A new idealabs product idea.
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Mole rats have more saturated plasmalogens in their membranes reducing lipid peroxidation. This heavily contributes to their longer lifespans. Practically all plasmalogens supplements on the market are unsaturated which is high unfavorable. I think a saturated plasmalogen supplement alongside mitolipin would be fantastic for fortifying cellular membranes against stressors from different angles.
Theres even a theory on this subject called the The membrane pacemaker hypothesis. It posits that species longevity correlates with membrane lipid resistance to peroxidation; naked mole-rats exemplify this with DHA-poor, plasmalogen-rich profiles that minimize oxidative damage from ROS
Sound interesting? -
@user73636 said in A new idealabs product idea.:
membrane pacemaker hypothesis. It posits that species longevity correlates with membrane lipid resistance to peroxidation; naked mole-rats exemplify this with DHA-poor, plasmalogen-rich profiles that minimize oxidative damage from ROS
I like it. I think the synergy with Mitolipin could be remarkable.
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on rpf Hans says eating a few eggs is the equivalent of a dose of mitolipin
secondly, for the plasminogen support all you need is good thyroid function and saturated fats, right?
anyways what do u think of this study: https://link.springer.com/article/10.1007/s00018-019-03113-5
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@sunsunsun It would really depend on where you get the eggs from. The closest to mitolipin would be naturally raised, free roaming chickens that were fed meat, organs, eggs, fruit and got plenty of sun. Even then, you can't mimic the completely saturated form that is mitolipin. Now, whether one thinks it is overall simply better to get real, good quality food over any supplement, is another discussion.
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@sunsunsun as for the study, PUFA, not saturated fat, drives endotoxin circulation by increasing gut permeability and oxidative stress. Saturated fats are protective. The focus on TLR4 activation is a distraction; the real issue is endotoxin translocation as well as gut barrier breakdown. This increases more area in the body for endotoxin activity as well as absorption.
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@bio3nergetic said in A new idealabs product idea.:
@sunsunsun It would really depend on where you get the eggs from. The closest to mitolipin would be naturally raised, free roaming chickens that were fed meat, organs, eggs, fruit and got plenty of sun.
I had, a long time ago, extensively looked up the fatty acid compositions of eggs from hens fed significantly different feeds, including different oils/fats.
The resulting difference in MUFA,PUFA,SFA content of eggs were insignificant. The fatty acid composition of eggs remained surprisingly fixed both in absolute and relative terms. -
@CrumblingCookie Do you mean "research" or from actual chickens firsthand experience? My friends in the south who have their own chickens had eggs with fat compositions of 5g and 3g Total to saturated fat where as a typical commercial egg is 5g and 1.5g. They fed them absolutely no grains but did add in white rice along with meats, organs (especially liver), and fruit. They go crazy for watermelon especially!
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Research as in these below in particular where coconut oil / meal just mildly decreased oleic acid content, mildly increased omega-3 PUFA content but omega-6 PUFA remained the same.
And the free range to caged parameter didn't really change the general composition at all.
Those studies agree with an overall 33% SFA content. Interesting that your friends achieved 60%!
What's their average egg yield and weight? Peculiarly, egg weight is positively associated with linoleic acid content of the feed.Feeding meats to chickens is kind of odd unless you regularly have scraps from other animals like pigs or cattle which cannot be used otherwise. Fairly advanced high-tier self-sustainability in the agricultural cycle I'd say.
The Effect of Coconut Meal and Coconut Oil in Poultry Rations on the Performance of Laying Hens
Effects of lipid sources in the diet of laying hens on the fatty acid profiles of egg yolks
