Thoughts on autoimmunity
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Hi! I am just curious if anyone wants to explain Haidut's views on autoimmunity. I understand that there are some main mechanisms that can contribute to 'autoimmunity' which I think is really that the body has immune dysregulation due to a chronic stressor more than it is 'auto'. But this is my understanding: 1. Chronic inflammation leading to DAMPs and immune response responding accordingly however due to continued stimulus the DAMPs continue to be made and so tissue continues to be attacked, inflammation increases, and more DAMP and ROS production stimulating immune function further due to RAGE activation. This either contributes to gut inflammation or further dysbiosis there, which then activates further systemic inflammation via damaged tight junctions and LPS and further immune response. The intestinal permeability seems to be a prerequisite to me for any autoimmune reaction and failure of self recognition systems to maintain central and peripheral tolerance. Treg cells decrease due to increased IL-6 and Th17 cells are produced in higher numbers and histamine is constitutively being produced from chronic activation of mast cells. 2. this environment damages MHC class I complexes which then cause the immune cells to destroy those cells as they are indicating cellular damage. 3. Molecular mimicry - pathogenic presence such as prevotella, klebsiella, proteus, h pylori etc have similar structure to our own tissues and in the systemic inflammatory environment the ability to distinguish between self and non self when they are so closely similar is not able to be maintained and the immune system produces both Ta nd B cells which recognize self tissues. Gliadin can also be a main contributor here and has molecular similarity to many structures in the body including synapisn I, TPO, cartilage etc.
I understand that in the bioenergetic view and Haidut's view (of which I am a HUGE fan - I have learned so much from his work am super grateful and for his idealabs products) that autoimmunity in the current medical view is seen as 'idiotic' and that molecular mimicry does not play a role in these hyperinflamed conditions. I wanted to know what the view is of what is really happening, and if if molecular mimicry is not something that is considered to be occurring? Is it mostly DAMP activation that is thought to be happening? I have just seen a lot of literature about the molecular mimicry and though not a driving factor I think it does play a role and that the hyperinflamed environment leads to immune dysregulation at many points. I think the key is to restore gut barrier, eliminate pathogenic overgrowths or presence, and remove all stressors that are contributing to the chronic inflammation. I would love to hear some perspectives on this. Thank you!