Magnesium is as bad as serotonin when too high
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Too much of a good thing is bad. But How much and why?
Excess magnesium influence vitamin D3 status*) Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial
DOI: 10.1093/ajcn/nqy274 Am J Clin Nutr. 2018. Dai Qi et al.
https://www.casi.org/node/919 - December 28, 2018.
Excerpt:
According to a new randomized trial published earlier this month in the American Journal of Clinical Nutrition, researchers demonstrated that magnesium influences vitamin D status. Magnesium had a regulatory effect, with magnesium deficiency essentially shutting down the vitamin D synthesis and metabolism pathway.
The research team became interested in a role for magnesium because people respond to vitamin D differently, with levels of the vitamin in some individuals not rising even after being given high dosage supplements.
This randomized study included 250 patients 40 to 85 years of age at risk for developing colorectal cancer due to having had a precancerous polyp removed or having other risk factors. Doses of magnesium and placebo were customized based on baseline dietary intake.
Magnesium supplementation increased the 25(OH)D3 concentration when baseline 25(OH)D concentrations were close to 30 ng/mL, but decreased it when baseline 25(OH)D was higher (from ∼30 to 50 ng/mL). Magnesium treatment significantly affected 24,25(OH)2D3 concentration when baseline 25(OH)D concentration was 50 ng/mL but not 30 ng/mL.
As a result, optimal magnesium status is important and plays a role in optimizing vitamin D status.
By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS
Source: Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan, Harvey Murff, Reid M Ness, Douglas L Seidner, Chang Yu, Martha J Shrubsole. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial.
The American Journal of Clinical Nutrition, 2018.
https://ajcn.nutrition.org/article/S0002-9165(22)03058-1/fulltext
DOI: https://doi.org/10.1093/ajcn/nqy274*) julienvenesson.fr comment le magnésium contrôle nos niveaux de vitamine d
Le magnésium joue donc un rôle régulateur des niveaux de vitamine D dans le sang, aussi bien pour limiter les effets d’une carence en vitamine D quand celle-ci vient à manquer que pour limiter les effets d’un excès. -
Le niveau de vitamine D plafonne (Vitamin D levels plateau)
http://mirzoune-ciboulette.forumactif.org/t1598-le-niveau-de-vitamine-d-plafonne#19020
Une raison pour laquelle votre supplémentation en D3 ne fonctionne pas.
Idée clé: Si vous avez un statut de vitamine D inférieur à 30 ng/mL, vous devriez optimiser les apports de Mg mais pas plus que l’AJR car un excès de magnésium régule à la baisse la conversion de la vitamine D en sa forme active. Et si vous prenez un excès de vitamine D3, vous risquez d’épuiser le magnésium utile dans l'activation et la neutralisation de l'excédent de D3, mais également ailleurs (cofacteurs enzymatiques dans + de 300 réactions). Avec un impact possible sur un tas de pathologies, comme par exemple les crampes, les maux de têtes, de l’anxiété ou de l’insomnie...
Il faut donc trouver le juste milieu, le bon rapport. Plus de détails sur le lien.=> If your vitamin D level is below 30 ng/mL, you should optimize your magnesium intake, but not above the RDA, because excess magnesium downregulates the conversion of vitamin D into its active form.
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@ethan Glycine raises serotonin, glutamate, and NMDA. When in excess, it makes you more excitable, nervous etc.
But magnesium even suppresses your fight response, which is needed for assertiveness and boundary control
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@lobotomize But Glycine reduces Serotonin? https://pubmed.ncbi.nlm.nih.gov/7693110/
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@lobotomize said in Magnesium is as bad as serotonin when too high:
@ethan Glycine raises serotonin, glutamate, and NMDA. When in excess, it makes you more excitable, nervous etc.
But magnesium even suppresses your fight response, which is needed for assertiveness and boundary control
What dose you took, what form?
