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    Niacinamide does not inhibit lipolysis?

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      user73636
      last edited by

      Niacinamide (nicotinamide) does not significantly inhibit lipolysis in humans, unlike nicotinic acid (niacin), which acutely suppresses it via the HCA2 receptor (GPR109A) in adipocytes, reducing cAMP and hormone-sensitive lipase activity
      This distinction arises because niacinamide lacks strong binding affinity to HCA2, so it fails to trigger the same antilipolytic signaling seen with niacin infusions or treatments.
      This is the info i have seen
      Am i missing something?

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