Glucose loading cures everything?
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@S-Holmes It makes sense to me. If your brain is well fed, it can stop signalling the body to release/make more fuel, which can't get into the brain anyhow (due to stress and injuries). So the glucose stops the cascade by nourishing the brain, bypassing the digestive process and going directly to the brain where it's needed.
I've seen a more scientific explanation and will try and find it.
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@Insomniac I wonder if a person could fix a lot of health issues living on Mexicola and brewers yeast (plus B12 since it has none) for a while. Lol. (Not going to try it!)
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@Insomniac fructose converts to glucose in an oxidative metabolism. This is what I think is the missing piece for everyone here and at the RPF.
Most people come to Peat from carnivore, keto, fasting, etc. Those diets guarantee gluconeogenesis because the brain needs glucose to function, (the body too, but certainly the brain). Once you’ve converted from a high carb to a low or no carb diet you have manufactured a “glucose limiting injury.” This is the term used my Stephens. So, Stephens suggests you cannot recover without glucose, (possibly) or Peat suggests you can’t recover without restoring oxidative phosphorylation. THE PROBLEM IS: almost no one has used cynomel/cynoplus for three months with consistency. Peat spoke regularly about how T4 only doesn’t work, but it typically prescribed. Peat spoke frequently about NDT not working because it wasn’t standardized and you didn’t know what you were getting. But let’s face it, it’s a big leap to ask someone from keto/carnivore/fasting/veganism to trust big pharma and take thyroid hormone. I don’t blame anyone, it took me 5 years to finally take cynoplus, (and it’s the only thyroid that has worked for me).
So, you need oxidative phosphorylation, (thyroid supplementation) or glucose. 2 options, same outcome.
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ALS is the disease of athletes. Why?
Repeated injuries. With each trauma (emotional and mental as well), the body "CUMULATIVELY" downregulates glucose, creating a deficit cascade in the brain. What if we can prevent or even cure, all of the brain diseases with glucose? Since the brain is command central, how many other health issues could also be resolved?"...INCREASED GLUCOSE, transformed into energy, could give people with amyotrophic lateral sclerosis, or ALS, improved mobility and a longer life, according to new findings by a University of Arizona-led research team."
People with ALS use more energy while resting than those without the disease, while simultaneously THEY OFTEN STRUGGLE TO EFFECTIVELY MAKE USE OF GLUCOSE, THE PRECISE INGREDIENT A BODY NEEDS TO MAKE MORE ENERGY. Experts have not known exactly what happens in a patient’s cells to cause this dysfunction or how to alleviate it. “This project was a way to parse out those details,” said Manzo, who described the results, published online in eLife, as “truly shocking.”
"...The study revealed that when ALS-affected neurons are given more GLUCOSE they turn that power source into energy. With that energy, they’re able to survive longer and function better. INCREASING GLUCOSE DELIVERY TO THE CELLS, then, may be one way to meet the abnormally high energy demands of ALS patients. “These neurons were finding some relief by breaking down glucose and getting more cellular energy,” Manzo said."
“The fact that we uncovered a compensatory mechanism surprised me,” Zarnescu said. “These desperate, degenerating neurons showed incredible resilience. It is an example of how amazing cells are at dealing with stress.” The novelty of the findings partially lies in the fact that metabolism in ALS patients has remained poorly understood, Zarnescu said."
(Source: Georgi/Haidut)
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Caffeine adjunct to coffee may suffice, if that's not too "severe". Or something.
And it became a "toxin" to them.
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@evan-hinkle When I was very ill and found Dr Peat 15 plus years ago, I took Cynomel for several years. It may have saved my life, but I still had headaches, brain fog, fatigue, etc. I don't think I'm able to efficiently convert carbs to glucose.
This is only my third day on glucose and I woke this morning feeling pretty good. The experiment continues.
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@evan-hinkle Excellent analysis
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@S-Holmes interesting, did you ever use cynoplus? In my wife’s working with Danny, he suggested that some T4 was supportive of liver health. Your symptoms sound like low blood sugar/glycogen storage symptoms. Glucose to the rescue?
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@evan-hinkle this is not to say, cynoplus to the exclusion of cynomel, but in conjunction with.
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@evan-hinkle I take a 4 mcg dose of Idealabs Tyronene daily now. But nothing I have done seems to help as much as glucose (so far).
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Wouldn't you get thiamine deficiency from eating pure dextrose?
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@Insomniac said in Glucose loading cures everything?:
Does anyone have an opinion on that woman from the case study eating 2lbs of sugar/glucose on top of her regular diet for 5 months? Can that be right?
@Insomniac said in Glucose loading cures everything?:
By 5 th appointment she was taking between 200 and 240 grams 4 times per day, which eliminated all symptoms. She continued on this dose for 5 months, at which time all symptoms had been eliminated for a month and she discontinued use of glucose apart from occasional doses of 20 to 40 grams during times of high stress. Neuropsychological test scores at the time of completion of treatment ranged from the 84 th to the 97 th percentile.
How did a 63 year old woman eat that much for 5 months? Eating nearly 3200 cals of dextrose powder per day and she's certainly diabetic after 5 months. It's not impossible but it's hard to imagine a doctor telling someone to gain weight like that.
Seems possible to me, but only depending on a lot of missing information.
They may have been that hungry (and that thirsty) after commencing this "protocol". Discarding most of the calories by polyuria. And all or part of what was being "normalised" was cerebral edema. Without continuing the "regular diet" and drinking more, they may experience osmotic diuresis and weight loss. Possibly. It would mess them up.
If it works, it works. But it seems to me like a very disgraceful way to go about it.
This is all quite interesting none the less. Cardiac, renal and pulmonary function are very interlinked (well, it all is but...).
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They don't like fructose. I wonder why.
And they don't like caffeine. Hmm.
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@Insomniac said in Glucose loading cures everything?:
Can someone who isn't diabetic lose a large amount of glucose through the urine if they take enough?
Yes.
Osmotic diuresis is a "normal" "kind" of "overflow". It's conditional. And there are more reasons than overconsumption for blood elevation in "diabetes".
(More than happy for someone to come in here, tell me I'm wrong and school me.)
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Why does this make sense to me? If, due to repeated stress/aging, the body is no longer able to feed the brain via gluconeogenesis, eating a normal healthy diet, and you must have a fully functioning brain to be well and to restore that vital process, why not deliver pure fuel to the brain to aid recovery? If the brain can't recover, the body will never recover. Now the $64,000 question. Will this therapy actually work? I won't know for sure until I test it out. (Day 5).
