@basebolt Thanks! Wow 150mcg I'm only at a sip and im on my second week and this morning I experienced a stress response. Woke up with a beating heart and sweating. I already have high heart beats from estrogen and adrenaline. I can't imagine getting to 150mcg from the get go. Will staying on T3 deplete T4 too much or should that not be an issue since my liver is dysfunctional and overburdened? I am on high dose progesterone for 6 months, so its certain the T3 caused the stress response. What does my reaction to T3 tell you about my situation?