ADHD, Severe fatigue, digestion problems etc..

I would but I don’t have the energy to go to the doctors anymore.

Also they just say it’s anxiety or something. But I will have to try.

brightside

@questforhealth

Going to doctors for such tests is useless, since there is a good chance that they are using outdated testing.

I'd get a stool and urine (and mycotoxin) test from Mosaic diagnostics. It's pricey, but you can take it at home.

Practitioners who've been using them have started noticing various things like clostridia metabolites inhibiting dopamine conversion to norepinephrine, leading to things like ADHD. They also keep changing and expanding their tests, so they are very much at the frontier of human testing, versus the typical tests you might get.

I think there's a few other stool tests from other companies, but overall I think the urine one might be a bit more informative? Although it wouldn't point out things like parasites.

@questforhealth said in ADHD, Severe fatigue, digestion problems etc..:

@mostlylurking

I have had big improvements from large doses in the past actually. Although it didn’t help everything.

I’m not sure if this is maybe some trauma causing energy flow to be stuck in my body man. I really don’t know. I’ve tried all this sort of stuff and it works for a short while then goes bad again.

I remember when I was going through being so sick with thiamine deficiency/functional blockage and I was just starting to take higher doses of thiamine hcl. I started with around 300-350mg, 2Xday, with water, never juice. The dose would work for a week maybe 10 days and then it sort of stopped working. Each time that happened, I increased the dose.

My gut was a real mess and Ray Peat had advised me to take thiamine hcl + magnesium (I use magnesium glycinate). He had said not to take more than 1500mg of thiamine hcl/day. But he also told me that if I had heavy metal poisoning (which I did) that all bets were off. Four months later, I had worked my way up to taking 750mgs, 2Xday and I felt that I needed to increase my dose yet again because the effect was wearing off again.

I searched on line for more information and I found Dr. Costantini's website. His Therapy page includes conversion information for how much oral thiamine hcl you need to take daily for 7 days to equal a single 100mg injection of thiamine hcl taken each week. It's a LOT. According to that info, based on my weight, my optimum dose would be 2 grams/day, divided into two doses.

So I increased my dose to that recommendation. Within two days my digestive tract normalized for the first time in decades. Suddenly I could swallow food and my stomach could make stomach acid so I could digest the food, and my intestine was working and I could poop like a normal person. I was really hungry for a steak; so I ate one (actually three over three days).

My health continued to improve over the next 6 months. Then the improvements tapered off but didn't go away. It's been 3 years, I'm still taking 1gram of thiamine hcl, 2Xday and I'm still doing very well. I also take magnesium glycinate (3100mg, divided into 2 doses daily), riboflavin (100mg, 4 X day), niacinamide (100mg, 4Xday), selenium (200mcg/day), zinc (15mg/day) and I also drink orange juice for the potassium. I take a few other things, but these are the ones that people like Elliot Overton advises to take so you don't get into trouble high dosing thiamine.

If you have had improvements from taking large doses of thiamine in the past, I think your body has given you clues to what it needs in order for you to get well.

I found watching Dr. Costantini's patients' before and after videos enormously helpful. I'd like to encourage you to take the time to watch them. Each is very short and they're all in Italian (but some interviews have subtitles).

Dr. Costantini's FAQs are full of hands on wisdom regarding how to get better on his protocol. His research papers are hiding under Blog Posts.

Yes, I think you are exactly right; your body's energy flow is blocked; I think it's because of your thiamine deficiency.

I did try to take 2.5 grams of thiamine hcl one day in early 2021. That night, when I went to bed, I got shooting electrical zapping pains in my thighs. I interpreted that to mean that I had overdone the thiamine dose so I went back to taking the 2 grams/day and have never had another problem. My chiropractor told me that taking the thiamine was "messing with my body's electrical system". I believe he was right about that.

brightside

@questforhealth I second @mostlylurking's advice.

B1 is your first easy step towards improved gut and brain function. It's silly not to use it, IMO.

I just took some down the hatch. Lost my scoop so I just put some on the top of a teaspoon.

I HEAVILY suspect heavy metal problems. So probably should be doing thiamine.

@questforhealth said in ADHD, Severe fatigue, digestion problems etc..:

I just took some down the hatch. Lost my scoop so I just put some on the top of a teaspoon.

I HEAVILY suspect heavy metal problems. So probably should be doing thiamine.

Did you know that thiamine hcl is given to animals to save them from lead poisoning? It's in the Merk manual for veterinary medicine.

It's important to accurately weigh out your dose to make sure you are taking the correct amount and to be consistent about taking it so your body learns it can rely on it.

