MMC ACTIVATION DETOX - Migrating Motor Complex in SMALL BOWEL
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Antibiotics, Insoluble fiber, Charcoal are a DISTRACTION. Your body through the MMC has the power to detoxify the small intestine ON ITS OWN. When your "stomach" is gurgling in between meals this is your small intestine doing its most comprehensive job pushing food, bacteria, etc, down to your colon.
Many of us DO NOT have a GOOD MMC. Most "motility" tricks do not encourage the MMC! Coffee, I strongly believe only activates the large intestine, mostly even just rectum. Many herbs are said to only activate the first stomach emptying portion of MMC. Fiber, by adding bulk, I fear enables the MMC to get away with doing a lazier job. Cascara, Magnesium high amounts, I fear have a crude dumping effect which evacuates your intestines without working in the electrical manner of MMC.
Fasting, despite controversy is perhaps the simplest way to encourage MMC and thus small intestine cleaning. I am not saying fasting for days at a time, rather something like waiting 50% longer between meals, or a 12 hour period, mostly during sleep. With this logic snacking is a very anti-mmc practice.
I AM ASKING HELP, what MMC/Prokinetic solutions have you experienced? Ginger/Artichoke blends are currently a gold standard OTC option although reviews are often mixed. It seems almost random which company's G/A mix people respond to. I believe medication Prucalapride is one of few RX MMC activators but I have heard few reviews.
I also fear no matter how good a supplement may be, if intestines are overloaded by (esp.) a high fat or meat diet, or just too much food in general, it will not be able to activate much. Since so many people trying to fix SIBO/IMO are doing these extreme diets, I think they ruin their chances of reacting positively to many pro kinetics--thus obscuring the reviews for which sups should actually work.
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@mikeyd said in MMC ACTIVATION DETOX - Migrating Motor Complex in SMALL BOWEL:
I AM ASKING HELP, what MMC/Prokinetic solutions have you experienced?
Hi,
I've used 0.5 mg prucaloride (resolor 1 mg, cut into 2 pieces with a sharp kitchen kife) as MMC activator. 2 months long. no need to go further. Taken 1-2 hours before bedtime,
case report:- histamine intolerance
- flatulence and gas. treated as if it was the beginning of a SIBO / SIFO.
- 1x/day stools (2x adviced in order to avoid stagnation of starches in the second part of the colon).
- homemade drink (water) with essential oils softgels. 4 kinds (With origan, mint, fennel, gingimber, etc.). every 4 hours.
NB: 4-5 hours interdigestive for MMC. - 1 caps DAO enzyme 1 000 000 units 2x/day. (to get rid of histamine)
I can give a link to my log if desired.
Hope it can help.
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@mikeyd
by this increasing ghrelin has effect, (or serotonin but many downsides) or motilin has effect https://www.nature.com/articles/nrgastro.2012.57
induce phase III which is the peak phase for movements (maybe the main reason why we get this activity between meals, ghrelin)was thinking maybe taking frequent amino acids https://pubmed.ncbi.nlm.nih.gov/14520028/ but here (through IV) reduced the MMC cycle duration https://gut.bmj.com/content/44/2/240 , maybe them going through digestive system matters, or using only essential if the second study didnt, or idea doesnt land
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC372329/
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833301/fixing hypothyroidism / getting good thyroid hormone function as everything slows down, reptile mode
(effect independent of ghrelin, didnt measure small intestine but did here https://pubmed.ncbi.nlm.nih.gov/2777044/)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113274/-
With hypothyroidism, time of phase I of interdigestive migrating contractions (IMC) was longer, time of phase II and phase III was significantly shortened, and both the continuous time of strong tetanic contraction at antrum and 10-h frequency of phase III counted from the first IMC after meal significantly decreased. Whereas, hyperthyroidism caused the opposite events to those with hypothyroidism.
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Furthermore, We found giant migrating contractions (GMC) occurred from the upper gastrointestinal tract when we administrated high dose of thyroid hormone.
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