Dandruff or scalp irritation? Try BLOO.

    Bioenergetic Forum
    • Categories
    • Recent
    • Tags
    • Popular
    • Users
    • Groups
    • Register
    • Login

    Vitamin A deficiency impairs gonadal steroid synthesis

    Literature Review
    7
    10
    636
    Loading More Posts
    • Oldest to Newest
    • Newest to Oldest
    • Most Votes
    Reply
    • Reply as topic
    Log in to reply
    This topic has been deleted. Only users with topic management privileges can see it.
    • J
      jamsey
      last edited by jamsey

      Got banned before I could post this
      https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1165941&blobtype=pdf

      “Earlier nutritional work had shown that vitamin A deficiency affects the reproductive processes of both male and female rats (Moore, 1957). Later sustained work by Grangaud and his colleagues (Grangaud et al., 1969) with whole living animals and with isolated enzyme systems from adrenals has produced extensive evidence showing that normal synthesis of steroid hormones in male and female rats is dependent on the Vitamin A nutritional status of the animals…..We have further investigated the effect of vitamin A deficiency on steroidogenesis in rat tissues and report here that even at the mild stage of the deficiency the activity of yet another enzyme, the cholesterol side-chain cleavage enzyme (cholesterolC(20)-C(22)desmolase), is significantly decreased in the ovaries and testes this becoming more pronounced with the progress of the deficiency”

      Results:
      Wasn’t sure how to add pictures, so I’ll summarize. Compared to the control group, the mild deficiency group had:

      • ~50% of the cholesterol side-chain cleavage activity
        -35% testes weight

      acute deficiency group had:

      • ~29% of the cholesterol side-chain cleavage activity
        -32% testes weight

      Mild deficiency group after 30 days of retinyl acetate supplementation had:

      • ~105% of the cholesterol side-chain cleavage activity
        -60% testes weight

      Just to clarify, cholesterol side-chain cleavage enzyme converts cholesterol to pregnenolone

      KvirionK 1 Reply Last reply Reply Quote 0
      • KvirionK
        Kvirion @jamsey
        last edited by

        @jamsey Interesting one, thank you!

        A little learning is a dangerous thing ;
        Drink deep, or taste not the Pierian spring :
        There shallow draughts intoxicate the brain,
        And drinking largely sobers us again.
        ~Alexander Pope, An Essay on Criticism

        1 Reply Last reply Reply Quote 0
        • V
          Verdad
          last edited by

          Thanks for sharing. Do you think you would have been banned if you had posted this? Im nervous now to even post anything on the ray peat forum that is pro-vitamin A

          J 1 Reply Last reply Reply Quote 0
          • J
            jamsey @Verdad
            last edited by

            @Verdad
            Probably not immediately as he tries to disguise the fact that he bans dissenters. It will just make you an auto ban if you complain about the forum or any of his questionable choices.

            1 Reply Last reply Reply Quote 0
            • sphenoidS
              sphenoid
              last edited by

              Screenshot 2024-02-18 085932.png

              The vitamin A movement could be a possible pop control psyop

              S 1 Reply Last reply Reply Quote 0
              • MauritioM
                Mauritio
                last edited by

                Great points. You can get too much Vitamin A, but you can certainly get too little.

                To clarify what you said: if your Vitamin A is low, you will get a pregnenolone deficiency, since the side chain cleaveage enzyme converts cholesterol to pregnenolone. Pregnenolone was peats one supplement he would take on a lonely island with him for a reason and he often repeated how you need T3 and Vitamin A to turn cholesterol into hormones and bile acids.

                Dare to think.

                My X:
                x.com/Metabolicmonstr

                J 1 Reply Last reply Reply Quote 0
                • S
                  saturnuscv
                  last edited by

                  So this means that Charlie will not reproduce. Good.

                  1 Reply Last reply Reply Quote 0
                  • J
                    jamsey @Mauritio
                    last edited by

                    @Mauritio
                    Yep, I had repeatedly read Ray or others mentioning retinol as necessary for steroid synthesis, but I could never find the mechanism until recently.

                    1 Reply Last reply Reply Quote 0
                    • MauritioM Mauritio referenced this topic on
                    • MauritioM
                      Mauritio
                      last edited by

                      https://pubmed.ncbi.nlm.nih.gov/26303142/

                      Dare to think.

                      My X:
                      x.com/Metabolicmonstr

                      1 Reply Last reply Reply Quote 0
                      • S
                        S.Holmes @sphenoid
                        last edited by

                        @sphenoid said in Vitamin A deficiency impairs gonadal steroid synthesis:

                        Screenshot 2024-02-18 085932.png

                        The vitamin A movement could be a possible pop control psyop

                        Disturbing! I'm not too concerned about the fertility of older people who go low A, but the young people and children who have to eat what their low A moms prepare. I sure hope this is reversible.

                        1 Reply Last reply Reply Quote 0
                        • 1 / 1
                        • First post
                          Last post