D-mannose alleviates chronic periodontitis
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D-Mannose is known to help with UTIs humans. It may help with human periodontal inflammation as well.
D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils
Results
In vivo, D-mannose inhibited LPS-induced alveolar bone resorption in rats and suppressed the expression levels of IL-1β, IL-6, IL-17, TNF-α, G-CSF, GM-CSF, TET2, HK1, HK2, and PFKFB3, upregulated the expression level of IL-10, and inhibited the recruitment and activation of neutrophils in LPS-treated rat gingival tissues. In vitro, D-mannose was found to inhibit the activation of neutrophils stimulated by LPS, downregulate the expression of IL-1β, IL-6, IL-17, and TET2, and upregulate the expression of IL-10.
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