Here's a video and also an article for you:
Mega-Dose Thiamine: Benefits Beyond Addressing Deficiency (video)

Thiamine Saves (article)

@mostlylurking

Will a drug scale work? It’s pretty accurate. Crappy amazon micro scale thing

@questforhealth said in ADHD, Severe fatigue, digestion problems etc..:

@mostlylurking

Will a drug scale work? It’s pretty accurate. Crappy amazon micro scale thing

Yes. I weighed out my 1 gram dose with a little digital scale like that and then I found a little spoon that would hold that amount. I tested it out a few times so I knew the little spoon holds exactly the right amount (it holds 500mg, I use two of them); so now I just use the little spoon, not the scale.

@mostlylurking

That makes sense. Last time I felt good I had been taking 1 gram doses of thiamine every once in a while with b3 and methylene blue.

Might be worth trying that again along with magnesium. I may well need it until I chelate my heavy metals.

@questforhealth said in ADHD, Severe fatigue, digestion problems etc..:

I just took some down the hatch. Lost my scoop so I just put some on the top of a teaspoon.

I HEAVILY suspect heavy metal problems. So probably should be doing thiamine.

I'd like to add that Dr. Costantini advised to take your last dose for the day by 3:00pm. He said that if you take it late in the day that it can disturb your sleep. I think that the reason is that thiamine facilitates the burning of sugar for energy so it will make your blood sugar go down; if your blood sugar gets too low when you're sleeping, it will increase your adrenaline which will wake you up. If that happens and you want to go back to sleep, drink some orange juice with a pinch of salt or drink a glass of milk with a little sugar added (maybe 1 tablespoon to 10-12oz of milk).

Razvan

@questforhealth
Taurine should help for the digestion and also help utilize iron and copper better.
Be carefull with too much B1, it's very good indeed, but can raise acetylcholine too much to the point of making your racing thoughts much worse. Keep in mind what you feel and be aware of your experience even tho it's crazy hard to focus when having low iron and/or low copper.

@Razvan

I might try taurine. Yes the focus is insanely bad. It’s awful. Hopeful iron and thiamine will slowly improve this stuff.

My skin is so pale and sticky recently. What on earth.

@questforhealth said in ADHD, Severe fatigue, digestion problems etc..:

@mostlylurking

That makes sense. Last time I felt good I had been taking 1 gram doses of thiamine every once in a while with b3 and methylene blue.

Might be worth trying that again along with magnesium. I may well need it until I chelate my heavy metals.

The magnesium is a very good idea; I use magnesium glycinate. I get my thiamine hcl from purebulk.com too.

Methylene blue is really an iffy thing to use (in my opinion). If you are thiamine deficient, you can't clear serotonin out of your brain. The effect is like taking an SSRI. Methylene blue acts as an MAO inhibitor and should not be taken if you are taking SSRIs.

Serotonin Syndrome and Thiamine: Is There a Connection?

@mostlylurking

Oh I’ve had weird serotonin stuff before.

If I eat the wrong thing I feel like i’m on an ssri. Serotonin overload.

Razvan

@questforhealth Keep focusing on what we spoke in the other thread and I guarantee you will see improvements. After the focus on iron, its better to focus on copper. There is a trend when raising iron, copper can get even lower and then a period with higher copper foods will be needed.

Razvan

@Razvan Also having good thyroid function and good hormones will store less iron and preferably use it (that's what you need).

@Razvan

On a test my thyroid is good. But I do crave thyroid supplements. However I need to top up my vitamins first I imagine.

Razvan

@questforhealth
What kind of iron supplement are you taking? How much? And how do you feel from it even tho its early to tell?

@Razvan

Floradix.. some german brand with some herbs and berry juice and b vitamins. Not the best but better than having crappy filler. 15mg iron a day.

I do feel a bit better and maybe walking slightly more straight. Slow to tell yet.

@Razvan said in ADHD, Severe fatigue, digestion problems etc..:

@questforhealth
Taurine should help for the digestion and also help utilize iron and copper better.
Be carefull with too much B1, it's very good indeed, but can raise acetylcholine too much to the point of making your racing thoughts much worse. Keep in mind what you feel and be aware of your experience even tho it's crazy hard to focus when having low iron and/or low copper.

Actually, thiamine (B1) modulates acetycholine (I think) so the body is less likely to get overloaded with acetylcholine if your thiamine is adequate for your needs. The action of thiamine is extremely broad and complex. The following article is really above my pay grade; I'll slog through it another day, when I'm not as tired.

Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis
"Our interdisciplinary study shows that thiamin is not only a coenzyme for acetyl-CoA production, but also an allosteric regulator of acetyl-CoA metabolism including regulatory acetylation of proteins and acetylcholine biosynthesis. "