How to lower Adrenaline
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Hi,
I am looking to lower my adrenaline levels. Read of:
- Niacinamide
- Glycine
- Taurine
https://raypeatforum.com/community/threads/lowering-adrenaline.4602/#post-55592 - Vitamin B6
https://raypeatforum.com/community/threads/vitamin-b6-may-be-anti-adrenaline-and-thus-anti-stress.3245/
However, I have never felt did a significant difference. Unfortunately I have hypothyroid symptons, high adrenaline/low cortisol, low vitamin D/A even supplementing with relatively high doses (10000-15000UI daily), cold sweaty feet winter, cold feet(sometimes hands also) and warm temp for the rest of the body, very skinny (always been) even eating garbage food or high calories.
Any suggestion on how to lower adrenaline? Already taking t3
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@fd Reducing adrenaline levels is supposed to be ad hoc, I assume?
High levels of stress hormones indicate adrenal hyperactivity, and targeted treatment should be considered.
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@fd Try increasing your intake of non-iodized salt. Maybe this will help
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@fd Clonidine from alldaychemist works. I use it sometimes and like it.
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@fd a beta blocker like propranolol.
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@fd salt all your food to taste.
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@fd Abstain from self-abuse. Seconding the suggestion to increase sodium intake.
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Eating sugar and/or salt reduces cortisol and adrenaline. Both at the same time will get you great results.
Make sure you eat enough sugar and supplement if needed with a candy or a sugary drink.
It’s best taken with salt.
My fav combos:
Jam + salt is awesome.
OJ + salt as well. -
@fd
Get your total calories checked for a few days in https://cronometer.com/
Check pulse (aim for 70+ at first), temperature, and usual symptoms you described.
The first step of upping your metabolism is increasing your caloric intake. Also more vitamin-rich foods (liver, dank seafood, etc.) because this will increase your needs as well.
Your hormonal levels aren't gonna magically restore if you don't have enough energy to support your metabolism. -
@fd Look into magnesium supplementation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761127/
"The hypothalamic–pituitary–adrenal (HPA) axis and the autonomic nervous system (comprising SNS and PNS) have been identified as the mediators of this neurobiological stress model [90,91,95]. First, corticotrophin-releasing factor (CRF) is secreted from the paraventricular nucleus in the hypothalamus; the subsequent secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary stimulates the release of glucocorticoids (mainly cortisol) from the adrenal cortex [97]. Noradrenaline (NA) and adrenaline are also released from the sympathetic nerves and the adrenal medulla, and together with the glucocorticoids regulate the stress response [90,91]. Cortisol also interacts with the serotonergic pathway, adjusting the release of serotonin (5-hydroxytryptamine or 5-HT) neurotransmitter in response to acute or chronic stressors [98]. Serotoninergic neurons modulate the stress response either via direct neurotransmission to the hypothalamus, or by stimulation of noradrenergic neurons [97]. In addition to the regulation through feedback mechanisms, the HPA axis is also modulated by other central systems, particularly by the inhibitory action of the γ-aminobutyric acid (GABA), and the excitatory effect of glutamate [99].In this neurobiological model, cortisol is a well-known mediator of the stress response. The nocturnal cortisol urinary excretion in apparently healthy subjects reflects the basal tone of the HPA axis [100]; conversely, the blood cortisol concentration measured in a challenging environment is a sign of stress activity [101]. It has been shown that cortisol coordinates the central response to stress at several levels [102], and indirectly influences mechanisms of neuroprotection [103]. Neurotrophic factor production, represented by the brain-derived neurotrophic factor (BNDF), intervenes in allostasis through protecting neurons [104]. Normally, BNDF promotes neuronal survival and plasticity [104]; however, changes in BNDF expression have been reported following exposure to stressful stimuli. An increase of BNDF has been observed in response to moderate stress [105], whereas a decrease has been associated with high levels of stress [106]. Furthermore, increasing evidence shows a link between cortisol responses and oxidant elevation [107]. The accumulation of free radicals and other reactive oxygen species is also a sign of allostatic load, resulting from the imbalance between cellular metabolic activities and antioxidant defense mechanisms [108,109].
Noteworthy, magnesium interacts with all these stress mediators [17,110,111,112], overall serving an inhibitory function in the regulation and central neurotransmission of the stress response (details of these interactions are summarized in chapter 6)."
-end paste-
Although Ray Peat did not discuss magnesium in depth, he did mention it multiple times and considered it very important. I remember he said that hypothyroid people have a "hard time holding onto magnesium".I personally have found that magnesium glycinate works well for me. I'm able to tolerate the suggested/recommended dose of 3100mg/day very well since I've been taking high dose thiamine hcl. Please note that 3100mg of thiamine glycinate = something like 400mg pure magnesium.
Peat did recommend thiamine multiple times; I remember that he said that if you consume more than ________ amount of sugar/carbs you'll need more thiamine to utilize it. My memory has recorded that the amount was that which is found in 2 quarts of milk + 1 quart of orange juice, but I don't have the link to that quote, sorry.
Sugar/carbs use up thiamine; thiamine (b1) is used as a cofactor for several enzymes in the Krebs cycle. If you develop a thiamine deficiency, real problems occur because oxidative metabolism is compromised.
