Idealabs Supplements Review
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@alfredoolivas wut…
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i value kuinone way higher as its a reasonably priced way of getting what i think is legit k2 mk4 premixed . ive taken big doses and felt what i think are too much estrogen suppression , as well as liver detox effects
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@alfredoolivas yeah, well, Wikipedia might be fake news here
https://lowtoxinforum.com/threads/the-anti-cortisol-mechanism-of-progesterone.14590/
"...Cortisol binds both the glucocorticoid receptor and the mineralo corticoid receptor; progesterone binds both the progesterone receptor and the glucocorticoid receptor, for which it is an antagonist."
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@engineer If it were anti cortisol, we would see reductions in amino transferases such as ALT, AALP and GGT. They don't and may even increase it.
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@alfredoolivas so is Haidut's referenced study bogus?
another one:
https://www.lowtoxinforum.com/threads/the-anabolic-effects-of-progesterone.16381/
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@engineer It certainly isn't 85% as anabolic as methyltestosterone. Perhaps rodents convert progesterone into androgens via the backdoor pathway more than human
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@alfredoolivas does this have implications for 6-keto? If so, are there any other good GR antagonists comparable in safety to prog/6kprog?
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@engineer most steroids are really shitty at blocking the GR. Even trenbolone is a poor functional antagonist. Androgens exhibit their anti glucocorticoid effects by blocking the transport of the GR receptor to the nucleous.
Methyltrenbolone has the highest affinity iirc. It has such a long half life that it will constantly block it's receptor against the nanogram amounts of cortisol being produced every second.
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@alfredoolivas the big problem with all the trenbolone family members is the nasty secondary effects
https://lowtoxinforum.com/threads/trenbolone-experiences-log.37957
It sounds so good to have that much cortisol blocking but it otherwise isn't Peaty
Or is methyl tren different?
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@alfredoolivas hold on, since DHT is highly androgenic, doesnt that mean it would be anabolic as well? 11-keto is more resistant to metabolism so maybe it has a significant effect here? It appears as though 12 drops per day of 11-keto-DHT would cost the same as 25 drops of 6-keto-p4.
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Meldonium is wayyyyy better than pyrucet
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@heyman said in Idealabs Supplements Review:
Meldonium is wayyyyy better than pyrucet
what has Ray Peat said about it?
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@engineer It gets deactivated in muscle tissue. Even methylated DHT, mestanalone, which is resistant to metabolism, was classed as androgenic and not very anabolic
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@alfredoolivas now, even though it isn't directly anabolic, could it assist in achieving that goal by lowering cortisol and prolactin?
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@engineer I think prolactin is anabolic, if i remember correctly. It probably lowers cortisol via reduced AcTH
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@alfredoolivas cite some studies
I can't find anything saying prolactin is positive in anything but thymus regeneration and dopamine suppression/serotonin production
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@engineer I just knows it rises along with growth hormone
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@engineer Hypoprolactenmia, which can be achieved easily via caber use etc, is really bad though.
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You have been using all of these supplements within the space of 6 weeks? How are you able to accurately differentiate their effects? Not jabbing but could you detail your regimen?
Could you also describe the feeling of sugar burn and carb burn as well please? I took pyrucet for around 2 months and didn't 'feel' much of anything though I did notice effects on body composition etc...
