All things seizure disorders
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I wanted to start this thread because I think conditions such as epilepsy are very underdiscussed in relation to their prevelance, and there could be a lot to learn from them. To my knowledge this is the first thread on the subject on this forum.
Main topics:
-GABA
-Glutamate
-Neurosteroids
-Reseptors (NMDA, AMPA, GABA, etc.)
-Anticonvulsants
-Sodium channel
-Magnesium
-Seizures
-Possible remedies -
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Minerals too... Low copper low molybdenum can cause seizures.
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@AR04 https://www.sciencedirect.com/science/article/pii/S2214426921001300 megadose UMP stopped epileptic seizures in 2 days and stayed free
https://www.degruyter.com/document/doi/10.1515/tnsci-2018-0031/html?lang=en orally nobelitin protects against seizures in mice , restores gaba/glutamate balance, ~250mg heq
7,8 DHF has profound preventative effect but the dose is extremely important, high dose just 2x makes them worse than controls, where 1/2 the dose as low dose improved a lot. i would be cautious and go low, it was administered i.p so idk dose orally but being cautious matching as oral dose ~50mg-60mg human equivalent. and i would start with less. from my experience it felt like it lowered cortisol potently at 12.5mg - 25mg still
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723075/- The lower dose of 7,8-DHF almost completely prevented the occurrence of
SRSs in the observation period of 21 days. Whereas, as noted above, 14 of
17 vehicle-treated rats displayed spontaneous motor seizures, only 2 of 18
rats treated with 5 mg/kg 7,8-DHF experienced each a single motor seizure,
and this happened much later than in the vehicle group
@Peatful said in All things seizure disorders:
https://raypeat.com/articles/articles/epilepsy-progesterone.shtml
progesterone, thyroid / fixing hypothyroidism, vit E protection from PUFA, lowering pufa intake, carbon dioxide, good carb intake, foundation of protein intake to prevent edema, sodium, adenosine (& probably being cautious with caffeine) {UMP uridine study i posted is another nucleic acid like adenosine}, (peats article worth full read)
& not drinking too much water- It has been known for a long time that hyperhydration can produce seizures; at one time, neurologists would test for epilepsy by having the patient drink a pint of water. Although there are many reasons to think that the hyperhydration produced by hypothyroidism is a factor in epilepsy, physicians have been very reluctant to consider the possibility, because they generally think of thyroid hormone as a stimulant, and believe that "stimulants" are necessarily inappropriate for people with epilepsy. Pre-eclampsia and pregnancy toxemia have been corrected (Shanklin and Hodin, 1979) by both increased dietary protein and increased salt, which improve circulation, lower blood pressure, and prevent seizures, while reducing vascular leakiness.
- The lower dose of 7,8-DHF almost completely prevented the occurrence of
