Thanks for sharing.

Activation of the PXR/SXR is an interesting thing in and of itself. It increases phase 1,2 and 3 detoxification in the liver and increases CYP3A4. Other ligands are for example: progesterone, 5aDHP or bile acids.

The authors of this study hypothesize that the liver-regenerating capabilites of Vitamin K2 were reliant on PXR-activation.

All the nucelar "X" receptors are really interesting, the FXR probably beeing my favorite.

PXR/SXR also upregulates a protein that takes up and excretes prostaglandins. So vitamin K leads to less PUFA/prostaglandin metabolites and damage.