is it fine that cyproheptadine and ondanestron increase serotonin in certain brain areas?
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@thyroidchor27 you are right, i was thinking of @Ecstatic_Hamster
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A more effective and elegant way to lower serotonin is through the endocannabinoid system.
There is a retrograde process where endocannabinoids suppress serotonin for reals.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766225/
In the present study, using whole-cell recording from DR 5-HT neurons, we examined the effects of eCBs on glutamatergic synapses in the DR.
We found that the eCB anandamide decreased the amplitude of evoked excitatory postsynaptic currents (eEPSCs). This effect was blocked by CB1 receptor antagonist N-(piperidin-1-yl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM 251) and mimicked by (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate (WIN 55,212-2), a CB1 receptor agonist.
The inhibition of eEPSC amplitude was associated with an increase in the paired-pulse ratio and coefficient of variance. Activation of CB1 receptors also reduced the frequency, but not the amplitude, of miniature excitatory postsynaptic currents, indicating that eCBs inhibit glutamate release in the DR. I
n addition, we found that depolarization of DR 5-HT neurons induced a transient inhibition of the amplitude of eEPSCs, termed depolarization-induced suppression of excitation (DSE).
The induction of DSE required an increase in postsynaptic intracellular calcium and was due to a decrease in glutamate release. Furthermore, pharmacological studies showed that blockade of CB1 receptors with AM 251 abolished the DSE. In contrast, activation of CB1 receptors with WIN 55,212-2 mimicked and occluded the DSE, indicating that depolarization of DR 5-HT neurons triggers eCB release, which in turn mediates the DSE. Together, these results indicate that eCBs play a role in modulating glutamatergic synaptic transmission to DR 5-HT neurons
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@Ecstatic_Hamster said in is it fine that cyproheptadine and ondanestron increase serotonin in certain brain areas?:
anandamide
Hey Ecstatic, do you have a source for anandamide?
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@BronzeAgePater cannabis
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@Ecstatic_Hamster whats the best CBD to THC ratio and is it ideal when you dont notiecably get high (So that the CBD is outweighing the THC in the body ie)
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@Ecstatic_Hamster thanks
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@thyroidchor27 depends on how you take it and the type.
If you put potent THC into cocoa butter and use it rectally you won't get high even with huge amounts of THC.
Raw THCA is the THC precursor that is not heated up and it doesn't make you high either.
CBD can stop the psychoactive properties of THC to a great degree also, maybe a high amount of CBD and relatively small amounts of THC.
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@Ecstatic_Hamster thank you for response. im too low iq to comprehend it tho ngl, so i just smoke cannabis?
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@Ecstatic_Hamster I read somewhere that cannabis increases AA and 2AG by inhibiting their breakdown. This would be counterproductive ?
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@thyroidchor27 why woudl that be counter productive exactly?
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@Ecstatic_Hamster https://www.researchgate.net/publication/274260637_Elevation_of_Plasma_2-Arachidonoylglycerol_Levels_in_Alzheimer's_Disease_Patients_as_a_Potential_Protective_Mechanism_against_Neurodegenerative_Decline
Haven’t gone deep but it seems it rises as a preventative mechanism for further damage but I’m not convinced. It’s maybe an inferior backup like adrenals when thyroid goes? Need to do more research. Know any good book on the cannabinoid sys and how cannabis influences it?
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@thyroidchor27 said in is it fine that cyproheptadine and ondanestron increase serotonin in certain brain areas?:
@Ecstatic_Hamster https://www.researchgate.net/publication/274260637_Elevation_of_Plasma_2-Arachidonoylglycerol_Levels_in_Alzheimer's_Disease_Patients_as_a_Potential_Protective_Mechanism_against_Neurodegenerative_Decline
Haven’t gone deep but it seems it rises as a preventative mechanism for further damage but I’m not convinced. It’s maybe an inferior backup like adrenals when thyroid goes? Need to do more research. Know any good book on the cannabinoid sys and how cannabis influences it?
I don't know of any good book on it. Dr. Michael Moskowitz' book is good but it's maybe 6 years old.
There seems to be evidence that CBD can increase neurogenesis.
I think these pathways are incredibly powerful. I think Georgi told me he feels that CBD or THC may lower serotonin independently through the HT1 receptor, which suppresses serotonin.
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@Ecstatic_Hamster Is a 2:1 cbd to thc ratio oil good if taken in just the right amount that a perceptible THC induced dysfunction in thinking isnt noticed?
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@thyroidchor27 probably. Some ratios of 10:1 or 30:1 CBD:THC may even be better for most health issues.
