Vitamin E Supplement
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Giving a try to this one:
https://a.co/d/7nXqgEO
from JapanHigh dose E has always been good to me interns of skin and joint health so excited to get back on it and see what happens.
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idealabs is my favorite
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Idealabs TocoVit is unique and very good. I also got great results from Healthnatura’s “Whole E”
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health naturas Whole E is insanely good. i take 5 drops from the dropper and almost insantly within 3 minutes or so reduction in puffy nipple symptoms, super anti prolactin.
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You can't inhibit transcriptions downstream of prolactin that fast, so whatever the alteration is, it has fuckall to do with prolactin..circulating prolactin can drop in minutes, but stromal oedema which is what puffy nipples is, would take weeks to change if the mechanism was related to anti-prolactin/tonic dopamine. It could be anti-histamine as how histamine and leukotrines mediate prostaglandins through mast cells can act pretty quick(not 3 minutes quick though) as its the least metabollically expensive form of immune activation and doesn't require transcription factors, HDAC, or DNA methylation. So whatever reason you have puffy nipples, has nada to do with it being mediated through prolactin.
There's no mechanism by which Vitamin E could be anti-prolactin either..it doesn't influence dopamine or the limbic system. It stabilises cell membranes, poorly scavenges peroxidised lipids(not really) and it modulates the function of prostanoids which is actually its main function..it basically can prevent lipids that haven't been used for beta oxidation from potentially being less "inflammatory" by preventing the LA in D6D from becoming AA by modulating COX enzymes away from "inflammatory"PGE2, or at least gamma tocopherol does that..alpha tocopherol is just generally shite, causes more problems than it solves, and i really don't grasp Peats obsession with it..it doesn't prevent peroxidised lipids, or scavenge them
Endocrine changes do not happen before your eyes.
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@CurmudgeonApple said in Vitamin E Supplement:
You can't inhibit transcriptions downstream of prolactin that fast,
Why can't you?
@CurmudgeonApple said in Vitamin E Supplement:
stromal oedema which is what puffy nipples is
Puffy nipples aren't always oedma, they can be due to nipple tissue growth
@CurmudgeonApple said in Vitamin E Supplement:
There's no mechanism by which Vitamin E could be anti-prolactin either..it doesn't influence dopamine or the limbic system.
But it does
https://pubmed.ncbi.nlm.nih.gov/1490755/ -
that is one study and the review much later doesn't seem to correlate with its findings(i actually can't find any other study in humans that supports that claim). the effects of vitamin E on sexual function are exactly what you would anticipate them to be if you actually understood what Vitamin E was and its limitations. you also glossed over my point that endocrine changes do not happen in 3 minutes. if you are claiming that endocrine mediated tissue regrowth let alone stromal oedema can be undone in 3 minutes then........
https://pubmed.ncbi.nlm.nih.gov/34769353/
since you lot love rodent studies so much
here is an earlier study directly contradicting the study you cited
https://link.springer.com/article/10.1007/BF01953770fact of the matter is prolactin is centrally mediated in the limbic system. there is no known mechanism by which vitamin E can directly influence (keyword)D2 receptors in these regions of the brain. Vitamin has little direct affinity for anything outside of its context and especially not GPCRs. it is a shite antioxidant and a lipid phase membrane stabiliser and also pretty poor at this too outside of cell cultures
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@CurmudgeonApple said in Vitamin E Supplement:
ou also glossed over my point that endocrine changes do not happen in 3 minutes. if you are claiming that endocrine mediated tissue regrowth let alone stromal oedema can be undone in 3 minutes then........
"Gynecomastia is the benign (non-cancerous) enlargement of male breast glandular tissue caused by a hormonal imbalance"
Glandular Enlargment does not mean Swelling From Fluid. No, glandular enlargment can't be undone quickly. But that is because it takes a while to break down. Nothing to do with prolactin transcription
@CurmudgeonApple said in Vitamin E Supplement:
here is an earlier study directly contradicting the study you cited
https://link.springer.com/article/10.1007/BF01953770I was quoting a human study, and this thread is about "supplementation". Using a deficiency animal model to disprove a human study on supplementation is nonsense.
