Fenclonine

hwisdom

@alfredoolivas whats w modafinil beeing good for u, its mechanism is it beeing pro histamine

alfredoolivas

@hwisdom If i was doing stuff that was good for me, i wouldnt have an account.

hwisdom

@alfredoolivas hahahahahahaha oh wow

engineer

Last one

https://kevinmd.com/2025/11/a-cautionary-tale-about-pramipexole.html

I never thought I’d be the cautionary tale.

For decades, I worked at a financial company. I’m a youth sports coach, a husband, and a father of two. I’ve spent decades coaching, mentoring players, and proudly producing high school sports telecasts. I built a life around leadership, precision, and community.

But none of that prepared me for what happened when I was prescribed pramipexole (Mirapex) to treat Parkinson’s.

The warnings were there: compulsive behaviors, gambling, and hypersexuality. I read them. I nodded. I thought, That won’t be me.

But pramipexole doesn’t come for you like a thunderstorm. It rewires you slowly. Quietly. It doesn’t feel like addiction. It feels like urgency. Like logic. Like a voice that sounds like your own, telling you this next step makes sense. Until it doesn’t.

I lost control. I made choices that devastated my family. Financial ruin. Emotional collapse. The kind of betrayal that no apology can fix. And when I finally came out of the fog (when I tapered off the drug and the compulsive pull vanished), I was left with the wreckage. The clarity came too late.

Since tapering off pramipexole, the compulsive urge is gone. It’s not dulled. It’s not managed. It’s gone. I don’t feel the same pull, the same irrational need, the same hijacking of my thoughts. That switch, the one that used to flip without warning, is silent now.

But that doesn’t undo what happened.

I sit here now knowing that I have ruined the life of my family. I realize there is nothing I can do to change what my brain did under the influence of that drug. I gambled away everything that would have made a life for my children and my wife. What I’ve done is costing me more than I ever imagined: not just the money I lost, but the tax consequences that may prevent my children from finishing college, and burden my wife for the rest of her life.

And I still have Parkinson’s. That won’t get better. I will need help, help I won’t be able to give myself. And my wife won’t be able to be everything for me or for herself. I fear what that means for her. For us.

I feel useless. Guilty. Ashamed. Like I’ve taken a step backward. But I also know this: I’m not hiding anymore. I’m telling the truth. I’m seeking help. I’m writing every day. And even if I can’t fix what’s broken, I can make sure no one else walks into this blind.

Here’s what I need you to understand: The risks and warnings won’t protect you.

You can read them. You can believe you’re immune. But pramipexole doesn’t ask for permission. It changes how your brain processes risk, reward, and impulse. And by the time you realize something’s wrong, you may already be deep in it.

This isn’t just a medical side effect. It’s a neurological hijacking. And it nearly cost me everything.

If you or someone you love is taking pramipexole (or any dopamine agonist), please don’t dismiss the risks. Monitor behavior. Ask hard questions. Don’t wait for the damage to show up before you act.

I’m not asking for forgiveness. I’m asking for awareness, for accountability, and for a system that doesn’t bury these risks in fine print. And for families to know that if something feels off, it might be more than just stress. It might be the drug.

This is my story. And I’m still living it.

RAY. PEAT. Wonder if he was laden with estrogen and PUFAs!

engineer

The connection between dopamine and serotonin

https://haidut.me/?p=2830

It just so happens that dopamine and serotonin have an inverse relationship. Each one suppressed the levels of the other. Thus, when serotonin is high dopamine is low and vice versa. That relationship extends to synthetic molecules that mimic the effects of serotonin or dopamine at the receptor level. For example serotonin agonists suppress dopamine synthesis and vice versa.

Serotonin (5-HT) promotes blood vessel thickening, may cause cardiovascular disease (CVD)

Serotonin (5-HT) may drive brain/liver/pancreatic and many other cancers, at the genomic level

Serotonin (5-HT) increases inflammatory mediators (IL-6, NF-kB), may cause atherosclerosis

SSRI drugs, serotonin (5-HT) can cause chronic fatigue syndrome (CFS)

Blocking serotonin may treat obsessive-compulsive disorder (OCD)

Drop in dopamine behind giving up

And it goes on and on and on!

https://haidut.me/?s=serotonin

Looks like maybe microdosing a DA could be the way to go?

Edit: Looks like the weird side effects from DAs are truly just a stress response?

https://lowtoxinforum.com/threads/dopaminergic-drugs-like-bromocriptine-may-treat-alcoholilsm.11828/