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@mostlylurking said in How to lower Adrenaline:
@fd Look into magnesium supplementation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761127/
"The hypothalamic–pituitary–adrenal (HPA) axis and the autonomic nervous system (comprising SNS and PNS) have been identified as the mediators of this neurobiological stress model [90,91,95]. First, corticotrophin-releasing factor (CRF) is secreted from the paraventricular nucleus in the hypothalamus; the subsequent secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary stimulates the release of glucocorticoids (mainly cortisol) from the adrenal cortex [97]. Noradrenaline (NA) and adrenaline are also released from the sympathetic nerves and the adrenal medulla, and together with the glucocorticoids regulate the stress response [90,91]. Cortisol also interacts with the serotonergic pathway, adjusting the release of serotonin (5-hydroxytryptamine or 5-HT) neurotransmitter in response to acute or chronic stressors [98]. Serotoninergic neurons modulate the stress response either via direct neurotransmission to the hypothalamus, or by stimulation of noradrenergic neurons [97]. In addition to the regulation through feedback mechanisms, the HPA axis is also modulated by other central systems, particularly by the inhibitory action of the γ-aminobutyric acid (GABA), and the excitatory effect of glutamate [99].In this neurobiological model, cortisol is a well-known mediator of the stress response. The nocturnal cortisol urinary excretion in apparently healthy subjects reflects the basal tone of the HPA axis [100]; conversely, the blood cortisol concentration measured in a challenging environment is a sign of stress activity [101]. It has been shown that cortisol coordinates the central response to stress at several levels [102], and indirectly influences mechanisms of neuroprotection [103]. Neurotrophic factor production, represented by the brain-derived neurotrophic factor (BNDF), intervenes in allostasis through protecting neurons [104]. Normally, BNDF promotes neuronal survival and plasticity [104]; however, changes in BNDF expression have been reported following exposure to stressful stimuli. An increase of BNDF has been observed in response to moderate stress [105], whereas a decrease has been associated with high levels of stress [106]. Furthermore, increasing evidence shows a link between cortisol responses and oxidant elevation [107]. The accumulation of free radicals and other reactive oxygen species is also a sign of allostatic load, resulting from the imbalance between cellular metabolic activities and antioxidant defense mechanisms [108,109].
Noteworthy, magnesium interacts with all these stress mediators [17,110,111,112], overall serving an inhibitory function in the regulation and central neurotransmission of the stress response (details of these interactions are summarized in chapter 6)."
-end paste-
Although Ray Peat did not discuss magnesium in depth, he did mention it multiple times and considered it very important. I remember he said that hypothyroid people have a "hard time holding onto magnesium".I personally have found that magnesium glycinate works well for me. I'm able to tolerate the suggested/recommended dose of 3100mg/day very well since I've been taking high dose thiamine hcl. Please note that 3100mg of magnesium glycinate = something like 400mg pure magnesium.
Peat did recommend thiamine multiple times; I remember that he said that if you consume more than ________ amount of sugar/carbs you'll need more thiamine to utilize it. My memory has recorded that the amount was that which is found in 2 quarts of milk + 1 quart of orange juice, but I don't have the link to that quote, sorry.
Sugar/carbs use up thiamine; thiamine (b1) is used as a cofactor for several enzymes in the Krebs cycle. If you develop a thiamine deficiency, real problems occur because oxidative metabolism is compromised.
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@mostlylurking
EDIT: that's Magnesium Glycinate, NOT "thiamine" glycinate. Oops, sorry about the typo/error.Is there a way to edit posts after posting them?
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Thank you all.
I was taking:
- 500mg Magnesium Glycinate a day
Currently (just started):
- 500mg Magnesium Glycinate
- 1000mg Niacinamide
Soon I will add:
- Cardenosine (from idealabs)
Other things I take on a daily basis which I am unsure if that helps: Vitamin A, D, K, E, B1, T3.
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@fd The vitamin A supplementation is controversial; I just rely on my diet for vitamin A which does include eggs.
I've found lower doses of niacinamide to be more helpful; I take 100mg, 4Xday. I got better results taking it this way than taking 200mg, 2Xday. Niacinamide is water soluble so it doesn't stick around for longer than a couple of hours.
Which thiamine are you taking?
I found it really important to rely on a good endocrinologist to help me with my hypothyroidism. He spent 9 months optimizing my dose of desiccated thyroid supplement (NP Thyroid by Acella). He ran blood tests on me about every 6-8 weeks. It wasn't something that I could have done without him.
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Have you tried switching to a thyroid product that has some t4 in it as well? I've never really seen t3 on its own work for many people.
Thyroid should lower adrenalin eventually, once you get the dose right.
Do you have gut issues? they tend to cause a lot of adrenalin.
Taurine is pretty good at lowering adrenaline, or there's propranolol like somebody else mentioned.
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@mostlylurking said in How to lower Adrenaline:
@fd The vitamin A supplementation is controversial; I just rely on my diet for vitamin A which does include eggs.
I've found lower doses of niacinamide to be more helpful; I take 100mg, 4Xday. I got better results taking it this way than taking 200mg, 2Xday. Niacinamide is water soluble so it doesn't stick around for longer than a couple of hours.
Which thiamine are you taking?
I found it really important to rely on a good endocrinologist to help me with my hypothyroidism. He spent 9 months optimizing my dose of desiccated thyroid supplement (NP Thyroid by Acella). He ran blood tests on me about every 6-8 weeks. It wasn't something that I could have done without him.
Thiamine Hydrochloride, 500mg
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@fd OK. I take that one too. It's important to take it with water only and at least 30 minutes away from food. Dr. Costantini recommends to take half of the daily dose mid-morning and the other half mid-afternoon. If you take it late in the day it can interfere with your sleep by lowering your blood sugar.
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@fd I'd like to add that because thiamine hcl has very poor absorption through the intestinal wall, the dose of it needs to be pretty high to do much. Although I did get some benefit from taking 350mg of thiamine hcl 2Xday, I did not get full benefit until I started taking 1 gram 2Xday. After 2 days on that dose, my entire digestive tract normalized and I experienced massive improvement in my health. I follow Dr. Costantini's protocol for thiamine hcl. The dose is based on body weight.
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Cypro is your best friend. Thank me later.
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deleted for editing.