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@user1 complex 456 mg elemental daily, as I have a diet making up around +- 8 liters of milk daily
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@pittybitty in excess it increases it
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@lobotomize said in Magnesium is as bad as serotonin when too high:
@user1 complex 456 mg elemental daily, as I have a diet making up around +- 8 liters of milk daily
Ok. Calcium on its own doesnt contribute significantly and positively to any of the things you mentionned below:
It makes you compliant, less assertive, malleable, weak. It mutes your personality, makes you less funny, susceptible to suggestions because calcium isn't there to light up the warning signal on odd suggestions, etc. I had to learn it the hard way, Be careful out there
@lobotomize what else you eat beside milk these days? You can link if you already said it explicitly on another thread
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This post is deleted! -
- I said magnesium causes it, not calcium (it’s in the title of the thread).
- I said I drink milk and orange juice, use salt, liver once a week, and a couple of other things, but that has nothing to do with the thread. Please, if you don’t understand the english, use gpt to translate it into your native language.
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@lobotomize said in Magnesium is as bad as serotonin when too high:
- I said magnesium causes it, not calcium (it’s in the title of the thread).
- I said I drink milk and orange juice, use salt, liver once a week, and a couple of other things, but that has nothing to do with the thread. Please, if you don’t understand the english, use gpt to translate it into your native language.
I understand english better than you. You said magnesium has the negatives effects you listed due to calcium not being present, calcium in it self does not cause "assertiveness" "boundaries" and whatever else you mentionned. So the reason you get these effects from magnesium supp is potentially not related to calcium at all. Yes what else you eat has everything to do with this thread because it could explain why you get these effects from magnesium supp.
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Calcium is the brain's primary on switch, essential for neurotransmitter release and rapid neuronal firing. Magnesium
acts as a functional antagonist by providing a voltage-dependent block of NMDA receptors, physically plugging the ion channel to prevent calcium influx. While this prevents over excitation, excessive magnesium intake creates a state of hypo excitability.
This dampens neural signaling and reduces cognitive resilience, making you more susceptible to external suggestions and intrusive stimuli because your prefrontal cortex lacks the excitatory "voltage" required to critically filter or counteract incoming information. -
Assertiveness is a high energy cognitive state dependent on the rapid release of catecholamines. To hold your ground in a confrontation, your brain must fire at high frequencies to maintain alertness and retrieve words quickly. Excess magnesium directly inhibits the release of these "fight or flight" neurotransmitters. As a result, your brain senses its inability to fire at the necessary speed and defaults to a path of least resistance. You avoid confrontation not out of choice, but because the physiological "lag" makes verbal sparring feel mentally exhausting and impossible to win.
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Humor is an associative leap that requires extreme synaptic plasticity. Being funny relies onthe brain’s ability to instantly bridge two unrelated concepts to create a punchline. This process is governed by NMDA receptors When these receptors are chronically blocked by magnesium, your "associative speed" is throttled.
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Personality is expressed through dynamic emotional range the excitatory "peaks" that make you distinct. High magnesium levels induce emotional blunting by acting as a ceiling on neural activity. It doesn't just lower anxiety; it mutes the intensity of your character. By suppressing the excitatory signals that drive charisma, quirky behaviors, and individual "spark," magnesium rounds off your personality traits, leaving you as a muted, stoic, and less distinct version of yourself.
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@lobotomize did drinking more milk or high calcium foods or calcium supps quickly fixed the effects you got from magnesium?
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@user1 calc acetate did
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Do you take note of what foods you're consuming the calcium acetate around? Calcium acetate is the main ingredient in many phosphorus binders that are prescribed to those with kidney failure. It can still be great for the average person if you have excess phosphorus in a meal and are trying to balance out your Ca/Phos ratio in general.
However, if you're taking calc acetate as a supplement, and its coming in contact with any phos from food in the digestive tract, it should then effectively bind to form tricalcium phosphate which is then passed out in the stool without either mineral being absorbed. -
@sphagnum i take it with milk . Que viva el mejor
