Aspirin is a true drug for COVID-19 – it inhibits binding of the spike protein to the angiotensin converting enzyme II (ACE2)
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Most of my readers probably still vividly remember the brutal censorship levied upon the public during the COVID-19 pandemic in regards to treatments that did not conform to the official narrative that vaccines, and only vaccines, are the way to stop the pandemic and protect everybody. One of the most censored and maligned such “alternative” treatments for COVID-19 was aspirin (as well as vitamin D). As early as April 2020, studies had already come out showing that people taking aspirin regular were at a much lower risk of getting COVID-19, experiencing severe disease course, or dying from the disease. At the time, the arguments presented by the “experts” against aspirin were that the findings did not make medical sense since aspirin is “just an NSAID” and as such could not possibly provide protection against COVID-19. Well, as my readers know quite well, aspirin has a multitude of direct enzymatic and receptor-level effects that go way beyond inflammation and Ray has done a fantastic job of describing them in his articles. He went as far as stating (multiple times) that taking aspirin even just 2-3 times weekly is a good prevention practice against not just COVID-19, but all viral conditions. Now, the study below provides perhaps the most direct and specific evidence as to why aspirin may help with COVID-19. Namely, it is well-known that the SARS-CoV-2 virus infects cells by binding to the ACE2 enzyme. This binding not only allows the virus to enter and hijack the cell, but also triggers a systemic inflammatory state due to the fact that the binding prevents the ACE2 enzyme from converting the highly inflammatory angiotensin II protein back into the much less inflammatory angiotensin I protein. It was precisely this accumulation of angiotensin II protein that triggered the systemic inflammatory reaction, which often results in a severe cytokine storm that killed so many COVID-19 patients. As such, drugs that either block the effects of the angiotensin II protein at the receptor level (losartan, telmisartan, etc), block the enzyme ACE1 (converting the less inflammatory angiotensin I into the highly inflammatory angiotensin II), or enhance the activity of ACE2 were also found to be highly therapeutic for COVID-19. It looks like aspirin falls into the last category and now there is direct evidence for its effects. Unfortunately, even the pharma drugs found to be beneficial for COVID-19 were mocked and the study authors intimidated into silence or retracting their studies, since such findings interfered with the massive PR campaign to ensure maximum vaccine uptake among the general public. Well, it is all too late now to help COVID-19 patients, but perhaps if (God forbid!) another virus targeting the same (or even distinct) pathway creates a worldwide pandemic, the study on aspirin below will be remembered and put to good use.
https://pubmed.ncbi.nlm.nih.gov/41573552/
“…During the critical phases of the Covid-19 pandemic, studies conducted by the Mario Negri Institute for Pharmacological Research (published in eClinicalMedicine, 2021; Frontiers in Medicine, 2022; The Lancet Infectious Diseases, 2023) suggested that the timely use of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, could reduce the development of severe disease and the need for hospitalization. The importance of NSAIDs in the early stages of respiratory diseases was reaffirmed by an independent study published in 2024. In a new study by the Mario Negri Institute, recently published in Frontiers in Immunology, researchers investigated the molecular mechanisms underlying aspirin’s effects on the structure of the “spike” protein, which enables the virus to bind to host cells. “Our work,” comments Luca Perico, first author of the study, “has shown that aspirin concentrations comparable to those achieved in humans induce structural modifications in the SARS-CoV-2 spike protein that limit its ability to bind to the ACE2 receptor on epithelial cells.” “These observations,” says Ariela Benigni, Head of Research at the Bergamo and Ranica (BG) sites, “were made in cultured cells and in experimental models, in which it was possible to document that aspirin reduces lung damage, fibrosis, and inflammation induced by the SARS-CoV-2 spike protein.” “Non-steroidal anti-inflammatory drugs should be taken in the early stages of SARS-CoV-2 infection, always following medical advice and never through self-prescription,” comments Giuseppe Remuzzi, Director of the Mario Negri Institute.”
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@haidut So this proves that ACE II is also not the enemy as they were encouraging the inhibition or blockage of said enzyme earlier on the plandemic. Progesterone and thiamine happen to also increase ACE II, which to me, as young people have highest stocks of, is the ultimate proof.
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@bio3nergetic said in Aspirin is a true drug for COVID-19 – it inhibits binding of the spike protein to the angiotensin converting enzyme II (ACE2):
So this proves that ACE II is also not the enemy as they were encouraging the inhibition or blockage of said enzyme earlier on the plandemic.
@haidut said in Aspirin is a true drug for COVID-19 – it inhibits binding of the spike protein to the angiotensin converting enzyme II (ACE2):
It was precisely this accumulation of angiotensin II protein that triggered the systemic inflammatory reaction, which often results in a severe cytokine storm that killed so many COVID-19 patients.
Hmm.
