Iodine prevents lipid peroxidation, induces cancer cell apoptosis, antioxidant, immunomodulator, more than doubles tesosterone
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https://doi.org/10.1007/s12011-021-03066-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865438/
https://www.mdpi.com/1422-0067/24/12/9869
Also seems to convert arachidonic acid ( The most dangerous PUFA ) into the safer iodonolactone:
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I'm still doing a high dose iodine experiment I began a few months ago (posted progress reports on the RPF). I've taken as much as 1 gram but settled in at between 300 - 500 mg. I'm still alive and functioning and seem to be recovering from a 4th round of covid. This time it was very mild. Fever and fatigue for 1 day, whereas the other 3 times it lingered for 2 weeks to 2 months.
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I wonder why Ray was so cautious about high dose iodine therapy.
Dr. Peat: “A dosage of 150 mcg (micrograms, not milligrams, e.g., ug not mg) is a safe amount of iodine. There are excellent references describing the effect of a moderate iodine excess (even below a milligram per day) on the thyroid. An iodine deficiency can cause hypothyroidism (rare now), but so can an excess. Iodine deficiency is an unusual cause of hypothyroidism, except in a few places, like the mountains of Mexico and China, and the Andes.
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@Ray-Peat-Fanboy That's still a mystery to me as well. Maybe he read about the Wolff-Chaikoff effect and went no further? WC effect has been debunked or I would be afraid to take the high amounts I've been taking for several months.
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@Ray-Peat-Fanboy One of Peat's biggest inspiration (St Gyorgi) heaps praise on Iodine, so it may just be that Peat had an initial bad reaction to iodine (can happen because of Herxheimer detox reaction) and that made him look at the evidence with a bias, sort of like his initial experience with marijuana tea. The Japanese have staggering intakes of iodine and they show lowest incidences of thyroid diseases, obesity and CVD.
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@thyroidchor27 Makes sense
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For those who've supplemented directly with iodine, I have some questions:
- Firstly, what was the objective of iodine supplementation; and was that achieved?
- What kind of iodine was taken?
- In what form was the iodine taken?
- At what dosage and frequency were benefits noticed?
- Conversely, at what dosage and frequency were side effects noticed?
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@cornwallis That's a lot of typing! I'll try and answer some of these as I can. I currently take 40 mg Lugols that I mix up myself and 300 mg potassium iodide, daily. Im not consistent. Sometimes I take more, sometimes less.
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@S-Holmes No obligation to answer all of them! I appreciate your response.
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Yeah that seems like it.
I like the idea of iodine displacing fluoride. Would you say that it displaces fluoride at a 1:1 ratio? 1 mg of iodine removing 1 mg of stored fluoride?
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@S-Holmes How has the Wolff-Chaikoff effect been debunked?
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@brad
Wolff-Chaikoff critique
https://www.optimox.com/content/Iodine Research Resources/IOD04.pdf -
Here are a couple of examples of Ray’s view :
“High dose iodine can suppress TSH, since TSH is pro inflammatory iodine can have some anti inflammatory actions but in the long run thyroid suppression becomes a problem”
Also
“ Iodine reacts easily with toxic PUFA to make anti thyroid molecules “
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@Old-School said in Iodine prevents lipid peroxidation, induces cancer cell apoptosis, antioxidant, immunomodulator, more than doubles tesosterone:
Here are a couple of examples of Ray’s view :
“High dose iodine can suppress TSH, since TSH is pro inflammatory iodine can have some anti inflammatory actions but in the long run thyroid suppression becomes a problem”
Also
“ Iodine reacts easily with toxic PUFA to make anti thyroid molecules “
Lab rat here. I've struggled with hypothyroidism my whole life. I've been a fan of Dr. Peat for more than a decade and still am. His seed and nut oil information was a real game changer and may have saved my life, and I still use his Progest-E and have for many years. But I could never bring my temps up (except under stress). I'm now consistently 98.5 throughout the day. I'm thinking the iodine (and iodine symporters) I'm taking have really helped. The experiment continues.
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@Old-School Yea I know. I disagree with him on this and carotene
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@Ray-Peat-Fanboy I also know many who are on brownstein iodine protocol and feel great. I think what Ray and the studies which showed poor results missed the fact that Iodine supplementation should be supplemented with the supporting nutrients such as selenium, salt, vitamin c.
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@ora said in Iodine prevents lipid peroxidation, induces cancer cell apoptosis, antioxidant, immunomodulator, more than doubles tesosterone:
@Ray-Peat-Fanboy I also know many who are on brownstein iodine protocol and feel great. I think what Ray and the studies which showed poor results missed the fact that Iodine supplementation should be supplemented with the supporting nutrients such as selenium, salt, vitamin c.
I take Lugols that I make at home using iodine plus potassium iodide granules. I buy them from a local compounding pharmacist.
Iodine expert Dr. Jorge Flechas says many who don't do well taking Lugols or potassium iodide have a defective sodium/iodide symporter, and that should be addessed before taking iodine. Here is a good explanation of the symporter defect and how to repair it. -
You got the red pills on arachidonic acid as the most dangerous PUFA?