Rapamycin: Anti-aging and metabolic dream drug?
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Azithromycin might have interesting anti-aging effects. It targets senescent cells very effectively and without targeting healthy cells. The effect is concentration dependant though .
"Azithromycin preferentially targets senescent cells, removing approximately 97% of them with great efficiency. This represents a near 25-fold reduction in senescent cells."
"Azithromycin, at 100 μM, had no effect on the viability of normal MRC-5 lung fibroblasts, but selectively killed only senescent MCR-5 fibroblasts."
"Neither drug showed any significant effects on viability at 50 μM, indicating that the effects we observed were concentration-dependent."
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@Mauritio I took approx 40 mg azithromycin plus .5g of cypro daily for about 3 weeks during allergy season, and I seemed to do better than with just cypro.
I've wondered if there would be any negative effects from longterm lowdose usage, like Peat's concern that using too much of one antibiotic causing imbalance in the microbiome.
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@LetTheRedeemed interesting . Did you notice any other effects from it ?
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@Mauritio I couldn't connect if I was having digestive issues connected to it's prolonged use or not. there were a lot of confounders at the time. I'll probably try it again next time I use it with some penicillin traveling el snail mail.
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I’ve not been that impressed with rapamycin personally, as it gives me a headache and interferes with sleep.
But low dose naltrexone and deprenyl are quite amazing and are great longevity drugs. LDN in particular has made a huge different for so many people as it can seal leaky gut — which is the source of virtually all chronic disease as we age.
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@Ecstatic_Hamster say no more, where does one get LDN?
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@Ecstatic_Hamster I've been wanting to try LDN for a long time . Is there anywhere we can read about people's experience with it ?
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@Mauritio said in Rapamycin: Anti-aging and metabolic dream drug?:
Surprisingly this review argued that quinones would increase mTOR.
Because quinones increase Nrf2 which in turn increases mTOR.What should we think of that ?
In theory that would cause a pro-cancer effect, but quinones do lot more than activating Nrf2 ...Here's a few studies that a quinone, thymoquinine to be precise, inhibits mTOR and thus has an anti-cancer effect.
https://pubmed.ncbi.nlm.nih.gov/37288949https://pubmed.ncbi.nlm.nih.gov/37288949/https://pubmed.ncbi.nlm.nih.gov/30259603/
https://pubmed.ncbi.nlm.nih.gov/36145344/ -
*I have heard it said that rapamycin is the leading longevity molecule because of the robustness of the literature in mice.
But what the literature in mice robustly shows is that it causes cataracts, testicular atrophy, and impaired glucose metabolism at doses beneath those that lengthen lifespan. When you get into lifespan-lengthening doses, this just gets worse. And other problems are added, like fatty liver and heart scarring.*
https://chrismasterjohnphd.substack.com/p/the-worst-longevity-idea-ever-conceived
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@Mauritio I tried LDN a few months ago, (with high hopes that it would help with my tinnitus). It didn’t do anything for me, (which I found incredible as I tend to respond to most supplements/medications). I titrated up from .5mg to 4-5, (I honestly forget) over the course of many weeks as is suggested, and finally in a last ditch effort, (after a few weeks off) took Peat’s recommended dose, (again I don’t remember but it was high, like half a pill or something, (Peat seemed to think Naltrexone was best in a high dose a single time or for 2-3 days)) and proceeded to be sick for the next day. My symptoms were just flat out nausea. Very unpleasant, not debilitating.
Never touched it again. Still have a number of pills left unfortunately. Just my personal experience, I have read many positive experiences and that’s why I trialed it.
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Results from a human study.
Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results (2025)