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@CurmudgeonApple So inflamation can't affect dopamine/serotonin?
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I don't think you know what inflammation is to be honest or you wouldn't have framed it that way. your human study is beyond context specific. you are deliberately glossing over how Vitamin E functions to try win the internet like a true to form Peaty sad act. I can accept it probably has specific context in renal failure that led to the outcome of reduced prolactin, but to broadly apply that to any "anti-prolactin"claim would be retarded.
I am not getting into the semantic details of what constitutes prolactin induced nipple changes with you. the point is to frame them within the boundaries of what Vitamin E can plausibly do, and within such a short timeframe, which you seem to want to keep ignoring to justify the nonsense of Vitamin E being "anti-prolactin"which is the only nonsense being truly spewed here, and you only have one study to justify the claim and is to put it frankly, a rubbish study.
I used a rodent study to disprove your claim because the very same 1992 human study(the only one mind you) you yourself cited uses a rodent study to justify their claim of pituitary involvement, and reductions in prolactin. and i quote exactly from that paper itself, not the abstract you read from
"We found no articles about this in human beings, but
some animal experiments may cast light on the question.
As mentioned, Vitamin E, which
effects gonadal functions, has been tested in animals.
Akazawa and co-workers reported that in the vitamin
E-deficient animal the amount of Leydig cells and binding affinity of LH to Leydig cells were low (9). In
the vitamin-deficient group direct damage to the
testes has been found and pituitary function was
increased in order to compensate for this, as shown
in histological studies (19).
Cooper and co-workers showed that rats given a
diet lacking in vitamin E had lower testes weight than
rats given a normal vitamin E diet"please do keep moving goalposts
here is the first study they are citing
https://www.jstage.jst.go.jp/article/endocrj1954/29/3/29_3_287/_article
Are you denying that this paper is not used as narrative scaffolding for the paper you are clutching your pearls over?
more to the point though, the human study actually doesn't prove pituitary involvement of Vitamin E at all. the human study isn't even claiming anti-prolactin beyond the presumed mechanism extrapolated from rodent findings in the Discussion section. it is about restoring sexual function by "normalising"prolactin levels in people going through hemodialysis with ongoing uremic complications.
if i have to explain to you how this isn't evidence of an "anti-prolactin" effect and you don't understand the context as to why the prolactin levels are lower with the intervention, and how it has nothing to do with central mediation and has no value you can extrapolate broadly to Vitamin-E outside of this study or similar contexts, you aren't worth arguing with to be honest.
gonna put a pin in this here
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Bro blocked me??
@sunsunsun please forward this messsage:
"I don't care what studies the authors cited or what their subjective opinion is. The objective fact, we know in humans, is that in this subset of patients, prolactin was lowered by 66%. Vitamin E doesn't need to directly interact with the pituarity to exert it's effects. It blocks the production of fatty acid metabolites, and their metabolites, and the encompossing effects of them all. This directly can reduce serotonin/prolactin. So instead of asking the involvement of vitamin E in prolactin, ask your self what do these fatty acid metabolites do?
for example; Omega 3 metabolite blocked by vitamin E, increases prolactin
https://pubmed.ncbi.nlm.nih.gov/3921344/
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@CurmudgeonApple Bro blocked me??
@sunsunsun please forward this messsage:
"I don't care what studies the authors cited or what their subjective opinion is. The objective fact, we know in humans, is that in this subset of patients, prolactin was lowered by 66%. Vitamin E doesn't need to directly interact with the pituarity to exert it's effects. It blocks the production of fatty acid metabolites, and their metabolites, and the encompossing effects of them all. This directly can reduce serotonin/prolactin. So instead of asking the involvement of vitamin E in prolactin, ask your self what do these fatty acid metabolites do?
for example; Omega 3 metabolite blocked by vitamin E, increases prolactin
https://pubmed.ncbi.nlm.nih.gov/3921344/
"
