New Method to Treat Hernias in Elderly Men with Progesterone Antagonists
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Wondering if there is a testosterone metabolite or topical estrogen / progesterone blocker that would work here?
*ABSTRACT
Northwestern University researchers have developed a new method of treating hernia with progesterone antagonists. By using a hernia-prone rodent model that expresses human aromatase, Dr. Serdar Bulun’s lab demonstrated that the conversion of testosterone to estrogen and the increased estrogen activity in the lower abdominal skeletal muscle tissues lead to fibrosis and hernia formation, a pathway that recapitulates aspects of hernia formation in elderly men. More importantly, progesterone receptor expression is regulated by estrogen receptor signaling, and progesterone treatment promotes hernia formation. Therefore, Dr. Bulun and his team at Northwestern developed a method that can be used to treat hernia in elderly men by blocking progesterone receptors using progesterone antagonists delivered orally or subcutaneously. In animal studies, progesterone antagonists prevented the formation of hernia and reversed the progression of small to medium sized hernia. This invention targets the underlying mechanism of hernia formation and appears to be one of the first non-invasive therapeutics for hernias.*
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I am afraid this is another sleight of hand trick the industry likes to pull. I have spoken on this forum several times about progestins which are not real progesterone and essentially do not serve the same functions, other than occupying so-called receptors or the proteins that house either estrogen or progesterone depending on the organism health status. There is one important idea to understand and why the terms estrogen or progesterone "receptor" are misleading. Since, in one state the very proteins that had progesterone occupying them can be analyzed and used as a point of reference for estrogen and vice versa, again, depending on the health of the organism itself. Therefore, guess what they do?? Use the receptor reference interchangeably! So where estrogen is truly causing an issue, it can on some twisted technicality be referred to as "progesterone receptor."
But at any rate, what substances are they using we must ask?! It is NOT progesterone. So in many of these studies where they investigate this idea of blocking estrogen AND progesterone to help hernias, they are using "P4 analog."
"8658 Role of Progesterone Receptor in Skeletal Muscle Fibrosis and Hernia Formation in Mouse Models and Men with Inguinal Hernias"
Funny enough, these charlatans ALSO love using interchangeable terms to try and convey an idea of ONE thing, when it is not ONE thing they are referring to. SO, in these studies, they are using progestins, under the guise of P4 analog, and you will notice, such as in the study I posted above, they casually and IRRESONBILY mention P4, progesterone and P4 analog throughout. But because they are using progestins and asserting that estrogen is the culprit in hernias, it is safe to then and logical to conclude it IS all about estrogen and nothing to do with progesterone other than the imposter progestins.
The next thing to take note of is WHAT they used in using this study as an example, referring to this hernia issue. That is RU486. The substance that although has anti-progesterone activity, is also a major cortisol inhibitor. SO much so, that even Haidut had shown several articles about how it is used for several ailments, but due to its cortisol blocking action and consequently, its heavy estrogenic blocking ability what can see AGAIN, this has all to do with blocking estrogen.
What this hernia bullshit is, is just another way to demonize progesterone, because the truth of estrogen, AS THEY THEMSELVES admit to when you read the article in the OP, is becoming clearer and clearer. Aromatase and estrogen are the true players in developing hernias. They clearly state that. Rather than trying to stop that, the better method is public obfuscation and vilifying progesterone as well. And that is what sets up a confusing study.
It is a funny thing I remember Dr. Peat mentioning in an interview how DHEA, and progesterone and pregnenolone should be first line defenses against hernias!
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@bio3nergetic - Thank you. I truly enjoyed reading your post.
More hernia information from Dr. Peat:
“…The cortisol weakens your connective tissue, tends to create things such as hernias. And the DHEA with aging declines while the cortisol, if anything, tends to rise with aging. And so, fixing your nutrition, vitamin D, calcium, thyroid function will help to raise the DHEA concentration relative to cortisol. And what would be some foods that might help this hernia, kind of you think? Oh, high protein foods. Eggs. Eggs. Seafood. Shellfish in particular. Copper is one of the minerals needed to make strong connective tissues. That would be like lobster, shrimp? Oysters. Oysters. Stuff like that.”
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@DavidPS Thanks, and as always thanks for the supplementary info, that's perfect.
