the thread @haidut mentions that the ideal dose of Pregnenolone is 30/50mg, or below 100mg, considered as a oral powdered form.
Using StressNon topically, when Preg was dissolved in DMSO, FEMA or Eugenol, 100mg oral Preg = to 10mg of StressNon, However, since the change in the SFA/anhydrol there was not any more comments on the bioavailability of the product, can anyone confirm is the same?
Oral route: I head Georgi and Mercola talking about dissolving Pregnenolone and DHEA in long chain FA so that it will by pass first pass metabolism when ingested. If this is true, then I would expect to use same dosing as topical, such as 3/5mg to get the ideal dose of Preg. Does that make sense? is anyone using it orally?
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@GRay I have a lot of notes about pregnenolone from RPF, but the most relevant to your question would be the following, which confirms the 10:1 effectiveness of topical to oral, as well as giving more detail on the oral route. If I remember correctly, this quote is from Haidut:
"Usually 10mg or below should be sedating. In one human study 1mg improved sleep a LOT and it would not have done so if it was stimulating. But it really depends on the hormonal state of each person. It has not been tested on too many people but I have tested on myself. Taking the full 20mg dose StressNon topically in one sitting results in about the same pregnenolone concentration as an oral dose of about 200mg pregnenolone. The blood tests were done 1 and 8 hours post administration. Oral StressNon is similar to oral pregnenolone, so no advantage in taking it orally. But topically, StressNon seems to have about 10:1 effectiveness in raising blood pregnenolone levels. Both oral and topical pregnenolone will undergo a heavy conversion into other steroids. Both liver and skin are very active steroidogenic organs. But the liver likes to accumulate pregnenolone (as does the brain) so if you ingest even a hefty dose, very little of it will end up in the bloodstream as unchanged pregnenolone. The liver will convert maybe 60% to other steroids, keep another 30%-35% for itself and only let about 1%-2% unchanged pregnenolone in the blood. Topical pregnenolone , while also undergoing conversion does not metabolize as extensively unless you apply to a really large skin area. So, topical pregnenolone will deliver more unchanged pregnenolone to the blood, especially when the carrier is DMSO."
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@Mossy thanks. Sorry the late response, as I was not notified about it.
I have read this before. However, it is a bit confusing with what Haidut says, as in the text you attached, he mentions that there is no advantage of taking oral stressNon, but then in a video interview with Dr Mercola, he mentions how pregnenolone dissolved in SFA will bypass first metabolism in the liver, that means a 5mg dose of Pregnenolone will be almost 100% bioavailable, so theoretically when it is taken orally, the rule 10:1 can still be applied in this case.
What is more confusing is that he mentions that a oral dose for full replacement is 30/50mg, and I assume orally with first pass metabolism, but with stressnon could probably be 3/5mg then.
However, when someone is very low on Pregnenolone, 100mg of oral micronized Preg, generally takes levels to mid range.
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@GRay No worries on the delay; as you see, I'm delayed myself.
It's hard for me to always follow these principles with proper understanding, but how are you concluding that the dissolved in SFA pregnenolone was oral and not topical and that it is now 10:1? By the fact that it will bypass first metabolism in the liver?
If I sound ignorant it's because I am. I try to glean what I can from all of my notes, but I end up getting lost through the twist and turns. For, as you're showing, we can hear one thing one day and something different another day. This is no knock on Haidut at all, or anyone else, I know these things are complicated, especially for those of us who have no background in biology, medicine, etc.
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@GRay pregnenolone dissolved in vitamin e isn't the same as taking pregnenolone powder by itself. if he is talking about taking 200mg orally he is probably talking about taking the raw powder.
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@Mossy said in StressNon dose/route of administration?:
t's hard for me to always follow these principles with proper understanding, but how are you concluding that the dissolved in SFA pregnenolone was oral and not topical and that it is now 10:1? By the fact that it will bypass first metabolism in the liver?
I found the 10:1 rule on the older forum, and it was in the topical route, but as it was mentioned in the video with Mercola and Haidut, Preg dissolved in long chain SFA will by pass first pass metabolism, same way it does when applied topically.
However, I have decided to try again a micronized pregnenolone orally, as I think it may be the best delivery method for Pregn. Even Peat was taking Pregnenolone this way
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@sneedful said in StressNon dose/route of administration?:
if he is talking about taking 200mg orally he is probably talking about taking the raw powder.
Yes, for sure
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@GRay said in StressNon dose/route of administration?:
However, I have decided to try again a micronized pregnenolone orally, as I think it may be the best delivery method for Pregn. Even Peat was taking Pregnenolone this way
Interesting. Please report back if you think there is anything worth sharing.
